Lymphoepithelioma-like carcinoma of the uterine cervix

Tseng, Chen‐Kan; Pao, Chia C.; Tseng, Ling-Hong; Chang, Chang-Ting; Lai, Chyong-Huey; Soong, Yung‐Kuei; Hsueh, Swei; Jyu-Jen, B S Hor

doi:10.1002/(sici)1097-0142(19970701)80:1<91::aid-cncr12>3.0.co;2-a

Cited by 77 publications

(28 citation statements)

References 22 publications

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“…Despite of the fact of a strong p16 positivity, immunohistochemistry of HPV was negative. There is some controversy about HPV related LELC [25,13,14], but a few reports give evidence for this possible pathogenesis in the uterine cervix [8,10]. Lichen sclerosus is a further precursor lesion of vulvar carcinoma, but we did not find lichenoid changes in the stromal compartments of the excision specimen.…”

Section: Discussioncontrasting

confidence: 53%

“…Whereas the neoplasms of the upper aerodigestive tract are EBV-related, the most cases of LELC described so far were EBV negative [8-11], especially those in the skin and extracervical gynaecological sites [20-23]. Only very few reports could figure out a correlation between EBV and LELC of the uterine cervix [13,14]. With a negative EBV in-situ hybridisation this pathway could be excluded for our patient.…”

Section: Discussionmentioning

confidence: 86%

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Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

et al. 2011

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This report describes an unusual EBV-negative lymphoepithelioma-like carcinoma of the vulva in a 73-year-old patient. The lesion was localised at the right minor labium and was resected by partial vulvectomy. A synchronous sentinel lymph node biopsy revealed a single micrometastasis in the right inguinal region, which prompted local radiotherapy. Follow-up nine months later showed only slight vulvar atrophy, without signs of local recurrence or distant metastases.Although lymphoepithelioma-like carcinomas of the skin and the female genital tract are presumed to have a better prognosis than their counterparts in the upper aerodigestive tract, possibly due to earlier detection and therapy, this case documents their potential for early metastasis.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 86%

Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

et al. 2011

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“…Tseng et al [20] reported a high incidence of EBV in lymphoepithelial like-carcinoma (LELC) patients but did not show any association with HPV. These findings are in contradiction with what has been previously reported [21,22].…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus and Epstein-Barr virus co-infection in Cervical Carcinoma in Algerian women

Khenchouche

Sadouki

Boudriche³

et al. 2013

Virol J

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BackgroundDespite the fact that the implication of human papillomavirus (HPV) in the carcinogenesis and prognosis of cervical cancer is well established, the impact of a co-infection with high risk HPV (HR-HPV) and Epstein-Barr virus (EBV) is still not fully understood.MethodsFifty eight randomly selected cases of squamous cell carcinomas (SCC) of the uterine cervix, 14 normal cervices specimens, 21 CIN-2/3 and 16 CIN-1 cases were examined for EBV and HPV infections. Detection of HR-HPV specific sequences was carried out by PCR amplification using consensus primers of Manos and by Digene Hybrid Capture. The presence of EBV was revealed by amplifying a 660 bp specific EBV sequence of BALF1. mRNA expression of LMP-1 in one hand and protein levels of BARF-1, LMP-1 and EBNA-1 in the other hand were assessed by RT-PCR and immunoblotting and/or immunohischemistry respectively.ResultsHR-HPV infection was found in patients with SCC (88%), low-grade (75%) and high grade (95%) lesions compared to only 14% of normal cervix cases. However, 69%, 12.5%, 38.1%, and 14% of SCC, CIN-1, CIN-2/3 and normal cervix tissues, respectively, were EBV infected. The highest co-infection (HR-HPV and EBV) was found in squamous cell carcinoma cases (67%). The latter cases showed 27% and 29% expression of EBV BARF-1 and LMP-1 oncogenes respectively.ConclusionThe high rate of HR-HPV and EBV co-infection in SCC suggests that EBV infection is incriminated in cervical cancer progression. This could be taken into account as bad prognosis in this type of cancer. However, the mode of action in dual infection in cervical oncogenesis needs further investigation.

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“…This virus infects B cells of the immune system and epithelial cells. There is evidence that infection with EBV is associated with a higher risk of particular forms of cancer and may function as an oncogenic agent (20). Thus, the association of EBV with premalignant changes, including those observed in the four patients of the current study, is worthy of investigation.…”

Section: Discussionmentioning

confidence: 99%

Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization

et al. 2013

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Squamous papilloma involving the middle ear as a primary lesion is an extremely rare occurrence. The aims of the present study were to investigate the presence of human papilloma virus (HPV) and Epstein-Barr virus (EBV) infections in primary middle ear squamous papilloma and to describe the clinical and pathological features of the disease along with therapeutic strategies. A retrospective review was conducted of four patients with clinical and pathological diagnoses of middle ear squamous papilloma. In situ hybridization (ISH) for a wide range of HPV DNA subtypes and EBV-encoded RNA was performed in the tissue samples obtained from these patients. Only two cases of primary squamous papilloma in the middle ear have been previously reported in the English literature. These papillomas developed in males of ~60-years of age and otorrhea was the most frequent complaint. Premalignant changes were observed in two of the present cases and ISH of HPV and EBV was negative in all four cases. The results of the present study indicated that chronic inflammatory stimulation, not HPV and EBV infection, is involved in the occurrence of middle ear squamous papilloma and its malignant transformation. Radical surgery and long-term postoperative follow-up are recommended due to its malignant and recurrent potential. Further genetic investigations with additional new cases are required to clarify the pathogenesis of squamous papilloma involving the middle ear.

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Lymphoepithelioma-like carcinoma of the uterine cervix

Cited by 77 publications

References 22 publications

Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique

Human Papillomavirus and Epstein-Barr virus co-infection in Cervical Carcinoma in Algerian women

Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization

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