Expression of follicular helper T cell markers in nodal peripheral T cell lymphomas: a tissue microarray analysis of 162 cases

Zhan, He Qin; Li, Xiao Qiu; Zhu, Xianjun; Lü, Hong; Zhou, Xiao Yan; Chen, Yan

doi:10.1136/jcp.2010.084459

Cited by 38 publications

(37 citation statements)

References 23 publications

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“…15,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] These include angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma with a follicular growth pattern, primary cutaneous CD4( þ ) small/ medium-sized pleomorphic T-cell lymphoma and, occasionally, peripheral T-cell lymphoma, not otherwise specified and anaplastic large cell lymphoma. 15,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Clinically, primary cutaneous CD4( þ ) small/ medium-sized pleomorphic T-cell lymphoma and angioimmunoblastic T-cell lymphoma present or may present with primary cutaneous involvement. 20,[36][37][38][39][40] Other CD4( þ ) T-cell lymphomas with primary cutaneous manifestations include mycosis fungoides and its variants including Sezary syndrome, adult T-cell leukemia/lymphoma and primary cutaneous CD30 þ lymphoproliferative disorders.…”

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confidence: 99%

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

et al. 2013

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confidence: 99%

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

et al. 2013

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“…Such Tfh-like immunophenotypes have been confirmed by immunohistochemical evidence [11,12], including high expression of B cell CLL/lymphoma 6 (BCL6), programmed death-1 (PD-1), inducible T cell costimulator (ICOS), chemokine (C-X-C motif) receptor 5 (CXCR5), and chemokine (C-X-C motif) ligand 13 (CXCL13). In particular, CXCL13 expression may contribute to pathological features characteristic of AITL by recruiting B cells into the germinal center and activating them [21].…”

Section: Aitl Gene Expression Signaturesmentioning

confidence: 90%

“…Previous studies report that some PTCL-NOS tumors express factors common to Tfh [8,10,11]. A Tfh-related factors are also observed in angioimmunoblastic T cell lymphomas (AITL) [8,[11][12][13][14].…”

Section: Peripheral T Cell Lymphoma Not Otherwise Specified Ptcl-nosmentioning

confidence: 99%

“…A Tfh-related factors are also observed in angioimmunoblastic T cell lymphomas (AITL) [8,[11][12][13][14]. Gene mutation profiles of PTCL-NOS with Tfh features in fact resemble those seen in AITL [5••, 15], raising questions about what distinguishes PTCL-NOS w i t h T f h f e a t u r e s f r o m A I T L ( s e e s e c t i o n BAngioimmunoblastic T Cell Lymphoma^).…”

Section: Peripheral T Cell Lymphoma Not Otherwise Specified Ptcl-nosmentioning

confidence: 99%

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Molecular Pathogenesis of Peripheral T Cell Lymphoma

Sakata‐Yanagimoto

2015

Curr Hematol Malig Rep

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Understanding the molecular pathogenesis of peripheral T cell lymphomas (PTCLs) has lagged behind that of B cell lymphomas due to disease rarity. However, novel approaches are gradually clarifying these mechanisms, and gene profiling has identified specific signaling pathways governing PTCL cell survival and growth. For example, genetic alterations have been discovered, including signal transducer and activator of transcription (STAT)3 and STAT5b mutations in several PTCLs, disease-specific ras homolog family member A (RHOA) mutations in angioimmunoblastic T cell lymphoma (AITL), and recurrent translocations at the dual specificity phosphatase 22 (DUSP22) locus in anaplastic lymphoma receptor tyrosine kinase (ALK)-negative anaplastic large cell lymphomas (ALCLs). Intriguingly, some PTCL-relevant mutations are seen in apparently normal blood cells as well as tumor cells, while others are confined to tumor cells. These data have dramatically changed our understanding of PTCL origins: once considered to originate from mature T lymphocytes, some PTCLs are now believed to emerge from immature hematopoietic progenitor cells.

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“…PTCL-F was not grouped with AITCL in the 2008 WHO classification because of its presentation in a low-stage, partial organ involvement, lower frequency of polymorphous reactive background, and lack of hyperplastic high-endothelial venules compared with typical AITCL; however, recent accumulating clinical, morphological, and genetic evidence suggest that PTCL-F may not be a distinct entity; rather, it may represent a spectrum of AITCL [30]. Clinically, the coexistence of PTCL-F and AITCL in the same patient has been reported [31]. Some patients who were initially diagnosed with AITCL relapsed with PTCL-F [32].…”

Section: Peripheral T-cell Lymphoma Nos Follicular Variant (Ptcl-f)mentioning

confidence: 98%

Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.Epidemiology T-and NK-cell lymphomas are uncommon: overall, they represent fewer than 25 % of all non-Hodgkin's lymphoma (NHL) [1][2][3]. The occurrence rates of various subtypes of T-and NK-cell lymphomas in Asia are significantly different from those observed in Western countries, and even among Asian countries. The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %). The proportion of T-and NK-cell lymphomas in Taiwan is very low (13.3 %) compared with that of other East Asian countries. Regarding the subtypes of T-and NK-cell lymphomas, two West (Turkey and Iraq) and one South (Pakistan) Asian countries share similar distribution patterns, presenting T lymphoblastic lymphoma (T-LBL) as the most common subtype, followed by peripheral T-cell lymphoma (PTCL) or anaplastic largecell lymphoma (ALCL). The frequency of mycosis fungoides/sezary syndrome (MF/SS) is very high in Kuwait. The distribution patterns of T-and NK-cell lymphomas in Thailand, Taiwan, and Korea are similar, whereas adult T-cell leukemia/lymphoma (ATLL) represents a high proportion of T-and NK-cell lymphomas in Japan. When ATLL is excluded, four countries (Thailand, Taiwan, Korea, and Japan) exhibit very similar patterns of subtype distribution of T-and NK-cell lymphomas. Extranodal NK/ T-cell lymphoma (ENKL) is frequent in China (48 %) and Korea (28.7 %), but is less frequent in Japan (10.4 %), as reported by a recent study performed by an international T-cell project [2]. In China, the frequency of T-or NK-cell lymphoma varies according to geographic region

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Expression of follicular helper T cell markers in nodal peripheral T cell lymphomas: a tissue microarray analysis of 162 cases

Cited by 38 publications

References 23 publications

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

Follicular center helper T-cell (TFH) marker positive mycosis fungoides/Sezary syndrome

Molecular Pathogenesis of Peripheral T Cell Lymphoma

Peripheral T cell lymphoma in Asia

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