Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD

Liu, Weijing; Sun, Pengfei; Yan-ju, Zhou

doi:10.3892/etm.2018.7111

Cited by 15 publications

(17 citation statements)

References 20 publications

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“…Shandong First Medical University (Shandong Academy of Medical Sciences), 169 Great Wall Rd, Taian 271000, Shandong, China. 4 Zibo Bashan Wanjie Hospital, Zibo, Shandong, China.…”

Section: Resultsmentioning

confidence: 99%

“…Smoking, drinking, hypertension and diabetes are relative to the risk of CVD [2]. Recent studies reported that serum biomarkers such as blood glucose (GLU), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), Uric Acid (UA), thyroid-stimulating hormone (TSH), Homocysteine (Hcy) and other biomarkers were associated with the risk of CVD [2][3][4][5][6][7][8]. However, the results were inconsistent, and most of them focused only on one or several biomarkers, neglected the effect of multi-biomarker for the risk of CVD.…”

Section: Introductionmentioning

confidence: 99%

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Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Yao¹,

Hou

Liu

et al. 2020

BMC Cardiovasc Disord

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Background Previous studies focus on one or several serum biomarkers and the risk of cardiovascular disease (CVD). This study aims to investigate the association of multiple serum biomarkers and the risk of CVD and evaluate the dose-relationship between a single serum metabolite and CVD. Methods Our case-control study included 161 CVD and 160 non-CVD patients who had a physical examination in the same hospital. We used stratified analysis and cubic restricted analysis to investigate the dose-response relationship of individual serum biomarkers and the CVD incident. Moreover, to investigate serum biomarkers and CVD, we used elastic net regression and logistic regression to build a multi-biomarker model. Results In a single serum biomarker model, we found serum FT4, T4. GLU, CREA, TG and LDL-c were positively associated with CVD. In the male group, serum T4, GLU and LDL-c were positively associated with CVD; and serum TG was positively associated with CVD in the female group. When patients ≤63 years old, serum T4, GLU, CREA and TG were positively associated with CVD, and serum TG and LDL-c were positively associated with CVD when patients > 63 years old. Moreover, serum GLU had nonlinearity relationship with CVD and serum TG and LDL-c had linearity association with CVD. Furthermore, we used elastic regression selecting 5 serum biomarkers (GLU, FT4, TG, HDL-c, LDL-c) which were independently associated with CVD incident and built multi-biomarker model. And the multi-biomarker model had much better sensitivity than single biomarker model. Conclusion The multi-biomarker model had much higher sensitivity than a single biomarker model for the prediction of CVD. Serum FT4, TG and LDL-c were positively associated with the risk of CVD in single and multiple serum biomarkers models, and serum TG and LDL-c had linearity relationship with CVD.

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“…Shandong First Medical University (Shandong Academy of Medical Sciences), 169 Great Wall Rd, Taian 271000, Shandong, China. 4 Zibo Bashan Wanjie Hospital, Zibo, Shandong, China.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Yao¹,

Hou

Liu

et al. 2020

BMC Cardiovasc Disord

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“…The patients with ACS had higher levels of TC, TG, LDL-C and lower level of HDL-C than those in the control group in previous studies [ 24 , 25 ]. There is evidence indicating that TC, TG, LDL-C and HDL-C levels could be used as risk markers of cardiovascular disease with a strong correlation with coronary atherosclerosis [ 16 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 67%

“…Additionally, pathophysiological mechanism of insulin resistance, type 2 diabetes, and endothelial dysfunction occurs through extracellular signal-regulated kinase activity [7,22,23]. The patients with ACS had higher levels of TC, TG, LDL-C and lower level of HDL-C than those in the control group in previous studies [24,25]. There is evidence indicating that TC, TG, LDL-C and HDL-C levels could be used as risk markers of cardiovascular disease with a strong correlation with coronary atherosclerosis [16,26,27].…”

Section: Discussionmentioning

confidence: 94%

The correlation of retinol-binding protein-4 and lipoprotein combine index with the prevalence and diagnosis of acute coronary syndrome

Liu

Han

et al. 2020

Heart Vessels

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Retinol-binding protein-4 (RBP-4) along with the lipid profile plays crucial roles in Acute coronary syndrome (ACS). The study aimed to investigate the correlation of RBP-4, lipoprotein combine index (LCI), and RBP-4 + LCI with ACS. 163 ACS and 77 non-CAD in patients were consecutively enrolled in this study. The serum level of RBP-4 was measured via enzyme-linked immunosorbent assay. LCI was calculated using the formula: total cholesterol × triglyceride × low-density lipoprotein cholesterol/high-density lipoprotein cholesterol. RBP-4 ≥4 ng/ml, LCI ≥16 and LCI ≥16 + RBP-4 ≥4 ng/ml were new independent risk factors of ACS, and OR value of LCI ≥16 + RBP-4 ≥4 ng/ml was higher than that of RBP-4 and LCI combined (all p < 0.05). The AUC for LCI + RBP-4 was higher than that for LCI and RBP-4 individually. The risk of high LCI in 1 lesion vessel was greater than those of 2 or ≥3 lesion vessels (all p < 0.05). In 1 lesion vessel or ≥3 lesion vessels group, the risk associated with LCI and RBP-4 combined was higher than the risk of LCI or RBP-4 alone (all p < 0.05). The risk of hypertension, diabetes mellitus, smoking and history of MI increased with numbers of vessels lesion (all p < 0.05). Increase in RBP-4 and LCI values were found to be independent risk factors for ACS, and the risk of the combined rise in LCI and RBP-4 values was higher than LCI or RBP-4 alone. The combined tests of LCI and RBP-4 might be a potential diagnostic marker for ACS.

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“…In developing countries such as China, the rising momentum of CHD burden has not been effectively curbed [2]. Control of risk factors such as hypertension, diabetes, hyperlipidemia, obesity and smoking can reduce incidence and mortality rates of CHD [3]. The use of antiplatelet drugs, statins, renin angiote ns in aldosterone system blockers and β receptor blockers can also improve the prognosis of patients with CHD [4].…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Fish Oil in Preventing Coronary Heart Disease: A Systematic Review and Meta-Analysis

Wu¹,

Geng²,

Jiang³

et al. 2020

Preprint

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To evaluate the efficacy of fish oil for protection against coronary heart disease (CHD), we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating the use of fish oil for protection against CHD. We retrieved relevant articles published from January 1966 to January 2020 by searching the PubMed, EMBASE, Cochrane CENTRAL, and Web of Science databases. RCTs of fish oil in preventing CHD were selected. The study quality was evaluated using the Cochrane Risk of Bias tool with RevMan 5.3 software. The first selection involved 350 citations. After screening and evaluation of suitability, 19 RCTs adjusted for clustering were included in the meta-analysis. All selected manuscripts considered that fish oil was effective in preventing CHD, secondary outcome measures included angina, sepsis and death. Compared with the control group, fish oil may confer significant protection against CHD (odds ratio = 0.84; 95% confidence interval: 0.72–0.98). There was no significant difference in the incidence of secondary outcomes between the observation group and the control group (P > 0.05). The above results show that fish oil plays an important role in reducing CHD and cardiovascular events. However, because of the suboptimal quality of the studies included into the meta-analysis, these results do not justify adding fish oils systematically to the heavy pharmaceutical assortment already recommended in CHD patients.

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Expression of Hcy and blood lipid levels in serum of CHD patients and analysis of risk factors for CHD

Cited by 15 publications

References 20 publications

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

Associations of multiple serum biomarkers and the risk of cardiovascular disease in China

The correlation of retinol-binding protein-4 and lipoprotein combine index with the prevalence and diagnosis of acute coronary syndrome

The Efficacy of Fish Oil in Preventing Coronary Heart Disease: A Systematic Review and Meta-Analysis

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