Expression of E-Cadherin in Prostatic Carcinoma: Prognostic Significance

Bengallol, Taghrid; El-Faitori, Omran; S, Sassi; Gehani, Fatma Ben Khaial Khaled El; Buhmeida, Abdelbaset; Elzagheid, Adam

doi:10.15406/jcpcr.2016.04.00119

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…The following cut-off score was used for calculation: HER2/neu overexpression assessment was categorised as 0 (negative), 1 (weakly positive), 2 (moderately positive), 3 (strongly positive) [5]. E-cadherin expression was categorised as 0 (no/weak expression), 1 (moderate expression), 2 (intense staining) [10].…”

Section: Study Proceduresmentioning

confidence: 99%

“…Decreased E-cadherin expression has been observed in prostatic carcinoma, leading to the hypothesis that it may be a predictor of prostate cancer progression. However, there are controversial findings regarding E-cadherin and its expression in different studies [9,10]. Therefore, the present study aimed to evaluate the immune expression status of HER2/neu and E-cadherin and compare it with clinicopathological parameters in prostate adenocarcinoma.…”

Section: Introductionmentioning

confidence: 97%

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Immunohistochemical Expression Status of HER2/neu and E-cadherin in Prostate Adenocarcinoma: A Cross-sectional Study

Reddy,

Javalgi,

Parmesh

2024

NJLM

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Introduction: Prostate cancer is a common tumour, accounting for 92% of malignancies in the male genital tract. Due to the high recurrence rate, it is important to identify prognostic markers in prostate cancer. Human Epidermal Growth Factor Receptor 2 (HER2) and Epithelial cadherin (E-cadherin) are speculated to be associated with carcinogenesis, but the literature has provided controversial results. Aim: To investigate the expression of HER2/neu and E-cadherin in prostatic adenocarcinoma and its correlation with clinicopathological parameters. Materials and Methods: A retrospective cross-sectional study was conducted at the Department of Pathology, SDM University, Dharwad, Karnataka, India. The study duration was one year and five months, from October 2020 to March 2022. A total of 45 cases diagnosed as prostatic adenocarcinoma between October 2016 and September 2019 were included. Clinicopathological parameters such as age, Prostate- Specific Antigen (PSA) levels, metastasis, perineural invasion, Gleason score, Gleason grade, and two-year survival were retrieved from hospital records and through telephone interviews. Immunohistochemistry (IHC) staining for HER2 and E-cadherin was performed and assessed by pathologists. Statistical analysis was conducted using Statistical Package for Social Sciences (SPSS) version 20.0, and the Chi-square test was applied. Results: The mean age of the study participants was 69.6 years, ranging from 52 to 95 years. The rates of HER2/neu overexpression/positivity and reduced E-cadherin expression were 25 (55.5%) and 14 (31.1%), respectively. No statistically significant associations were found between HER2 and E-cadherin expression and age, PSA levels, perineural invasion, Gleason score, Gleason grade, and two-year survival (p>0.05). However, a statistically significant association was observed between HER2 expression and distant metastasis (p-value=0.006), whereas no significant association was found with E-cadherin (p-value=0.81). Conclusion: The study demonstrated a significant association between HER2/neu overexpression and tumour metastasis, suggesting that HER2/neu could serve as a prognostic parameter to assist surgeons. In contrast, E-cadherin showed no association with clinicopathological parameters, raising questions about its involvement in the progression of prostatic adenocarcinoma.

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Section: Study Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Immunohistochemical Expression Status of HER2/neu and E-cadherin in Prostate Adenocarcinoma: A Cross-sectional Study

Reddy,

Javalgi,

Parmesh

2024

NJLM

View full text Add to dashboard Cite

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“…13,17 E-cadherin is important for development and maintenance of epithelium and is one of the most essential molecules in cell-to-cell adhesion. 18 The deficit of E-cadherin-mediated cell adhesion associates with the loss of the epithelial morphology and results in invasion of tumor cells. 19 It has been studied in many malignant tumors as a prognostic marker and a study has reported its usefulness in the histopathological clear margins of OSCC.…”

Section: Introductionmentioning

confidence: 99%

The prognostic role of immunohistochemical markers in surgical margins of Indian patients with oral squamous cell carcinoma- a retrospective study protocol

Ranka¹,

Chaudhary²,

Sharma³

et al. 2021

Int J Clin Trials

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Background: Positive surgical margins in oral squamous cell carcinoma (OSCC) is an important predictor of recurrence. Unfortunately, recurrence is found in cases with negative surgical margins as well and hence molecular markers are being investigated to identify the tumor cells in negative surgical margins to improve the survival of patients. The study aimed to ascertain the prognostic role of p53, eIF4E and E-cadherin in negative surgical margins and association of their expression with clinical parameters, recurrence, and survival.Methods: India based retrospective cohort study of patients who were surgically treated for OSCC between 2011 and 2014. Thirty patients with negative surgical margins were assessed for this study. Sixty-four negative surgical margins were evaluated using immunohistochemistry with monoclonal mouse p53, monoclonal rabbit eIF4E and monoclonal mouse E-cadherin antibodies.Results: Fisher’s exact test, Fishers Freeman Halton exact test and contingency tables were used to assess the association between recurrence rate and clinicopathologic parameters also any association with the expression of p53, eIF4E and E-cadherin in the surgical margins and each patients’ clinical characteristics. ANOVA (analysis of variance) was used to assess the role of clinicopathologic parameters in survival of the patients. The sensitivity and specificity of each antibody along with positive and negative predictive values were calculated. Kaplan Meier was used for analysis of recurrence and five-year survival. P<0.05 was used to denote a statistically significant difference.Conclusion: This study could help in identification of patients with minimal residual cancer in the surgical margins and might help in better therapeutic management to improve survival of OSCC patients.

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Expression of E-Cadherin in Prostatic Carcinoma: Prognostic Significance

Cited by 2 publications

References 28 publications

Immunohistochemical Expression Status of HER2/neu and E-cadherin in Prostate Adenocarcinoma: A Cross-sectional Study

Immunohistochemical Expression Status of HER2/neu and E-cadherin in Prostate Adenocarcinoma: A Cross-sectional Study

The prognostic role of immunohistochemical markers in surgical margins of Indian patients with oral squamous cell carcinoma- a retrospective study protocol

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