Expression of DCP1a in gastric cancer and its biological function and mechanism in chemotherapy resistance in gastric cancer cells

Ruan, Tuo; Ya-zhi, Zhang; Liu, Weizhen; Li, Yuan; Wang, Dianshi; Du, Zhouyuan; Tao, Kaixiong; Wu, Chen

doi:10.1016/j.dld.2020.06.031

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…Currently, only a few studies have explored the relationship between DCP1A and malignancy. A study by Ruan et al [ 23 ] reported that high DCP1A expression level is correlated with occurrence and development of gastric cancer and prognosis of gastric cancer. Resistance of gastric cancer cells to chemotherapy can be abrogated by downregulation of DCP1A expression.…”

Section: Discussionmentioning

confidence: 99%

DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma

Zhang

Bai

et al. 2021

Aging

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Long non-coding RNAs (lncRNAs) are associated with occurrence and development of tumors. Enhancer RNA (eRNA) is a special type of lncRNAs produced from transcription of enhancer elements. The function of eRNAs in tumors have elicited significant attention recently. However, the clinical significance and role of eRNAs in hepatocellular carcinoma (HCC) has not been fully explored. The current study sought to explore the expression level and prognostic value of key eRNAs in HCC. Bioinformatics analyses were used to explore expression levels of key prognostic eRNAs in HCC and their correlation with target genes. A total of 1580 enhancer RNAs (eRNAs) and 1791 target genes were initially retrieved from TCGA-LIHC gene expression database. Further analysis through survival and correlation analysis led to identification of 12 eRNAs and 13 target genes. The findings showed that DCP1A was the most prognosis-related eRNA. This eRNA showed the highest correlation with the target gene, PRKCD. Analysis showed that poor overall survival (OS) in HCC patients was correlated with high expression level of DCP1A (eRNA) and PRKCD (target gene). The up-regulation of DCP1A was associated with advanced tumor stage, larger tumor size and higher histological grade. The results of pan-cancer analysis showed that the expression of DCP1A was differentially expressed in 13 other types of tumor tissues and their corresponding normal tissues. This eRNA was highly expressed in digestive system tumors. Functional analysis showed that high expression level of DCP1A was implicated in multiple tumor-related signaling pathways. The findings of the current study indicated DCP1A is a novel biomarker that can be used as a potential therapeutic target for HCC patients.

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Section: Discussionmentioning

confidence: 99%

DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma

Zhang

Bai

et al. 2021

Aging

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“…The Venn diagram displayed 3 common targets, among which merely DCP1A exhibited an obvious decrease under miR - 3681 - 5p overexpression. Ruan et al has demonstrated that heightened DCP1A is associated with poor prognosis, and its downregulation decreases proliferation, migration, and chemotherapy resistance ( 24 ). In gastric cancer, DCP1A has been affirmed to be controlled by the LINC00339 / miR - 377 - 3p pathway and to accelerate tumor progression ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

“…Among these genes, mRNA-decapping enzyme 1A ( DCP1A ) is in close association with cancer progression. DCP1A is highly expressed and related to poor prognosis, downregulation of which can reduce proliferation, migration, and chemotherapeutic resistance ( 24 ). Also, overexpression of DCP1A decreases the survival rate of colorectal carcinoma patients ( 25 ).…”

Section: Introductionmentioning

confidence: 99%

LncRNA HOXD-AS2 regulates miR-3681-5p/DCP1A axis to promote the progression of non-small cell lung cancer

Zhang¹,

Ma²

2023

J Thorac Dis

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Background: Non-small cell lung cancer (NSCLC) is the most common malignancy in lung cancer, with a low survival rate and unfavorable prognosis. Dysregulated long non-coding RNAs (lncRNAs) play vital functions in tumor progression. This study intended to probe the expression pattern and function of HOXD-AS2 in NSCLC.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to analyze the expression of HOXD-AS2, miR-3681-5p, CCR1, mRNA-decapping enzyme 1A (DCP1A), and PPP3R1.Cell viability, migration, and invasion were separately examined via 3-(4,5-dimethylthiazolyl-2)-2,5diphenyltetrazolium bromide (MTT) and transwell experiments. Luciferase reporter assay was conducted to evaluate the binding of miR-3681-5p with HOXD-AS2 or DCP1A. Protein expression of DCP1A was assessed via Western blot. NSCLC animal models were constructed through injection of H1975 cells transfected with lentivirus (LV)-sh-HOXD-AS2 into nude mice, followed by hematoxylin and eosin (HE) staining and immunohistochemistry (IHC) analysis.Results: In this study, HOXD-AS2 was upregulated in NSCLC tissues and cells, and high HOXD-AS2 predicted short overall survival (OS). Downregulation of HOXD-AS2 could impair the proliferation, migration, and invasion abilities of H1975 and A549 cells. MiR-3681-5p was shown to bind with HOXD-AS2 and be lowly expressed in NSCLC. Suppression of miR-3681-5p could abolish the inhibitory effect of HOXD-AS2 silencing on proliferation, migration, and invasion. DCP1A was screened as the target of miR-3681-5p and its overexpression could rescue miR-3681-5p upregulation-repressed proliferation, migration, and invasion activities. Moreover, animal experiments affirmed that HOXD-AS2 promoted tumor growth in vivo.Conclusions: HOXD-AS2 modulates the miR-3681-5p/DCP1A axis to boost the progression of NSCLC, which founds the basis of HOXD-AS2 as a new diagnostic biomarker and molecular target for NSCLC therapy.

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“…The two genes that define the significant GO terms are Decapping MRNA 1A (DCP1A) and C-Reactive Protein (CRP). We found two intronic variants with allele frequency <0.45 and 2 upstream variants within the TFBS of DCP1A, which is a biomarker used for gastric [ 85 ], colorectal [ 86 ], and hepatocellular cancer progression [ 87 ]. Six variants were found downstream of the CRP gene, which is an inflammatory biomarker closely associated with prognosis in lung and gastric cancers, as well as those involving PD1 [ 88 , 89 , 90 ].…”

Section: Resultsmentioning

confidence: 99%

“…MHC regions have notably high levels of diversity that can lead to difficulties with alignment, particularly between species [ 85 ]. The average depth for these regions was 14.71 (HLA-DRB1: 12.53, DLA-DQA1: 15.54, DLA_DRA and DLA-DQB1: 16.07), with quality (GQ) ranging from 38.08 to 50.58 (HLA-DRB1: 50.58, DLA-DQA1: 45.8, DLA_DRA and DLA-DQB1: 38.08).…”

Section: Resultsmentioning

confidence: 99%

Genomic Assessment of Cancer Susceptibility in the Threatened Catalina Island Fox (Urocyon littoralis catalinae)

Hendricks

King

Duncan

et al. 2022

Genes

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Small effective population sizes raise the probability of extinction by increasing the frequency of potentially deleterious alleles and reducing fitness. However, the extent to which cancers play a role in the fitness reduction of genetically depauperate wildlife populations is unknown. Santa Catalina island foxes (Urocyon littoralis catalinae) sampled in 2007–2008 have a high prevalence of ceruminous gland tumors, which was not detected in the population prior to a recent bottleneck caused by a canine distemper epidemic. The disease appears to be associated with inflammation from chronic ear mite (Otodectes) infections and secondary elevated levels of Staphyloccus pseudointermedius bacterial infections. However, no other environmental factors to date have been found to be associated with elevated cancer risk in this population. Here, we used whole genome sequencing of the case and control individuals from two islands to identify candidate loci associated with cancer based on genetic divergence, nucleotide diversity, allele frequency spectrum, and runs of homozygosity. We identified several candidate loci based on genomic signatures and putative gene functions, suggesting that cancer susceptibility in this population may be polygenic. Due to the efforts of a recovery program and weak fitness effects of late-onset disease, the population size has increased, which may allow selection to be more effective in removing these presumably slightly deleterious alleles. Long-term monitoring of the disease alleles, as well as overall genetic diversity, will provide crucial information for the long-term persistence of this threatened population.

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Expression of DCP1a in gastric cancer and its biological function and mechanism in chemotherapy resistance in gastric cancer cells

Cited by 6 publications

References 48 publications

DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma

DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma

LncRNA HOXD-AS2 regulates miR-3681-5p/DCP1A axis to promote the progression of non-small cell lung cancer

Genomic Assessment of Cancer Susceptibility in the Threatened Catalina Island Fox (Urocyon littoralis catalinae)

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