Expression of cytokines and chemokine receptors in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis

Abstract

We have provided further evidence that TNF-alpha is strongly expressed in SJS/TEN lesions and therefore it may be involved in the epidermal necrosis featured in such diseases. IFN-gamma may play an important role both in EM and SJS/TEN. IL-2, IL-5 and IL-13 may contribute to the cutaneous immunoinflammation in these diseases. Chemokine receptors may be involved strongly in the recruitment of inflammatory cells in lesional skin. In our cases we found a sharp polarization towards a Th1 pattern in EM, while the SJS/TEN lesions showed a mixed Th1/Th2 pattern.

Levels of Tumor Necrosis Factor-Alpha, Interleukin-6, and Interferon- Gamma during the Active Phases of Bechet’s Disease, Pustular Psoriasis, Palmoplantar Pustulosis, and Stevens-Johnson Syndrome: A Pilot Study

“…Interestingly, the PP patient exhibited actual values that were similar to the expected value. This result is consistent with the close relationship between psoriasis and Th17 lymphocytes [5]. Furthermore, in psoriasis, there is the paper that Values at the start and after improvement are shown for each cytokine measured clarified the relation between IL-6 and metabolic syndrome [6].…”

Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus

“…Tumor necrosis factor-alpha (TNF-α) has been shown to be strongly expressed in SJS lesions by an Italian group [11] . Authors suggest that IFN-gamma may play an important role in SJS.…”

Pathway analysis for identification of potential biomarkers in severe cutaneous drug hypersensitivity reactions

“…Previously published studies have shown that several cytokines might play an important role in the apoptosis or cytokine flooded inflammation [8,22,23]. Among these recently discovered cytokines are the interleukin (IL), IL-6, IL-8 and monocyte chemo-attractant protein-1 (MCP-1) and all were reported to be unregulated in SJS and TEN [8].…”