Expression of glucagon-like peptide 1 receptor in neuropeptide Y neurons of the arcuate nucleus in mice

Ruska, Yvette; Szilvásy‐Szabó, Anett; Kővári, Dóra; Kádár, Andrea; Mácsai, Lilla; Sinkó, Richárd; Hrabovszky, Erik; Gereben, Balázs; Fekete, Csaba

doi:10.1007/s00429-021-02380-y

Cited by 9 publications

(6 citation statements)

References 35 publications

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“…PYY1-36 is a gut hormone that binds to the Y1-R in pancreatic islets and central nervous system (CNS) nuclei that control appetite regulation in the brain including the brainstem area postrema (AP) and nucleus tractus solitarius (NTS), where it has an anorectic effect (Walther, Morl et al 2011). The results of recent work reveal that GLP-1R is expressed in neuropeptide Y (NPY)-positive neurons in the AP and that GLP-1 can directly or indirectly inhibit neuronal signaling in the anorexigenic NPY system via agonism of GLP-1R (Ruska, Szilvasy-Szabo et al 2022). Likewise, results from a considerable body of research revealed that PYY1-36 agonism of Y1-R plays a key role in promoting β-cell survival; this pathway has been recognized as critical to the reversal of diabetes and the recovery of impaired islet function after bariatric treatment (Guida, Stephen et al 2017, Guida and Ramracheya 2020, Lafferty, Flatt et al 2021.…”

Section: Introductionmentioning

confidence: 99%

A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss

Chichura

Elfers²,

Salameh³

et al. 2022

Preprint

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Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide biased agonists (GEP44 and GEP12) of the GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors (GLP-1R, Y1-R, and Y2-R, respectively) elicit Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets, thus revealing the counteracting effects of Y1-R and GLP-1R agonism. These agonists also promote insulin-independent Y1-R-mediated glucose uptake in muscle tissue ex vivo and more profound reductions in food intake and body weight than liraglutide when administered to diet-induced obese rats. Our findings support a role for Y1-R signaling in glucoregulation and highlight the therapeutic potential of simultaneous receptor targeting to achieve long-term benefits for millions of patients.

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Section: Introductionmentioning

confidence: 99%

A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss

Chichura

Elfers²,

Salameh³

et al. 2022

Preprint

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“…Actually, obese subjects have shown reduced levels of GLP-1 and higher weight gain [ 85 , 86 ]. A central nervous system component plays a role in the regulation of GLP-1, and GLP-1 is especially affected by GLP-1 receptor (GLP-1R) [ 87 , 88 ]. GLP-1R is abundantly detected in the hypothalamus (i.e., the ARC).…”

Section: Hormones From Enteroendocrine Cells On Feed Intake Controlmentioning

confidence: 99%

“…GLP-1R is also synthesized by the POMC neurons and GLP-1R agonists that exert direct as well as indirect effects on these neurons [ 90 , 91 ]. GLP-1R expressed in POMC neurons also indirectly affects NPY neurons [ 88 ]. According to the results of Secher et al [ 92 ], they observed that GLP-1R restricts the synapses of NPY/AgRP neurons by influencing GABAergic neurons.…”

Section: Hormones From Enteroendocrine Cells On Feed Intake Controlmentioning

confidence: 99%

Applications of Enteroendocrine Cells (EECs) Hormone: Applicability on Feed Intake and Nutrient Absorption in Chickens

Lee,

Kim

2023

Animals

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This review focuses on the role of hormones derived from enteroendocrine cells (EECs) on appetite and nutrient absorption in chickens. In response to nutrient intake, EECs release hormones that act on many organs and body systems, including the brain, gallbladder, and pancreas. Gut hormones released from EECs play a critical role in the regulation of feed intake and the absorption of nutrients such as glucose, protein, and fat following feed ingestion. We could hypothesize that EECs are essential for the regulation of appetite and nutrient absorption because the malfunction of EECs causes severe diarrhea and digestion problems. The importance of EEC hormones has been recognized, and many studies have been carried out to elucidate their mechanisms for many years in other species. However, there is a lack of research on the regulation of appetite and nutrient absorption by EEC hormones in chickens. This review suggests the potential significance of EEC hormones on growth and health in chickens under stress conditions induced by diseases and high temperature, etc., by providing in-depth knowledge of EEC hormones and mechanisms on how these hormones regulate appetite and nutrient absorption in other species.

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“…The goal of our present study was to elucidate the neuroanatomy of the GLP-1/GLP-1R system in the murine spinal cord to aid further functional studies of this system. We first examined the general distribution of Glp1r transcript with in situ hybridization, and the GLP-1R protein with immunohistological techniques, using a well-characterized, highly specific antibody 14 , 16 , 29 . Next, we correlated this distribution pattern with that of GLP-1 fibers, and investigated the existence of putative preproglucagon mRNA-expressing neurons within the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Topography of the GLP-1/GLP-1 receptor system in the spinal cord of male mice

Ruska,

Csibi,

Dorogházi

et al. 2024

Sci Rep

Self Cite

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Glucagon-like peptide-1 receptor (GLP-1R) agonists are now commonly used to treat type 2 diabetes and obesity. GLP-1R signaling in the spinal cord has been suggested to account for the mild tachycardia caused by GLP-1R agonists, and may also be involved in the therapeutic effects of these drugs. However, the neuroanatomy of the GLP-1/GLP-1R system in the spinal cord is still poorly understood. Here we applied in situ hybridization and immunohistochemistry to characterize this system, and its relation to cholinergic neurons. GLP-1R transcript and protein were expressed in neuronal cell bodies across the gray matter, in matching distribution patterns. GLP-1R-immunolabeling was also robust in dendrites and axons, especially in laminae II–III in the dorsal horn. Cerebrospinal fluid-contacting neurons expressed GLP-1R protein at exceedingly high levels. Only small subpopulations of cholinergic neurons expressed GLP-1R, including a subset of sympathetic preganglionic neurons at the rostral tip of the intermediolateral nucleus. GLP-1 axons innervated all regions where GLP-1R neurons were distributed, except laminae II–III. Scattered preproglucagon (Gcg) mRNA-expressing neurons were identified in the cervical and lumbar enlargements. The results will facilitate further studies on how GLP-1 regulates the sympathetic system and other autonomic and somatic functions via the spinal cord.

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Expression of glucagon-like peptide 1 receptor in neuropeptide Y neurons of the arcuate nucleus in mice

Cited by 9 publications

References 35 publications

A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss

A Peptide Triple Agonist of GLP-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss

Applications of Enteroendocrine Cells (EECs) Hormone: Applicability on Feed Intake and Nutrient Absorption in Chickens

Topography of the GLP-1/GLP-1 receptor system in the spinal cord of male mice

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