Sex hormone binding globulin in the rat olfactory system

Ploß, V.M.; Gebhart, V.M.; Dölz, W.; Jirikowski, Gustav F.

doi:10.1016/j.jchemneu.2014.03.003

Cited by 14 publications

(6 citation statements)

References 38 publications

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“…Recently, a research on the mechanism of olfactory steroid production in rats found that sex hormone-binding globulin contributed to the rapid effects of olfactory steroids on limbic functions. [5] These observations led us to question whether sex hormone-binding globulin also plays a role in endometrial proliferation and whether hypogammaglobulinemia reduces the binding of sex hormones with sex hormone-binding globulin. Furthermore, estrogen and progesterone exert their function by binding to specific receptors, which are present within most cell types and, specifically, on several types of immune cells.…”

Section: Discussionmentioning

confidence: 99%

Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency

Zhou

Chen

Peng

et al. 2017

Chinese Medical Journal

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Section: Discussionmentioning

confidence: 99%

Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency

Zhou

Chen

Peng

et al. 2017

Chinese Medical Journal

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“…The gonadal steroids have numerous effects in brain and the discovery that the steroid-binding protein SHBG is taken up into neurons and brain cells may demand a change in thinking about how steroids are delivered to brain cells to affect neurophysiology [28]. Results in a recent study of SHBG in the rat olfactory system by immunocytochemistry and RT-PCR suggest that SHBG may be of functional importance for rapid effects of olfactory steroids on limbic functions including the control of reproductive behaviors through pheromones [29].…”

Section: Discussionmentioning

confidence: 99%

Age-Dependent Sex Hormone-Binding Globulin Expression in Male Rat

Fan

et al. 2015

Ultrastructural Pathology

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Sex hormone binding globulin (SHBG) is known as a carrier protein, classically thought to be mainly synthesized in the liver and then secreted into the circulating system, where it binds to sex steroids with a high affinity and modulates the bioavailability of these hormones. In humans, the organs other than the liver known to produce SHBG include the brain, uterus, testis, prostate, breast and ovary, and the locally expressed SHBG is considered to play an important role in various physiological and pathological processes. A few studies of SHBG in rats were reported, but systemic SHBG studies in consideration of different organs and aging are currently missing. So we examined the SHBG expression in the brain, liver, prostate, and serum in 40 Sprague-Dawley male rats in four different groups (newborn, 2, 6, and 12 months old, respectively) with 10 in each group by immunohistochemistry, immunofluorescience microscopy, qRT-PCR, ELISA, western blotting, and laser confocal microscopy. We discovered that SHBG was increasingly expressed in all the three tissues along with age, and the SHBG protein expression was observed in the cytoplasm and membrane of neurons, hepatocyte, and prostate epithelial cells. The ELISA assay of the sera also supported an increasing SHBG level along with age. It is concluded that the locally synthesized SHBG in the liver, brain, and prostate and the circulating SHBG of male SD rats are positively associated with age, further indicating a potential role of SHBG in aging.

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“…More work needs to be completed to determine the functional relevance of this signalling, as well as the source, potentially local, of vasopressin in this region. With the recent description of steroid-binding globulins within the main olfactory epithelium, it would be informative to examine co-localization and steroid-sensitivity of V1aR in this area, considering the dependence of some other vasopressin-signalling regions on gonadal steroids (Caldwell et al 2017; Ploss et al 2014). Unlike in the MOE, neither vasopressin nor its receptors have been identified in the VNO.…”

Section: Vasopressin and Odour Processingmentioning

confidence: 99%

The role of vasopressin in olfactory and visual processing

Wacker

Ludwig

2018

Cell Tissue Res

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Neural vasopressin is a potent modulator of behaviour in vertebrates. It acts at both sensory processing regions and within larger regulatory networks to mediate changes in social recognition, affiliation, aggression, communication and other social behaviours. There are multiple populations of vasopressin neurons within the brain, including groups in olfactory and visual processing regions. Some of these vasopressin neurons, such as those in the main and accessory olfactory bulbs, anterior olfactory nucleus, piriform cortex and retina, were recently identified using an enhanced green fluorescent protein-vasopressin (eGFP-VP) transgenic rat. Based on the interconnectivity of vasopressin-producing and sensitive brain areas and in consideration of autocrine, paracrine and neurohormone-like actions associated with somato-dendritic release, we discuss how these different neuronal populations may interact to impact behaviour.

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Sex hormone binding globulin in the rat olfactory system

Cited by 14 publications

References 38 publications

Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency

Secondary Amenorrhea in a Patient with Common Variable Immunodeficiency

Age-Dependent Sex Hormone-Binding Globulin Expression in Male Rat

The role of vasopressin in olfactory and visual processing

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