Expression of epstein-barr virus in carcinomas of major salivary glands: A strong association with lymphoepithelioma-like carcinoma

Head and Neck Cancer: Global Burden and Regional Trends in India

“…This unusual similarity can be due to more or less similar (indolent) behaviour of such tumours in terms of clinical presentation, treatment response and prognosis with less of the environmental or genetic aggression to the prevalence of this particular cancer. Although EBV has been consistently associated with lymphoepithelial carcinoma of the salivary glands in the Asian population, there is no evidence of its causal role in other primary salivary gland neoplasm (Tsai et al, 1996). The factors reported to be associated with cancer of salivary glands are prior childhood radiation of head and neck (Katz and Preston-Martin 1984), wood dust (Klitenberg et al, 1984), silica (Zheng et al, 1996), nitrosamines in rubber workers (Straif et al, 1999) and smoking (implicated in case of Warthin's tumour (Pinkston and Cole 1996)).…”

Salivary Gland Carcinoma

“…20 It constitutes a significant proportion of salivary gland carcinoma in Chinese and Eskimo populations 21,22 and is related to Epstein-Barr virus infection. 12,15,21,22 In this series, 7 (14%) of the 50 patients belonged to this histological group and all cases arose from the parotid gland. In agreement with other reports, 12,15 LELC was shown to have a better prognosis (Fig 1), and did not develop in any of the seven patients with LELC.…”

“…However, LELCs are very radiosensitive and bear a better prognosis than the other high-grade salivary gland tumours. [11][12][13] In this study, there was no cancer mortality among the patients with LELC (n=7) or acinic cell carcinoma (n=3), hence justifying the grouping of these two histological types to analyse survival and relapse. Therefore, despite the poor differentiation and highgrade histological appearance of LELC, its clinical course and behaviour were benign in this study.…”

“…5,6 The prognosis depends on the stage [5][6][7][8] and grade 3,4,9 of the cancer, the completeness of surgical resection, and, when the resection is incomplete, whether or not postoperative radiotherapy is administered. [1][2][3]6,10 Unlike other high-grade salivary gland carcinomas, lymphoepithelioma-like carcinomas (LELCs) are very radiosensitive, [11][12][13] and radiotherapy has been used instead of surgery as the primary treatment of LELC. 11 In addition, the prognosis of LELC in Hong Kong is good: the 5-year control rate exceeds 90% and the 4-year disease-free survival rate is higher than 80%.…”

“…11 In addition, the prognosis of LELC in Hong Kong is good: the 5-year control rate exceeds 90% and the 4-year disease-free survival rate is higher than 80%. 12 This study aimed to evaluate the significance of (a)various factors such as the cancer stage, the administration of postoperative radiotherapy, the presence of positive or close resection margins, and the histological types in the prognosis of salivary gland carcinoma; (b) the pattern of treatment failure; and (c) the natural course of LELC.…”