Expression of Glutathione S-Transferase-π in Human Ovarian Cancer as an Indicator of Resistance to Chemotherapy

Hamada, Satoko; Kamada, Masao; Furumoto, Hiroyuki; Hirao, Tsutomu; Aono, Toshihiro

doi:10.1006/gyno.1994.1055

Cited by 91 publications

(39 citation statements)

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“…Response to RT may be good (with tumor regression and no relapse) or poor with relapse. We conducted a pilot study wherein we measured serum GST levels before and after RT in carcinoma cervix patients (10)(11)(12)(13)(14)(15). The aim was to determine whether post RT GST levels as compared to pre RT levels had a relevance to relapse during the two year follow up pedod.…”

Section: Alterations In Circulating Antioxidants and Free Radical Scamentioning

confidence: 99%

Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?

Prabhu

Bhat²,

Vasudevan³

2005

Indian J Clin Biochem

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We conducted a pilot study wherein serum Glutathione-S-transferase levels were measured before and after radiotherapy in carcinoma cervix patients and correlated with response to treatment dudng a two-year follow-up period. Out of 17 patients who received radiotherapy, 9 showed a significant decrease (p< 0.005) while 8 showed significant increase (p< 0.004) in post radiotherapy glutathione-S-transferase values as compared to pre treatment values respectively. These patients were followed up for two years and we observed that 71% who had significant increase in post radiotherapy values had relapse of cancer within 2 years where as 66% of those who had significant decrease in post radiotherapy values had no evidence of relapse. This shows that alterations in serum Glutathione-Stransferase levels may help us to predict radiation response

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Section: Alterations In Circulating Antioxidants and Free Radical Scamentioning

confidence: 99%

Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?

Prabhu

Bhat²,

Vasudevan³

2005

Indian J Clin Biochem

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“…Since the reports showing that GST-pi was significantly increased in proliferative hepatic nodule induced by chemical carcinogen and in well differentiated carcinoma [1] , more studies have shown [2][3][4] that GST-pi expressed highly in neoplasm, and could be rega rded as a tumor marker. GST-pi has the antimutagenesis and antitumor ability, and is related closely with the resistance of tumor to anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural localization of glutathione S-transferase-pi in human colorectal cancer cells

Guo

2000

WJG

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“…This detoxification ability plays a role in cellular defenses from environmental and oxidative stress. Moreover, overexpression of specific GSTs can also affect chemoresistance (Hamada et al, 1994;Byun et al, 2005), whereas polymorphisms that decrease GST activity are associated with a high risk of developing cancer (Balendiran et al, 2004). In the present study, cisplatin-mediated decrease in GST activity in liver (Fig.…”

Section: Discussionmentioning

confidence: 47%

Ascorbic Acid (Vitamin C)-Mediated Protection on Mutagenic Potentials of Cisplatin in Mice Bearing Ascites Dalton ’s Lymphoma

Amenla¹,

Prasad²

2016

Research J. of Mutagenesis

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Cisplatin is a potent anticancer drug which has been in use against a variety of cancers for a long time. The present study was carried out to assess the protective ability of ascorbic acid on cisplatin-induced mutagenic effects in tumor-bearing mice. The increase in the frequency of chromosomal aberrations, micronuclei and sperm abnormality were studied as markers of mutagenicity. Indicators of oxidative stress relatives like lipid peroxidation, reduced glutathione and the activities of enzymes such as catalase, glutathione-S-transferase and glutathione reductase were also studied to understand the possible mechanism(s) underlying this amelioration. Pre-treatment with ascorbic acid in combination group significantly reduced cisplatin-induced mutagenicity, markedly decreased lipid peroxidation along with increased level of glutathione and activities of antioxidant enzymes particularly in the liver of mice. The overall studies suggest that ascorbic acid with its antioxidant and free radical scavenging properties may play a part in its protective role in the abatement of cisplatin-induced mutagenesis and oxidative damage in the normal tissues of mice.

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Expression of Glutathione S-Transferase-π in Human Ovarian Cancer as an Indicator of Resistance to Chemotherapy

Cited by 91 publications

References 0 publications

Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?

Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?

Ultrastructural localization of glutathione S-transferase-pi in human colorectal cancer cells

Ascorbic Acid (Vitamin C)-Mediated Protection on Mutagenic Potentials of Cisplatin in Mice Bearing Ascites Dalton ’s Lymphoma

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