Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss

Su, Mei Tsz; Lin, Sheng Hsiang; Chen, Yi Chi; Kuo, Pao Lin

doi:10.1007/s10815-014-0223-2

Cited by 27 publications

(21 citation statements)

References 39 publications

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“…Perhaps VEGF-related genes like PROK1 will provide clues to help unravel the complex associations among VEGF, cerebrovascular disease, and AD. Future work validating the interaction observed here and investigating gene-gene interactions previously reported between PROK1 and VEGF (Su, Lin, Chen, & Kuo, 2014) may help move the field forward.…”

Section: Discussionsupporting

confidence: 70%

Genetic resilience to amyloid related cognitive decline

Hohman

Dumitrescu

Cox

et al. 2016

Brain Imaging and Behavior

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Preclinical Alzheimer's disease (AD) is characterized by amyloid deposition in the absence of overt clinical impairment. There is substantial heterogeneity in the long-term clinical outcomes among amyloid-positive individuals, yet limited work has focused on identifying molecular factors driving resilience from amyloid-related cognitive impairment. We apply a recently developed predicted gene expression analysis (PrediXcan) to identify genes that modify the association between baseline amyloid deposition and longitudinal cognitive changes. Participants free of clinical AD (n=631) were selected from the AD Neuroimaging Initiative (ADNI) who had a baseline positron emission tomography measure of amyloid deposition (quantified as a standard uptake value ratio), longitudinal neuropsychological data, and genetic data. PrediXcan was used to impute gene expression levels across 15 heart and brain tissues. Mixed effect regression models assessed the interaction between predicted gene expression levels and amyloid deposition on longitudinal cognitive outcomes. The predicted gene expression levels for two genes in the coronary artery (CNTLN, PROK1) and two genes in the atrial appendage (PRSS50, PROK1) interacted with amyloid deposition on episodic memory performance. The predicted gene expression levels for two additional genes (TMC4 in the basal ganglia and HMBS in the aorta) interacted with amyloid deposition on executive function performance. Post-hoc analyses provide additional validation of the HMBS and PROK1 effects across two independent subsets of ADNI using two additional metrics of amyloid deposition. These results highlight a subset of unique candidate genes of resilience and provide evidence that cell-cycle regulation, angiogenesis, and heme biosynthesis likely play a role in AD progression.

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Section: Discussionsupporting

confidence: 70%

Genetic resilience to amyloid related cognitive decline

Hohman

Dumitrescu

Cox

et al. 2016

Brain Imaging and Behavior

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“…In turn, VEGFA is identified as the most important angiogenic glycoprotein playing a critical role in angiogenesis of placenta and fetus and is produced by different feto/maternal cell types like endometrium and trophoblastcells . Furthermore, VEGF are believed to regulate endothelial cell proliferation, implantation of embryo, placenta formation and fetal development …”

Section: Introductionmentioning

confidence: 99%

“…6,7 Furthermore, VEGF are believed to regulate endothelial cell proliferation, implantation of embryo, placenta formation and fetal development. 6,8 In turn, connexin 43 (Cx43) is considered as another protein that regulates cell proliferation and differentiation 9 and its role in embryonic implantation and placenta formation is well recognized. 10 It is expressed in endometrium stromal cells during early pregnancy and is necessary for proper uterine angiogenesis and decidualization.…”

Section: Introductionmentioning

confidence: 99%

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Sajjadi

Ghandil

Shahbazian

et al. 2020

J of Obstet and Gynaecol

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Aim Idiopathic recurrent spontaneous miscarriage (IRSM) is one of the pregnancy outcomes that affects 1–2% of women trying to conceive. Specific genotype or aberrant expression of vascular endothelial growth factor A (VEGFA) and connexin 43 (Cx43) as two important genes for embryonic development are deemed to increase the risk of IRSM. Methods To investigate any possible association of VEGFA polymorphisms and aberrant expression of Cx43 and VEGFA with IRSM, we carried out a case–control study including embryo chorionic villus tissues of 100 pregnant women with IRSM and 100 embryo chorionic villus tissues of healthy pregnant women without history of miscarriage. Restriction fragment length polymorphism was used for genotyping of rs699947 (−2578C/A) and rs2010963 (−634G/C) polymorphisms in VEGFA. Besides, quantitative real‐time PCR was performed for VEGFA and Cx43 expression analysis. Results The results showed that the frequency of −634G/C and C/C genotypes was significantly higher in aborted fetuses (P = 0.001 and P < 0.001, respectively) compared to the control group's. However, the frequency of −2578C/A genotypes was not significantly different between the cases and controls. Moreover, a significant higher expression of VEGF (P = 0.0005) and Cx43 (P = 0.0011) was observed in chorionic villus tissues of women with IRSM. Conclusion The finding demonstrated that IRSM frequency may depend on GC and CC genotypes of rs2010963 VEGF polymorphism and expression level of VEGF and Cx43 in IRSM patients was increased.

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“…Thus, EG-VEGF is considered to be the human orthologue of VPRA. Other members of this family include Bv8 [14], the secreted protein from the frog Bombina variegata , its mammalian orthologues [15, 16]. Also included herein is the digestive enzyme colipase [13] and the protein Dickkopf [3, 17, 18], which is an inhibitor of Wnt signaling.…”

Section: The Basic Structure Of Eg-vegfmentioning

confidence: 99%

“…The same authors stated that, because its regulation by hypoxia and its complementary expression localisation to that of VEGF, EG-VEGF is involved in the pre-eclampsia pathogenesis. Recently published papers gave new insights into the EG-VEGF involvement in normal and pathological placental angiogenesis [12] and, maybe more important, its dysregulations impeding trophoblast proliferation and its decidual invasion [14] or pregnancy loss [15]. Also, the expression of both factors, VEGF and EG-VEGF, was identified in adrenal carcinomas.…”

Section: Brief Overview Of Eg-vegf: Its Expression and Functionsmentioning

confidence: 99%

Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Cancer Development and Tumor Angiogenesis

Corlan

Cîmpean

Jitariu

et al. 2017

International Journal of Endocrinology

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A lot of data suggests endocrine gland-derived vascular endothelial growth factor (EG-VEGF) to be restricted to endocrine glands and to some endocrine-dependent organs. Many evidences show that EG-VEGF stimulates angiogenesis and cell proliferation, although it is not a member of the VEGF family. At the time, a lot of data regarding the role of this growth factor in normal development are available. However, controversial results have been published in the case of pathological conditions and particularly in malignant tumors. Thus, our present paper has been focused on the role of EG-VEGF in normal tissues and various malignant tumors and their angiogenic processes.

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Gene-gene interactions and gene polymorphisms of VEGFA and EG-VEGF gene systems in recurrent pregnancy loss

Cited by 27 publications

References 39 publications

Genetic resilience to amyloid related cognitive decline

Genetic resilience to amyloid related cognitive decline

Association of vascular endothelial growth factor A polymorphisms and aberrant expression of connexin 43 and VEGFA with idiopathic recurrent spontaneous miscarriage

Endocrine Gland-Derived Vascular Endothelial Growth Factor/Prokineticin-1 in Cancer Development and Tumor Angiogenesis

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