Expression of cytochrome P450 2C and 3A in female rat liver after long-term administration of gonadoliberin analogs

Skowronek, Rafał; Czekaj, Piotr; Suszka-Świtek, Aleksandra; Czech, Ewa; Wiaderkiewicz, Anna; Plewka, Danuta; Bryzek, Aleksandra

doi:10.13075/ijomeh.1896.00528

Int J Occup Med Environ Health

2015

DOI: 10.13075/ijomeh.1896.00528

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Expression of cytochrome P450 2C and 3A in female rat liver after long-term administration of gonadoliberin analogs

Rafał Skowronek¹,

Piotr Czekaj²,

Aleksandra Suszka-Świtek³

et al.

Abstract: In adult female rats, HNF4α/HNF6 and STAT5b seem to be crucial for the regulation of GnRH antagonist/GH- and GnRH agonist/GH-dependent pattern of CYP450 expression, respectively.

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Cited by 5 publications

References 33 publications

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Functions of pregnane X receptor in self-detoxification

Zhou

Huang

et al. 2017

Amino Acids

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Pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, is a crucial regulator of nutrient metabolism and metabolic detoxification such as metabolic syndrome, xenobiotic metabolism, inflammatory responses, glucose, cholesterol and lipid metabolism, and endocrine homeostasis. Notably, much experimental and clinical evidence show that PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. In this review we summarize recent advances on remarkable metabolic and regulatory versatility of PXR, and we emphasizes its role and potential implication as an effective modulator of self-detoxification in animals and humans.

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Functions of pregnane X receptor in self-detoxification

Zhou

Huang

et al. 2017

Amino Acids

View full text Add to dashboard Cite

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Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen

Wen

Zhuang

Song

et al. 2018

Biomedicine & Pharmacotherapy

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Worldwide, aspirin and ibuprofen are the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs). Some adverse reactions, including gastrointestinal reactions, have been concerned extensively. Nevertheless, the mechanism of liver injury remains unclear. In the present study, we focused on the metabolism of liver cytochrome P450 (CYP450) and ultrastructural morphology of liver cells. A total of thirty rats were divided into three groups of 10. Rats in the aspirin and ibuprofen groups were given enteric-coated aspirin (15 mg/kg) and ibuprofen (15 mg/kg), respectively by gavage for four weeks. The body weights were recorded every two days. Liver function and metabolic capacity of CYP450 were studied on days 14 and 28. We then conducted ultrastructural examinations. Body weights in the Ibuprofen group were lower than those of the Control group, and ALT and AST levels were significantly higher (P < 0.05). There were no significant differences in terms of body weight, ALT or AST between the Aspirin and Control groups. The metabolic capacity of CYP450 was evaluated using five probe drugs, phenacetin, tolbutamide, metoprolol, midazolam, and bupropion. We found that ibuprofen and aspirin induced metabolism of the probe drugs. Moreover, according to the pharmacokinetic data, the Control, Aspirin and Ibuprofen groups could be discriminated accurately. Ultrastructural examination showed that the number of mitochondria was increased in both the Ibuprofen and Aspirin groups. Long-term administration of enteric-coated aspirin and ibuprofen induced the metabolic activity of the CYP450 enzyme. Aspirin had better tolerability than did ibuprofen, as reflected by pharmacokinetic data of probe drug metabolism.

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Changes in mRNA and protein levels of gonadotropin releasing hormone and receptor in ovine thymus, lymph node, spleen, and liver during early pregnancy

Cao

Gao

et al. 2021

Domestic Animal Endocrinology

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Expression of cytochrome P450 2C and 3A in female rat liver after long-term administration of gonadoliberin analogs

Abstract: In adult female rats, HNF4α/HNF6 and STAT5b seem to be crucial for the regulation of GnRH antagonist/GH- and GnRH agonist/GH-dependent pattern of CYP450 expression, respectively.

Cited by 5 publications

References 33 publications

Functions of pregnane X receptor in self-detoxification

Functions of pregnane X receptor in self-detoxification

Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen

Changes in mRNA and protein levels of gonadotropin releasing hormone and receptor in ovine thymus, lymph node, spleen, and liver during early pregnancy

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