Expression of genes coding for proangiogenic factors and their receptors in human placenta complicated by preeclampsia and intrauterine growth restriction

Semczuk, M; Borczyńska, Aleksandra; Białas, Małgorzata; Rozwadowska, Natalia; Semczuk-Sikora, Anna; Malcher, Agnieszka; Kurpisz, Maciej

doi:10.1016/j.repbio.2013.03.004

Cited by 12 publications

(8 citation statements)

References 28 publications

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“…Mice lacking the expression of VEGFA or either of the 2 receptors died in utero due to inadequate vascular formation [8,9]. Aberrant placental VEGFA expression and vascular abnormalities may result in adverse pregnancy outcomes, including pregnancy loss, intrauterine fetal death, intrauterine fetal growth restriction and pre-eclampsia [10,11].…”

Section: Introductionmentioning

confidence: 99%

Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss

Lin

Chen

et al. 2014

J Assist Reprod Genet

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Section: Introductionmentioning

confidence: 99%

Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss

Lin

Chen

et al. 2014

J Assist Reprod Genet

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“…Also, Shibata and coworkers assessed PlGF concentration in placental villous homogenates by ELISA and reported it in patients about half that of the controls (28). Semczuk and coworkers studied about expression of genes coding for proangiogenic factors in women affected to PE and reported higher levels of PlGF transcription in PE patients (34). This study is the only one which reports up-regulation of PlGF mRNA in placenta of PE patients.…”

Section: Discussionmentioning

confidence: 99%

Expression of placental growth factor mRNA in preeclampsia

Nikuei

Rajaei

Malekzadeh

et al. 2017

IJRM

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Background:Preeclampsia (PE) is a serious complication of pregnancy with hallmarks of incomplete placentation, placental ischemia and endothelial dysfunction. Imbalance between vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors play important role in pathophysiology of PE. Objective:This study was aimed to asses PlGF mRNA expression in placenta of women affected with PE.Material and Methods:In this cross-sectional study, expression of PlGF mRNA was evaluated in 26 mild PE cases, 15 severe preeclamptic women and 20 normotensive controls. Patients were sub-classified as early onset PE (9) and late onset (32). After RNA extraction, PlGF expression was quantified with qRT-PCR. Results:The results of PlGF mRNA expression between mild-severe, and early-late onset PE patients showed no statistically significant difference compared with the control group (p=0.661, p=0.205 respectively).Conclusion:Despite we found no distinct differential expression of PlGF mRNA in placental tissue of PE patients compared with control women, but according to decreased level of this angiogenic factor in PE even before clinical onset of the disease, determining molecular mechanisms related to reduced secretion of PlGF into the maternal circulation may be useful for future therapeutics.

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“…However, infants with abnormalities in both cord blood VEGF/sFlt-1 and placental vascular histology were more likely to have PGF than either marker alone. While it is possible that growth factors are up-regulated by placental dysfunction [32], further studies are needed to understand this complex interplay and whether these factors are responsible for fetal growth, or merely markers of intrauterine pathology leading to growth problems.…”

Section: Discussionmentioning

confidence: 99%

Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth: A preterm birth cohort study

Voller

Chock

Ernst

et al. 2014

Early Human Development

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Background Preterm infants are at risk for postnatal growth failure (PGF). Identification of biomarkers that are associated with neonatal growth may help reduce PGF and associated long-term morbidity. Objective To investigate the associations between cord blood vascular endothelial growth factor (VEGF) and its soluble receptor (sFlt-1) with birth weight (BW) and postnatal growth in premature infants. Study Design and Methods From an ongoing birth cohort, 123 premature infants from 23 to 36 weeks gestational age (GA) were studied. Cord blood plasma VEGF and sFlt-1 were measured via enzyme-linked immunoassay. Growth parameters and nutritional information were evaluated. Multivariate logistic regression models were constructed to evaluate the associations of VEGF and sFlt-1 on PGF, defined as weight < 10th percentile at 36 weeks corrected age or discharge. Results VEGF was positively correlated, and sFlt-1 was negatively correlated with BW and BW-for-GA percentiles. Higher cord blood VEGF levels were associated with reduced risk of PGF (OR=0.7; 95% CI=0.5–0.9), while higher sFlt-1 levels appeared to increase the risk of PGF (OR=1.6; 95% CI=1.1–2.4). The above biomarker associations were attenuated after adjustment for maternal preeclampsia, fetal growth restriction and related neonatal characteristics, and when taking into account placental vascular pathologies. Longitudinal growth patterns by mean weight and length percentiles were consistently lower among infants with low VEGF/sFlt-1 ratios. Conclusions Our data support that intrauterine regulation of angiogenesis is an important mechanism of fetal and postnatal growth. Cord blood VEGF and sFlt-1 are useful in elucidating how intrauterine processes may have long-standing effects on developing premature infants.

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Expression of genes coding for proangiogenic factors and their receptors in human placenta complicated by preeclampsia and intrauterine growth restriction

Cited by 12 publications

References 28 publications

Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss

Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss

Expression of placental growth factor mRNA in preeclampsia

Cord blood biomarkers of vascular endothelial growth (VEGF and sFlt-1) and postnatal growth: A preterm birth cohort study

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