Expression of estrogen receptor (ER) in oral mucosa and salivary glands

Leimola‐Virtanen, Riitta; Salo, Tuula; Toikkanen, Sakari; Pulkkinen, Jaakko; Syrjänen, Stina

doi:10.1016/s0378-5122(00)00138-9

Cited by 104 publications

(86 citation statements)

References 22 publications

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“…Human gingiva has been shown to contain receptors for estradiol by autoradiography using radioactively labeled estradiol (Vittek et al 1982a) and oral mucosa has been shown to express ER mRNA (Leimola-Virtanen et al 2000). In a single study, the presence of ERs in healthy gingiva has been demonstrated by immunohistochemistry (IHC), although the subtype was not determined (Forabosco et al 1992).…”

Section: Introductionmentioning

confidence: 99%

“…In a single study, the presence of ERs in healthy gingiva has been demonstrated by immunohistochemistry (IHC), although the subtype was not determined (Forabosco et al 1992). However, other IHC-based studies have been unable to confirm this finding (Ojanotko-Harri et al 1992, Leimola-Virtanen et al 2000. Studies investigating the presence of ERs in salivary glands have also given conflicting results.…”

Section: Introductionmentioning

confidence: 99%

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Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa

Savolainen

Soukka

et al. 2004

Journal of Endocrinology

181

149

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Many studies have shown that the oral mucosa and salivary glands are sensitive to estrogen action. However, the expression of estrogen receptors (ERs) within these tissues is an area of controversy. ERs exist as two subtypes (ER and ER ), and we hypothesized that the incongruity between ER expression and estrogen sensitivity may result from differential expression of ER subtypes in oral tissues. To test this hypothesis, we analyzed oral mucosal and salivary gland samples for ER and ER protein expression by immunohistochemistry from a cross-section of patients attending hospital for surgical problems of the head and neck. ER was not detected in oral buccal and gingival epithelium or in salivary glands. In contrast, ER was widely expressed at high levels in all oral tissues studied. Within these tissues, ER was observed primarily in keratinocytes and salivary gland acinar and ductal cells. Our results demonstrating the expression of only the ER subtype within oral tissues may explain the contradictory results from previous studies investigating ER expression in these tissues. Importantly, these results suggest that estrogens may act via ER in oral tissues and explain the effect of hormonal changes on the oral mucosa as well as on saliva secretion and composition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands

Välimaa

Savolainen

Soukka

et al. 2004

Journal of Endocrinology

181

149

View full text Add to dashboard Cite

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“…The immune-peroxidase technique (in accordance with previous descriptions by Kuiper et al, Paech et al;Leimola-Virtanen et al, 2000;Zafrani et al, 2000;Pavao et al) was applied using the standard methodology for immunohistochemistry. The analysis was developed at the Laboratory of the Pathology and Morphology Departments of the School of Medical Sciences of Santa Casa de São Paulo, Brazil.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, this hormone is also known to have a role in modulating neurogenic inflammatory reactions (Bjorling & Wang, 2001). In the oral mucosa, estrogen improves the activity of salivary secretion (Leimola-Virtanen, 2000, Välimaa et al, 2004. In conjunctiva, estrogen can induce changes in allergic responses and maturation of goblet cells and epithelium (Fuchsjäger-Mayrl, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…In 1958, Elwood Jensen discovered the first estrogen receptor, which was cloned in 1986 and named the alpha receptor (Green et al, 1986) Ten years later, in 1996, a second estrogen receptor was discovered and named beta (Kuiper et al, 1997). Subsequently, several studies on these two isoforms of estrogen receptors have shown that they are highly specific in humans and enable selective hormonal action on different tissues (Peach et al;Mosselman et al, 1996;Kuiper et al).…”

Section: Introductionmentioning

confidence: 99%

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Inmunohistochemical Evaluation of Estrogen Receptors Alpha and Beta in Normal Inferior Turbinate Mucosa

Millas¹,

Liquidato²,

Dolci³

et al. 2010

Int. J. Morphol.

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SUMMARY:It has been postulated that the nasal mucosa, like other human tissues, is affected by a complex interactive network of neuropeptides, cytokines, allergic and inflammatory mediators and hormones such as estrogen, in which associations between symptoms (e.g. nasal stuffiness and coryza) and hormonal variations deriving from pregnancy, use of hormonal contraceptives and menstrual cycle phases are observed. The objective is evaluating the presence of specific estrogen receptors (types alpha and beta) in inferior turbinate mucosa in healthy subjects without nasal symptoms. Samples of nasal inferior turbinate were removed from patients undergoing aesthetic nasal surgery, and analyzed using hematoxylin-eosin staining, followed by immunohistochemical preparations on paraffin-embedded sections from the material sample, to detect estrogen receptors alpha and beta. Positive immunohistochemical reactions for both beta

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