Expression of epidermal growth factor receptor in the inverted papilloma and squamous cell carcinoma of nasal cavity

Abstract

The present study was undertaken to compare positive rate of immunostaining (PR) and positive intensity of immunostaining (PI) of epidermal growth factor receptor (EGFR) in inverted papilloma (IP), synchronous carcinoma with IP and metachronous carcinoma with IP of the nasal cavity. Ten subjects with nasal polyps, ten subjects with inverted papilloma (IP), five subjects with synchronous carcinoma with IP and ten subjects with metachronous carcinoma with IP were enrolled with a control group of ten subjects of inferior turbinate. Each specimen was divided into two portions: one for RNA isolation and the other for detection of EGFR protein. Positive rate of immunostaining, positive intensity of immunostaining for EGFR protein and EGFR mRNA were significantly up-regulated in the IP, synchronous carcinoma with IP and metachronous carcinoma with IP when comparing polyp and normal mucosa. A role for EGFR in the malignant transformation from IP to SCC of the nasal cavity is suggested.

Common Head and Neck Cases in Our Consultation Referrals: Diagnostic Dilemmas in Inverted Papilloma

“…Increased expression of EGFR and TGFa has been observed on immunostaining in benign inverted papilloma and those associated with dysplasia and carcinoma in situ [10]. HPV infection has been shown to elevate EGFR levels by post translational mechanisms in keratinocytes and laryngeal papilloma cells [9].…”

Sinonasal inverted papilloma: narrative review

“…This suggests a role for epithelial growth factor receptor in the malignant transformation of inverted papilloma to SCC of the nasal cavity. 81 Follow up Recurrent inverted papilloma and metachronous carcinoma can develop after a prolonged period of time. Long-term follow up is recommended to detect recurrence, as disease can become extensive before it becomes symptomatic.…”

Skull Base Inverted Papilloma: A Comprehensive Review

“…Increased epithelial cell proliferation, but not apoptosis and apoptosis inhibition, seems to be involved in the development of IP [170, 171]. An increased epidermal growth factor receptor (EGFR) and Tumor growth factor- (TGF-) alpha expression is associated with early events in IP carcinogenesis [139, 140, 172–174]. …”

“…Clinically benign behavior was related to the presence of inflammatory polyp and the absence of hyperkeratosis, predominantly mucinous tumors, a mitotic index less than 1 per HPF, a ratio of neoplastic epithelium/connective tissue stroma greater than or equal to 6, and the presence of inflammatory polyps among the papillomas [89, 511]. Precancerous lesions of IP exhibited elevated levels of EGFR and TGF-alpha and this expression may be associated with early events in IP carcinogenesis [139, 140, 174]. HPV infection may be an early event in a multistep process of malignant formation of IP [110, 139, 140, 143, 144, 164, 179, 523, 524].…”