Expression of estrogen receptor in hemangioma of the uterine cervix: reports of three cases and review of the literature

Abstract

The occurrence of hemangioma in the female genital tract, particularly in uterine cervix, is rare. The majority of them show asymptomatic behavior. Surgical excision remains curative in most of the cases. Conservative therapies such as sclerosing agents, cryotherapy, and CO(2) laser excision may be alternatively applied. We present three cases of hemangiomas of the cervix in asymptomatic women, diagnosed as cavernous hemangioma in two cases and capillary hemangioma in one. All tumors were immunoreactive for CD31, CD34, factor-VIII-related antigen. Focal expression of estrogen receptors was detected. No positivity was obtained with progesterone receptor antibodies. The presence of estrogen receptor in the endothelial cells of the hemangioma of the cervix suggests a direct role of this hormone in the hemangioma development. A possible target therapy is discussed.

Cavernous hemangioma of the cervix and pregnancy: a case report

“…It can touch many internal organs such as the liver, the spleen, the pancreas, the gastrointestinal tract, the skin, the uterus and sometimes the brain. The cervical localization is rare [1][2][3][4][5][6][7][8][9][10][11][12]. In Table 1, we present 15 cases found in the literature.…”

“…Reggiani Bonetti [6] 2009 3 cases of haemangioma of the cervix in asymptomatic women, diagnosed as cavernous haemangioma. All tumors were immunoreactive for CD31, CD34, and factor-VIII-related antigen.…”

“…The presence of estrogen receptor in the cervix haemangioma endothelial cells suggests a direct role of this hormone in haemangioma development. A possible target therapy is discussed [6].…”

“…Its seat is primarily visceral and generally hepatic [1,[2][3][4]. This cervical lesion may cause vaginal metrorrhagia or pains [1,[2][3][4][5][6][7][8][9]. It seems that the tumor can vary.…”

“…The obstetrical complications are the premature rupture of membranes, the fetal death in the uterus, the postpartum haemorrhage and disseminated intravascular coagulation [3][4][5][11][12][13]. The dilemma that may arise is the delivery way in a pregnant mother having a cervical cavernous haemangioma [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. In this report, we describe a haemangioma of the uterine cervix in a 25-year old multiparous patient, who presented premature labor with membranes rupture in the 33 -34 gestational weeks.…”