Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients

Sharif, Saima; Maqsood, Maha; Naz, Shagufta; Manzoor, Farkhanda; Jahan, Malik Shah; Farasat, Tasnim

doi:10.1615/critreveukaryotgeneexpr.2019025074

Cited by 5 publications

(4 citation statements)

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“…A study investigating the expression of glutathione Stransferases class theta 1 (GSTT1) in type 2 DR subjects reported that highly significant differences (P ≤ 0.05) were observed in GSST1 expression in DR patients compared to diabetic and control groups [38]. Our study did not confirm an association between GSTM1 gene polymorphism and other microangiopathic lesions in our diabetic patients.…”

Section: Discussioncontrasting

confidence: 91%

Evaluation of glutathione S-transferase polymorphism in Iranian patients with type 2 diabetic microangiopathy

Hashemi‐Soteh

Amiri

Rezaee

et al. 2020

Egypt J Med Hum Genet

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Background: Overproduction of reactive oxygen species as a result of hyperglycemia in diabetes mellitus leads to microvascular complications. Glutathione S-transferases play important detoxifying roles with antioxidant potentials. This study aimed to assess whether the glutathione S-transferase M1 and T1 genotypes were associated with type 2 diabetes mellitus microangiopathic complications in the Iranian population. Results: In this case-control study, the frequencies of null GSTM1 and GSTT1 genotypes were 4/72 (5.56%) and 12/ 72 (16.67%) respectively, in uncomplicated DM group. The frequencies of null GSTM1 and GSTT1 genotype in complicated DM group were 16/134 (11.94%) and 37/134 (27.61%), respectively. The proportion of GSTM1 null genotypes was higher in diabetic nephropathy compared to non-nephropathy (19.3% vs. 6.04 %, P = 0.006). At GSTT1 locus, patients with diabetic peripheral neuropathy had a higher frequency of deletion compared to those of without neuropathy (30.39% vs. 23.49%) (P = 0.02). Conclusion: Selective polymorphisms encoding GSTM1 and GSTT1genes may prove useful as genetic markers to recognize individuals with an increased trend in developing diabetic nephropathy and neuropathy, respectively. This will help better identify individuals at higher risk toward microvascular complications of type 2 diabetes due to genetic susceptibility.

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Section: Discussioncontrasting

confidence: 91%

Evaluation of glutathione S-transferase polymorphism in Iranian patients with type 2 diabetic microangiopathy

Hashemi‐Soteh

Amiri

Rezaee

et al. 2020

Egypt J Med Hum Genet

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“…This result was consistent with the only study in Chinese people conducted by Wang et al [14]. The GSTT1-null allele has been reported to be associated with both macrovascular and microvascular disease in T2DM patients, including diabetic nephropathy and retinopathy [20,26,39,40,41]. In recent studies, it was demonstrated that the deletion polymorphism of GSTT1 could increase the risk for diabetic retinopathy in the Caucasian population [28,42].…”

Section: Discussionsupporting

confidence: 90%

Influence of GSTT1 and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Retinopathy Risk in The Chinese Population: A Case Control Study

Geng

Zha²,

Zhou

et al. 2020

Preprint

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Background: Studies have revealed the association of glutathione S-transferases (GSTM1 and GSTT1) deletion (null) polymorphism with the risks of developing type 2 diabetes mellitus (T2DM) and its complications. The present study aimed to investigate the relationship between GSTT1/ GSTP1 gene polymorphisms and the risks of T2DM and diabetic retinopathy (DR) in a Chinese population.Methods: A total of 336 subjects with T2DM and a defined ophthalmologic status were recruited from the Second People’s Hospital of Yunnan Province between June 2014 and October 2016. Seventy-two age-matched healthy controls were also enrolled. Physical examinations and laboratory tests were performed. The frequencies of GSTT1 and GSTP1 genotypes in all participants were determined by PCR and PCR-restriction fragment length polymorphisms (PCR–RFLP), respectively.Results: Compared with healthy controls, the GSTT1-null genotype was significantly more common in diabetic patients with or without DR (all P < 0.05). However, the frequency of the GSTP1 genotype (AA, GA, GG) was comparable between the two groups. Furthermore, neither the GSTP1 nor GSTT1 genetic polymorphism was associated with the development of DR. In the present study, the risk of developing T2DM was significantly higher in subjects carrying the combined heterozygous GSTP1 (AG) and null GSTT1 genotypes (OR=0.40, 95% CI=0.21-0.74, P=0.02).Conclusions: The deletion of the GSTT1 genotype was associated with a higher risk of developing T2DM, whether alone or in combination with GSTP1, indicating that the null genotype of GSTT1 may serve as a potential biomarker for T2DM in the Chinese population, which is helpful for clinicians to make more effective risk-based decisions.

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“…Lentinan has been shown to act on reduced macrophages and inhibit oxidized macrophages. Oxidized macrophages produce reactive oxygen intermediates, tumor necrosis factor, and interleukin-6 (IL-6) [37]. Although the relationship between β-glucan in mushrooms and serum homocysteine concentration is unknown, a previous study that examined the relationship between several inflammatory biomarkers associated with atherosclerosis risk showed a significant positive association between IL-6 and blood homocysteine concentration [38].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women

Tajima,

Kubo,

Horiguchi

et al. 2023

Nutrients

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Homocysteine is a methionine metabolism intermediate and its increased blood levels are associated with a higher risk of noncommunicable diseases. Reportedly, blood homocysteine levels increase with inadequate folate, vitamin B6, and vitamin B12 intake; however, its relationship with dietary factors other than these three vitamins remains unknown. Thus, we investigated the relationship of homocysteine with other nutrient intake. We performed a dietary survey on 227 young women using a food record with approximate amounts for 7 consecutive days in conjunction with digital imaging. We collected early morning fasting blood samples the day after the dietary survey was completed and analyzed the serum homocysteine levels. We observed that the serum homocysteine concentrations were significantly negatively associated with soluble, insoluble, and total fiber intake. In addition, participants with high fruit and mushroom intake displayed lower serum homocysteine concentrations, suggesting dietary fiber involvement from these foods. However, we observed no serum homocysteine concentration-related association with cereals and vegetables (well-documented dietary fiber sources) or with fruits and mushrooms. In conclusion, fiber quality-related differences could thus be caused by different sources, including antioxidant components such as fruit polyphenols and mushroom antioxidant and anti-inflammatory factors.

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Expression of Gstt1 in Type 2 Diabetic Retinopathy Patients

Cited by 5 publications

References 0 publications

Evaluation of glutathione S-transferase polymorphism in Iranian patients with type 2 diabetic microangiopathy

Evaluation of glutathione S-transferase polymorphism in Iranian patients with type 2 diabetic microangiopathy

Influence of GSTT1 and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Retinopathy Risk in The Chinese Population: A Case Control Study

Relationship between Serum Homocysteine Concentration and Dietary Factors in Young Japanese Women

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