Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach

Shin, Masahiro; Watanuki, Kumiko; Yasugi, Sadao

doi:10.1016/j.modgep.2004.12.004

Cited by 15 publications

(15 citation statements)

References 13 publications

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“…The digestive tract (DT) of chicken embryos (Gallus gallus) begins to develop on the first day of incubation (Shin et al, 2005). At first it is represented by a simple and undifferentiated tube (Klasing, 1999;Smith et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Histological Description of Morphogenesis of the Gastroesophageal Mucosa of Gallus gallus domesticus (Linnaeus, 1758)

Ventura¹,

Nascimento²,

Santos³

et al. 2013

Int. J. Morphol.

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SUMMARY:The ontogenesis of the gastroesophageal mucosa involves morphological alterations related to its structure and the function of each segment. The present study describes the histogenesis of the mucus-secreting epithelium and glands of the esophagus, gizzard, and proventriculus of the chicken (Gallus gallus), and identifies alterations in the secretion pattern of glycosaminoglycans (GAG's). We analyzed 38 chicken embryos, processed the material collected following the histological routine, and then stained it with hematoxylin-eosin for the analysis of tissue structure and with Gomori's trichrome for the identification of conjunctive tissue and collagen fibers. We used the PAS histochemical technique for the analysis of neutral GAG's and the AB pH 2.5 histochemical technique for the analysis of acid GAG's. The embryos at late stage of development had the esophagus wall composed of four layers: mucosa, submucosa, muscularis, and serosa, whereas the proventriculus and the gizzard were composed of three layers: mucosa, muscularis, and serosa. In all three segments, we identified the superficial epithelium as mucus-secreting; in the esophagus this epithelium was mucussecreting only at the initial development stages. The proventricular glands began to form at the initial development stages, whereas the tubular glands began to form in the gizzard just after the 15th day. The differences in the production of GAG's in these regions of the digestive tract are related to development stages, functions, and physiological requirements of each segment, and to the gradual adjustment of the body to the post-hatching life.

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Section: Introductionmentioning

confidence: 99%

Histological Description of Morphogenesis of the Gastroesophageal Mucosa of Gallus gallus domesticus (Linnaeus, 1758)

Ventura¹,

Nascimento²,

Santos³

et al. 2013

Int. J. Morphol.

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“…Bone morphogenetic protein 2 (BMP2), which is secreted from the surrounding mesenchyme, is an important inducer of gland formation and ECPg expression (Narita et al, 2000). Fgf10, which is expressed in PV mesenchyme (Shin et al, 2005), regulates epithelial cell proliferation and differentiation (M. Shin, S. Noji and S. Yasuji, unpublished). Fukuda et al (Fukuda et al, 2003) have shown that a downregulation of Sonic hedgehog (Shh) expression in the epithelium is necessary for gland formation.…”

Section: Introductionmentioning

confidence: 99%

Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

et al. 2005

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“…To further elucidate the expression patterns of FgfR1 and FgfR3 isoforms, in situ hybridization probes were prepared using the amplification products obtained upon RT-PCR performed on total RNA extracted from HH24 whole chick embryos, using the primers previously described (Shin et al 2005). The amplicon sequences were determined and deposited in GenBank with the following accession numbers: FgfR1IIIb-GU053725; FgfR1IIIc-GU065444; FgfR3IIIb-GU053726; FgfR3IIIc-GU065445.…”

Section: Isoform-specific Expression Patterns Of Fgfrs 1-3mentioning

confidence: 99%

“…We employed the same experimental approach as Shin et al (2005) to detect the presence of the specific IIIb and IIIc isoforms of FgfR1-3 in segregated ectoderm and mesoderm in the mesenchyme (Fig. 4), so detailed FgfR3 isoform-specific expression patterns in the limb mesenchyme are missing.…”

Section: Isoform-specific Expression Patterns Of Fgfrs 1-3mentioning

confidence: 99%

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Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development

Sheeba¹,

Andrade²,

Duprez³

et al. 2010

Int. J. Dev. Biol.

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Specific interactions between fibroblast growth factors (Fgf1-22) and their tyrosine kinase receptors (FgfR1-4) activate different signalling pathways that are responsible for the biological processes in which Fgf signalling is implicated during embryonic development. In the chick, several Fgf ligands (Fgf2, 4, 8, 9, 10, 12, 13 and 18 ) and the four FgfRs (FgfR 1, 2, 3 and 4) have been reported to be expressed in the developing limb. The precise spatial and temporal expression of these transcripts is important to guide the limb bud to develop into a wing/leg. In this paper, we present a detailed and systematic analysis of the expression patterns of FgfR1, 2, 3 and 4 throughout chick wing development, by in situ hybridisation on whole mounts and sections. Moreover, we characterize for the first time the different isoforms of FGFR1-3 by analysing their differential expression in limb ectoderm and mesodermal tissues, using RT-PCR and in situ hybridisation on sections. Finally, isoform-specific sequences for FgfR1IIIb, FgfR1IIIc, FgfR3IIIb and FgfR3IIIc were determined and deposited in GenBank with the following accession numbers: GU053725, GU065444, GU053726, GU065445, respectively. KEY WORDS: Fgf, FgfRs, limb, chickThe developing chick limb grows out as a protrusion of mesenchymal cells from the lateral plate mesoderm and adjacent somites. Cells from the lateral plate mesoderm form cartilage and connective tissues, such as muscle sheaths, tendons and ligaments. Meanwhile, myogenic precursor cells delaminate from the lateral part of the somites, migrate to the limb bud, colonise the dorsal and ventral limb regions and activate the myogenic program to differentiate into multinucleated myotubes, thus generating the definitive limb skeletal muscles (Christ and Brand-Saberi, 2002;Duprez, 2002;Buckingham et al. 2003). The mesenchyme of the limb bud is enveloped by an ectodermal jacket, whose distal tip forms a specialised epithelial structure, the apical ectodermal ridge (AER) (Todt and Fallon, 1984). Mesenchymal cells directly under the AER remain undifferentiated and populate the so-called undifferentiated zone (Tabin and Wolpert, 2007). Condensation of the cartilage elements proceeds in a proximal to distal direction based on cells' temporal and positional values, which could be provided by the reported limb molecular clock (Pascoal et al. 2007a; reviewed in Pascoal and Palmeirim, 2007;Tabin and Wolpert, 2007).Int. J. Dev. Biol. 54: 1517-1526 (2010) doi: 10.1387/ijdb.092887cs Abbreviations used in this paper: AER, apical ectodermal ridge; Fgf, fibroblast growth factor; FgfR, Fgf receptor; ZPA, zone of polarizing activity.During development, changes occur along the three limb bud axes -anterior-posterior (AP), dorsal-ventral (DV) and proximaldistal (PD) -conducted by three distinct signalling centres, the zone of polarizing activity (ZPA), the dorsal (non-ridge) ectoderm and the AER, respectively (reviewed in Towers and Tickle, 2009). ZPA activity is mediated by the diffusible molecule Sonic hedgehog (Shh...

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Expression of Fgf10 and Fgf receptors during development of the embryonic chicken stomach

Cited by 15 publications

References 13 publications

Histological Description of Morphogenesis of the Gastroesophageal Mucosa of Gallus gallus domesticus (Linnaeus, 1758)

Histological Description of Morphogenesis of the Gastroesophageal Mucosa of Gallus gallus domesticus (Linnaeus, 1758)

Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development

Comprehensive analysis of fibroblast growth factor receptor expression patterns during chick forelimb development

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