Expression of corticosteroid binding globulin in the rat olfactory system

Dölz, W.; Eitner, Annett; Caldwell, Jack D.; Jirikowski, Gustav F.

doi:10.1016/j.acthis.2012.09.012

Cited by 12 publications

(5 citation statements)

References 49 publications

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“…For example, Berglund et al [ 82 ] concluded that the progesterone derivative 4,16-androstadien-3-one is a human pheromone. CBG and bound GCs or progestinlike pheromones are then internalized, as we have identifi ed CBG in both sensory and nonsensory VNO cells [ 70 ] . We have also identifi ed CBG processes in the accessory olfactory bulb (AOB) suggesting that CBG, once internalized, is transported by axons of VNO sensory neurons to the AOB for release.…”

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confidence: 75%

“…That CBG mediates this by a nongenomic action is supported by the fact that behavioral responses to pheromones are immediate. Unlike the VNO, mature olfactory sensory cells do not contain CBG while basal cells do express CBG [ 70 ] . Axonal projections within olfactory glomeruli, some of the periglomerular cells, and a fraction of the mitral cells of the main olfactory bulb contain CBG.…”

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confidence: 99%

“…A curiosity is that binding globulins also are found in the nose of mammals. Recently, Dölz et al [ 70 ] found CBG in both the vomeronasal organ (VNO) and the main olfactory system. The VNO is an important sensory organ for detection of pheromones and is found in rodents [ 71 , 72 ] , primates [ 73 ] , and humans [ 74 ] .…”

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confidence: 99%

“…Our current model of CBG action in the nose (see • ▶ Fig. 1 , Panel 3 ) is that CBG made in Bowman glands and in goblet cells is secreted into the nasal mucus [ 70 ] . The abundance of CBG in the mucus of the VNO then binds exogenous aerosol GCs, which may be alert or stress pheromones.…”

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confidence: 99%

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An Active Role for Steroid-binding Globulins: An Update

Caldwell

Jirikowski

2013

Horm Metab Res

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It has been 7 years (can it really be that long?) since we co-edited a volume (#38) of Hormone and Metabolic Research that focused on evidence that steroid-binding globulins play an active role in the actions of steroids. There has been considerable progress in identifying the location, the physiological actions, and of determining the role of binding globulins in the actions of steroids and identifying a membrane-associated receptor for a binding protein since then and this review will discuss this progress.

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confidence: 75%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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An Active Role for Steroid-binding Globulins: An Update

Caldwell

Jirikowski

2013

Horm Metab Res

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“…Glucocorticoid receptor mRNA and protein as well as corticosteroid binding globulin are expressed in the olfactory mucosa (Dölz et al, 2013;Robinson et al, 1998). Beneficial effects of corticoids on olfaction are found in the treatment of anosmia or hyposmia: oral and intranasally applied corticoids have been shown to improve olfaction, most likely through a reduction of nasal congestion and inflammation (Alobid et al, 2014).…”

Section: Which Biological Mechanisms Might Be Involved?mentioning

confidence: 99%

Stress lowers the detection threshold for foul-smelling 2-mercaptoethanol

Pacharra

Schäper

Kleinbeck

et al. 2015

Stress

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Previous studies have reported enhanced vigilance for threat-related information in response to acute stress. While it is known that acute stress modulates sensory systems in humans, its impact on olfaction and the olfactory detection of potential threats is less clear. Two psychophysical experiments examined, if acute stress lowers the detection threshold for foul-smelling 2-mercaptoethanol. Participants in Experiment 1 (N = 30) and Experiment 2 (N = 32) were randomly allocated to a control group or a stress group. Participants in the stress group underwent a purely psychosocial stressor (public mental arithmetic) in Experiment 1 and a stressor that combined a physically demanding task with social-evaluative threat in Experiment 2 (socially evaluated cold-pressor test). In both experiments, olfactory detection thresholds were repeatedly assessed by means of dynamic dilution olfactometry. Each threshold measurement consisted of three trials conducted using an ascending method of limits. Participants in the stress groups showed the expected changes in heart rate, salivary cortisol, and mood measures in response to stress. About 20 min after the stressor, participants in the stress groups could detect 2-mercaptoethanol at a lower concentration than participants in the corresponding control groups. Our results show that acute stress lowers the detection threshold for a malodor.

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