Expression of cytokeratins, adhesion and activation molecules in oral ulcers of Behçet's disease

Köse, Osman; Stewart, James E.; Waseem, Ahmad; Lalli, Anand; Fortune, Farida

doi:10.1111/j.1365-2230.2007.02558.x

Cited by 15 publications

(14 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, these compounds down-regulated TNFα and adhesion molecules in Behcet's disease mice and ameliorated the symptoms. TNFα and adhesion molecules have been shown to be up-regulated in Behcet's disease patients (Sayinalp et al, 1996;Kose et al, 2008). In addition, downregulation of TNFα using anti-TNFα antibody (Infliximab) was found to suppress various Behcet's disease symptoms including sight-threatening panuveitis (Sfikakis et al, 2001) and intestinal ulcers (Ju et al, 2007) in patients and mice (Choi et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

Choi

Kim

Lee

et al. 2011

European Journal of Pharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

Choi

Kim

Lee

et al. 2011

European Journal of Pharmacology

View full text Add to dashboard Cite

“…2. In BD, the keratinocytes (KERs) of mucocutaneous tissues and endothelial cells (ENDs) 5,21,33,37 are involved during the first contact with the triggering factors and they contribute to the inflammation by releasing pro-inflammatory cytokines. With the help of secreted molecules, KERs and ENDs attract immune cells such as neutrophils, 5,23,35,38,39 monocytes 40,41 and NK cells 16,[42][43][44] to accumulate at the site of insult to induce an inflammatory reaction, as represented by squares 3-6 in Fig.…”

Section: The Cells In Action In Bd and Disease Progressionmentioning

confidence: 99%

Mathematical Modeling of Behçet's Disease: A Dynamical Systems Approach

et al. 2015

View full text Add to dashboard Cite

Behçet's Disease (BD) is a multi-systemic, auto-inflammatory disorder that is characterized by recurrent episodes of inflammatory manifestations affecting skin, mucosa, eyes, blood vessels, joints and several other organs. BD is classified as a multifactorial disease with an important contribution of genetics. Genetic studies suggest that there is a strong association of BD with a Class I major histocompatibility complex antigen, named HLA-B*51, along with several other weaker associations with genes encoding proteins involved in inflammation. However, pathogenic mechanisms associated with these genetic variations and their interactions with the environment have not been elucidated yet. In this paper, we present a mathematical model for BD based on a dynamical systems perspective that captures especially the relapsing nature of the disease. We propose a disease progression mechanism and construct a model, in the form of coupled ordinary differential equations (ODEs), which reveals the occurrence pattern of the disease in the population. According to our model, the disease has three distinct modes describing different phenotypes of people carrying HLA-B*51 tissue antigen, namely, the Healthy Carrier, the Potential Patient and the Active Patient. We herein present an exemplary mathematical model for BD, for the first time in the literature, that concisely captures the actions of many cell types together with genetic and environmental effects. The proposed model provides insight into this complex inflammatory disease which may lead to identification of new tools for its treatment and prevention.

show abstract

“…In our study, expression of the γδ +T cells in oral ulcers from BD patients were studied. It was found heterogeneous expression of the γδ +T cells throughout the epithelium and in connective tissue around the ulcer base [9]. …”

Section: Immunopathogenesis Of Behçet's Diseasementioning

confidence: 99%

Development of Immunopathogenesis Strategies to Treat Behçet’s Disease

Köse

2012

Pathology Research International

View full text Add to dashboard Cite

Behçet disease is a chronic relapsing vasculitis with unclear etiology and immunopathogenesis. Antigenic stimuli, antigen presenting cells, T cells, monocyte, and neutrophil and endothelial cells are major parts of the pathology of the disease. Understanding of the new pathogenic mechanisms based on molecular structure of the disease helps us in improving the novel therapeutic modalities. These drugs target specific and nonspecific inhibition of the immun system. These therapies include biologic agents, new topical and systemic immunosuppressants, tolerizing agents, and immunoablation. Novel treatment will be promising to treat the especially recalcitrant cases to conventional therapy. In this paper, new aspect of the immunopathogenesis of Behçet's diseases and novel treatment modalities will be discussed.

show abstract

Expression of cytokeratins, adhesion and activation molecules in oral ulcers of Behçet's disease

Abstract: Our data demonstrates changes in cell-cell and cell-extracellular matrix interactions that affect cell homeostasis and may participate in the formation of oral ulcers in BD.

Cited by 15 publications

References 24 publications

Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

Mathematical Modeling of Behçet's Disease: A Dynamical Systems Approach

Development of Immunopathogenesis Strategies to Treat Behçet’s Disease

Contact Info

Product

Resources

About