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Myxoid variant of chondrosarcoma is an uncommon potentially lethal malignant tumor which is even rare in pediatric age group. In the present paper, we report one such case of intermediate grade myxoid chondrosarcoma of left side of maxilla in a 12-year-old girl. The present case had a firm, painless, and lobulated growth in premolar-molar region which was associated with bicortical expansion. Maxillofacial imaging showed ill-defined radiolucency with displaced maxillary molars. Osteolytic changes were evident with the alveolus and walls of maxillary sinus. Owing to the age of the patient, surgical excision was selected as the modality of management followed by postoperative radiotherapy. This report encompasses the entire gamut of clinicopathological, radiological, and treatment modalities employed for chondrosarcoma.

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Objective(s):The aim and objective of this study was to systematically evaluate the prognostic role of immunohistochemical markers in surgical margins of patients with head and neck squamous cell carcinoma (HNSCC).Materials and Methods: MEDLINE/PubMed, Scopus and Cochrane library were searched for relative studies until December 2018. Retrospective and prospective original research studies published in English language assessing the prognostic value of immunohistochemical markers and disease-free survival in HNSCC and oral squamous cell carcinoma (OSCC) were included.Results: A total of eight studies were included comprising of 269 cases. The studies included here used eukaryotic initiation transcription factor 4E (eIF4E) in HNSCC patients; Matrix metalloproteinase (MMP), MMP2, MMP3, MMP9, Dentin Sialo-Phosphoprotein (DSPP), Bone Sialoprotein (BSP), Osteopontin (OPN), Beta-2-adrenergic receptors and E-cadherin in OSCC patients and p53 in HNSCC and OSCC. Among all the markers studied MMP9 had the highest accuracy at 80% followed by p53 (75%), DSPP (70%) and OPN (70%) while eIF4E (33.3%) had least accuracy. A study suggested that E-cadherin is the preferred marker over MMP9. Almost all the studies used Fisher's exact and Fisher-Freeman-Halton significance test. Only one study was at low risk of bias, three studies were at moderate risk of bias, three studies had serious risk of bias and in one study bias could not be calculated due to inadequate information. Conclusions:The study shows that immunohistochemical markers can significantly contribute to the field of head and neck carcinomas. Future efforts should concentrate on improving the antibody selection and its performance in the patients.

BackgroundInflammation is present in denture stomatitis. Denture stomatitis's etiology is complex, but there is evidence that it is brought on by Candida albicans growing in biofilms on its surface. ObjectiveThis study aimed to examine and assess the effectiveness of several herbal products, such as tea tree oil and neem extracts, on Candida albicans adhesion to denture soft liners. MethodEach wall of the tissue culture plate was filled with 30 acrylic blocks lined with soft liners, followed by the addition of 0.1 ml of the standardized Candida albicans suspension, which was then left to incubate for 48 hours. Each specimen was placed in a disinfectant solution for 10 minutes. A colony was counted after 0.1ml of the solution was plated on a sabouraud dextrose agar (SDA) plate and cultured for 72 hours. Data were compared using a one-way analysis of variance (ANOVA) test. ResultsThe mean colony forming units (CFU) per ml for combined tea tree oil and neem extract was least (0.40), followed by tea tree oil (2.30), followed by neem extract (30.33). The treated blocks were effective in reducing the growth of Candida albicans. ConclusionCombining tea tree oil and neem extract significantly reduced the growth of Candida albicans, suggesting a new form of intraoral effective antifungal treatment.