Expression of COX-2 and HER-2 in colorectal cancer and their correlation

Abstract

COX-2 and HER-2 are important markers for invasion and metastasis of colorectal cancer, and they act together to regulate the invasion and metastasis of colorectal cancer.

Immunohistochemical Study of HER2/neu Expression in Colorectal Cancer and its Relation to other Clinicopathological Criteria and Prognostic Factors

“…Li et al (2014) by their meta-analysis, stated that HER2/neu overexpression probably has little impact on CRC survival (6). Recently another meta-analysis revealed that no correlation existed between HER2/neu expression and clinicopathological features including tumor location, grade of differentiation, TNM stages and lymph node metastasis (28). In our study, there was also no significant association between HER2/neu over expression and clinicopathological parameters (age, gender, size, location of tumor, tumor grade and stage).…”

“…So it is unclear whether HER2/neu is a potential therapeutic target or/and a prognostic marker in patients with CRC or not (23,(28)(29)(30).…”

Cyclooxygenase-2 Expression in Colorectal Cancer in North India- A Pilot Study

“…Largest number of colorectal patients are in age range of 21-40 years ( Figure: 1). In our study, 80% cases of colorectal carcinomas showed varying degree of cytoplasmic COX-2 positivity which corresponded very much to the findings of Wu et al in 2015 [6] who had similar observation of overexpression of COX-2 in 77.97% cases of colonic adenocarcinomas. In our study, 71.42% cases of well-differentiated adenocarcinoma of colorectum showed positivity for COX-2 ( Figure: 2 & 3), whereas all cases of moderately ( Figure: 4) and poorly differentiated adenocarcinoma of colorectum showed positivity for COX-2 (Table: 1).…”

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

“…A COX-2 increased expression has been seen in many tumors, including CRC [22]. In detail, an enhanced expression of COX-2 was detected in 77% of cases of CRC as compared with the normal surrounding mucosa [23].…”

“…Another study by Watson et al about curcumin cytotoxicity on HCT-116 and HT29 cell lines revealed that a sequential time and dose dependent inhibition of cell proliferation was observed when p53 was upregulated [21].As reported above, one of the main mechanisms through which curcumin blocks cell growth is the induction of apoptosis. This process in the CRC cells involves multiple molecular targets including enzymes (cyclooxygenase-2 (COX 2)), transcription factors (NF-kB and beta-catenin), Bcl-2 family members (Bcl-2, Bax, and Bcl-xL), death receptors (death receptor 5 (DR5) and Fas), protease enzymes (caspase 3 and caspase 8), and ROS.A COX-2 increased expression has been seen in many tumors, including CRC [22]. In detail, an enhanced expression of COX-2 was detected in 77% of cases of CRC as compared with the normal surrounding mucosa [23].…”