Expression of component desmosomal proteins in uterine endometrial carcinoma and their relation to cellular differentiation

Abstract

Reduction of desmoplakin I and II and desmoglein expression may play an important role in the invasiveness and metastatic activity of human endometrial carcinoma. They can therefore be used as differentiation markers for endometrial carcinoma.

Tight Junction Protein Claudin-1 Enhances the Invasive Activity of Oral Squamous Cell Carcinoma Cells by Promoting Cleavage of Laminin-5 γ2 Chain via Matrix Metalloproteinase (MMP)-2 and Membrane-Type MMP-1

“…The first step of invasion as well as metastasis is loss of cell-to-cell adhesion (6)(7)(8)(10)(11)(12). Cell-to-cell adhesion is strongly regulated by apparatuses, such as tight junctions, adherens junctions, desmosomes, and gap junctions (14)(15)(16)(17)(18)(19). Decreased expression of the component molecules of these adhesion apparatuses means a decrease of cell-to-cell adhesion, which would result in an increase of invasion activity of the cells.…”

“…Cell-to-cell adhesion apparatuses, such as tight junctions, adherens junctions, desmosomes, and gap junction, strongly regulate the invasion activity of cancer cells (14)(15)(16)(17)(18)(19). Tight junctions, one of the epithelial junctional complexes, are located at the most apical part of the complexes and consist of claudin and occludin.…”

Prognostic Significance of Desmoglein 2 and Desmoglein 3 in Esophageal Squamous Cell Carcinoma

“…It has been suggested that desmosomal components may contribute to the differentiation of human endometrial carcinoma (Nei et al, 1996). Besides, Kyrodimou et al (2013) and Gómez-Morales et al (2013) report that DSG3 is a marker for poorly differentiated OSCC and also for squamous differentiation in non-small-cell carcinomas.…”

Reduced membranous and ectopic cytoplasmic expression of DSC2 in esophageal squamous cell carcinoma: an independent prognostic factor

“…The differentiationdependent expression of cadherin proteins raises the possibility that, in addition to their adhesive function, they may have a direct or indirect role in regulating differentiation [25]. It has been suggested that desmosomal components may contribute to the differentiation status of human endometrial carcinoma [26]. Monica et al [27] reported that DSC3 was a marker of squamous differentiation in undifferentiated large-cell carcinoma of the lung.…”