Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer

Tang, Wenbo; Liu, Rujiao; Yan, Yan; Pan, Xiaoli; Wang, Minjun; Han, Xiaotian; Ren, Hui; Zhang, Zhe

doi:10.18632/oncotarget.16582

Cited by 58 publications

(55 citation statements)

References 29 publications

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“…Increased serum phytoestrogen concentrations have also been shown to be inversely correlated to risk of gastric cancer in a study of male and female Korean individuals [78]. Furthermore, Chinese ERα positive gastric cancer patients, had a significantly worse prognosis compared to those that were ERβ positive [79]. The most well characterized correlation between cancer incidence and phytoestrogen consumption is found in breast cancer.…”

Section: Cancer and Phytoestrogensmentioning

confidence: 98%

Estrogen–gut microbiome axis: Physiological and clinical implications

2017

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Low levels of gonadal circulating estrogen observed in post-menopausal women can adversely impact a diverse range of physiological factors, with clinical implications for brain cognition, gut health, the female reproductive tract and other aspects of women's health. One of the principal regulators of circulating estrogens is the gut microbiome. This review aims to shed light on the role of the gut microbiota in estrogen-modulated disease. The gut microbiota regulates estrogens through secretion of β-glucuronidase, an enzyme that deconjugates estrogens into their active forms. When this process is impaired through dysbiosis of gut microbiota, characterized by lower microbial diversity, the decrease in deconjugation results in a reduction of circulating estrogens. The alteration in circulating estrogens may contribute to the development of conditions discussed herein: obesity, metabolic syndrome, cancer, endometrial hyperplasia, endometriosis, polycystic ovary syndrome, fertility, cardiovascular disease (CVD) and cognitive function. The bi-directional relationship between the metabolic profile (including estrogen levels) and gut microbiota in estrogen-driven disease will also be discussed. Promising therapeutic interventions manipulating the gut microbiome and the metabolic profile of estrogen-driven disease, such as bariatric surgery and metformin, will be detailed. Modulation of the microbiome composition subsequently impacts the metabolic profile, and vice versa, and has been shown to alleviate many of the estrogen-modulated disease states. Last, we highlight promising research interventions in the field, such as dietary therapeutics, and discuss areas that provide exciting unexplored topics of study.

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Section: Cancer and Phytoestrogensmentioning

confidence: 98%

Estrogen–gut microbiome axis: Physiological and clinical implications

2017

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“…Non-genomic estrogen signaling mediated by ER-α was involved in the c-Src signaling pathway in SGC7901 GC cells (66). A recent study found that ERα expression in gastric cancer cells was increased by low concentrations of 17β-estradiol, which in turn resulted in increased proliferation by activating mitogen-activated protein kinase signaling pathway (67). In addition, knock down of ERα did not affect the proliferation, migration and invasion of gastric cancer cells (67).…”

Section: Gastric Cancer (Gc)mentioning

confidence: 98%

“…A recent study found that ERα expression in gastric cancer cells was increased by low concentrations of 17β-estradiol, which in turn resulted in increased proliferation by activating mitogen-activated protein kinase signaling pathway (67). In addition, knock down of ERα did not affect the proliferation, migration and invasion of gastric cancer cells (67). Compared with expression of ERα, expression of ERβ in noncancerous tissues was significantly higher in female rats compared with male rats (68).…”

Section: Gastric Cancer (Gc)mentioning

confidence: 99%

The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)

et al. 2019

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Estrogen is an important sex steroid hormone which serves an important role in the regulation of a number of biological functions, including regulating bone density, brain function, cholesterol mobilization, electrolyte balance, skin physiology, the cardiovascular system, the central nervous system and female reproductive organs. Estrogen exhibits various functions through binding to its specific receptors, estrogen receptor α, estrogen receptor β and G protein-coupled estrogen receptor 1. In recent years, researchers have demonstrated that estrogen and its receptors serve an important role in the gastrointestinal (GI) tract and contribute to the progression of a number of GI diseases, including gastroesophageal reflux, esophageal cancer, peptic ulcers, gastric cancer, inflammatory bowel disease, irritable bowel syndrome and colon cancer. The aim of this review is to provide an overview of estrogen and its receptors in GI disease, and highlight potential avenues for the prevention and treatment of GI diseases.

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“…Thus, the observed up-regulation of UBE2M and UBA3 in esophageal squamous cell carcinomas and intrahepatic cholangiocarcinoma could be repeated in gastric cancer as another organ of the digestive system. On the other hand, recently researchers proved the estrogen receptors (ERα, ERβ) involvement in the progression of gastric cancer by affecting P21, P27, P53, and E-Cadherin expressions (Tang et al 2017). Furthermore, several studies reported a decrease in the expression of these receptors related to poor prognosis of gastric cancer (Tang et al 2017).…”

Section: Predicted Driver Genes Of Hereditary Gastric Cancermentioning

confidence: 99%

“…On the other hand, recently researchers proved the estrogen receptors (ERα, ERβ) involvement in the progression of gastric cancer by affecting P21, P27, P53, and E-Cadherin expressions (Tang et al 2017). Furthermore, several studies reported a decrease in the expression of these receptors related to poor prognosis of gastric cancer (Tang et al 2017). UBE2M and UBA3 are factors that their overexpression downregulate the estrogen receptors expression (Fan et al 2003).…”

Section: Predicted Driver Genes Of Hereditary Gastric Cancermentioning

confidence: 99%

TOPDRIVER: the novel identifier of cancer driver genes in Gastric cancer and Melanoma

et al. 2019

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Nowadays, research has found a strong relationship between genomic status and occurrence of disease. Cancer is one of the most common diseases that leads to a high annual mortality rate worldwide, and the disease's genetic content remains challenging. Detecting driver genes of different cancers could help in early diagnosis and treatment. In this paper, we proposed TOPDRIVER, a network-based algorithm, to detect cancer driver genes in cancers. An initial network was constructed by integrating four different omic datasets: HPRD, NCBI, KEGG, and GTEx. This integration created a gene similarity profile that provided a comprehensive perspective of gene interaction in each subtype of cancer and allocated weights to the edges of the network. The vertex scores were calculated using a gene-disease association dataset (DisGeNet) and a molecular functional disease similarity. In this step, the genes network was jagged and faced with a zero-one gap problem. A diffusion kernel was implemented to smooth the vertex scores to overcome this problem. Finally, potential driver genes were extracted according to the topology of the network, genes overall biological functions, and their involvement in cancer pathways. TOPDRIVER has been applied to two subtypes of gastric cancer and one subtype of melanoma. The method could nominate a considerable number of well-known driver genes of these cancers and also introduce novel driver genes. NKX3-1, KIDINS220, and RIPK4 have introduced for gastrointestinal cancer, UBA3, UBE2M, and RRAGA for hereditary gastric cancer and CIT for invasive melanoma. Biological evidences represents TOPDRIVER's efficiency in a subtype-specific manner.

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Expression of estrogen receptors and androgen receptor and their clinical significance in gastric cancer

Cited by 58 publications

References 29 publications

Estrogen–gut microbiome axis: Physiological and clinical implications

Estrogen–gut microbiome axis: Physiological and clinical implications

The roles of estrogen and estrogen receptors in gastrointestinal disease (Review)

TOPDRIVER: the novel identifier of cancer driver genes in Gastric cancer and Melanoma

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