2014
DOI: 10.1152/ajpgi.00299.2013
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Expression of heat shock proteins 27 and 72 correlates with specific commensal microbes in different regions of porcine gastrointestinal tract

Abstract: The gastrointestinal (GI) tract of mammals is inhabited by trillions of microorganisms, resulting in exceedingly complex networking. The interaction between distinct bacterial species and the host immune system is essential in maintaining homeostasis in the gut ecosystem. For instance, the gut commensal microbiota dictates intestinal mucosa maturation and its abundant immune components, such as cytoprotective heat shock proteins (HSP). Here we examined physiological expression of HSP in the normal porcine GI t… Show more

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Cited by 24 publications
(27 citation statements)
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“…35,38,58,65 Thus, strong immunostaining of iHSP proteins is observed in villi of the small intestine and in upper-crypt epithelial cells in the colon, with virtually no staining along the crypts at either site. Of note, ileal Peyer's patches stained strongly for iHSPs in the pig, but the precise identity of the iHSP-containing cells was not disclosed.…”
Section: Regional Tissue and Cell Distribution Of Inducible Heat-shmentioning
confidence: 96%
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“…35,38,58,65 Thus, strong immunostaining of iHSP proteins is observed in villi of the small intestine and in upper-crypt epithelial cells in the colon, with virtually no staining along the crypts at either site. Of note, ileal Peyer's patches stained strongly for iHSPs in the pig, but the precise identity of the iHSP-containing cells was not disclosed.…”
Section: Regional Tissue and Cell Distribution Of Inducible Heat-shmentioning
confidence: 96%
“…70 Further links between the gut commensal microbiota and iHSPs in vivo were recently demonstrated in growing pigs. 65 Ileal HSP27 was found to correlate negatively with particular luminal bacteria (Lactobacillus reuteri and Enterobacteriaceae) ( Table 4). 65 Ileal iHSP correlated positively with lactic acid-producing bacteria and L. johnsonii.…”
Section: Inducible Heat-shock Proteins and The Gut Microbiota Gut Micmentioning
confidence: 99%
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