Relationship between insulin resistance, adiponectin and C-reactive protein and vascular endothelial injury in diabetic patients with coronary heart disease (CHD) was investigated. Clinical data of 72 patients with diabetes mellitus diagnosed in Weifang People's Hospital (Weifang, China) from October 2015 to January 2017 were retrospectively analyzed. Thirty patients were combined with CHD and 42 patients were not. There were 43 males and 29 females. General information and clinical data including age, sex, duration of diabetes mellitus, biochemical indicators, fasting insulin levels, CRP, insulin resistance index, arterial lesions of coronary angiography and Gensini scores were collected. The levels of FINS, FPG, HOMA-R and CPR were significantly higher, and the level of ADPN was significantly lower in diabetes complicated with CHD group than that without CHD group (P<0.05). Incidence of single coronary artery disease and mild coronary lesion were significantly lower, and incidences of double and triple lesions were significantly higher in diabetes complicated with CHD group than that without CHD group (P<0.05). Gensini score was significantly higher in diabetes complicated with CHD group than that without CHD group (P<0.05); Analysis of the correlation showed that CRP (r=0.422, P=0.001) and insulin resistance index (r=0.828, P=0.001) were positively correlated with Gensini score, while the adiponectin level was negatively correlated with Gensini score (r= −0.719, P<0.001). Logistic regression analysis showed that FINS, ADPN, HOMA-R, CPR, duration of diabetes mellitus and BMI had independently predictive value for diabetes complicated with CHD (P<0.05). Serum adiponectin, insulin resistance and CPR levels are closely related to diabetes mellitus combined with coronary heart disease, and can affect the degree of vascular endothelial injury in coronary heart disease.

Expression of homocysteine (Hcy) and blood lipid levels in serum of atherosclerotic coronary heart disease (CHD) patients was investigated and the related risk factors were analyzed. A total of 148 CHD patients were selected as study group and another 120 healthy people attending Weifang People's Hospital for physical examination in the same period as control group. Hcy and blood lipid levels in serum were measured in the two groups, including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). At the same time, analysis of risk factors for CHD was performed. The levels of Hcy, TC, TG and LDL-C in patients in the study group were significantly higher than that in control group, while the HDL-C level was significantly lower than that in control group, and the differences were statistically significant (P<0.001). The difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between acute and old myocardial infarction and angina pectoris group (P<0.05), and the difference was statistically significant in the levels of Hcy, TC, TG and LDL-C between old and acute myocardial infarction group (P<0.05). Analysis of risk factors for the disease was performed using logistic regression. The results of univariate analysis showed that CHD was associated with Hcy, hyperlipidemia, smoking, hypertension and diabetes (P<0.05), but had no relationship with drinking and obesity (P>0.05). The results of multivariate analysis showed that Hcy, hyperlipidemia, hypertension and diabetes were independent risk factors for CHD, and the difference was statistically significant (P<0.05). The Hcy level increased and the HDL-C level decreased in serum of CHD patients. Hcy, hyperlipidemia, hypertension and diabetes are independent risk factors for CHD, which can provide practical basis for the diagnosis, treatment and prevention.