Expression of homeobox gene-GBX2 in human prostatic cancer cells

Gao, Allen C.; Isaacs, John T.

doi:10.1002/(sici)1097-0045(199612)29:6<395::aid-pros8>3.0.co;2-7

Cited by 16 publications

(4 citation statements)

References 15 publications

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“…nkx-3.1 null mice also develop epithelial hyperplasia and dysplasia in the anterior and dorsolateral lobes that increases in severity with age, suggesting that this homeobox gene may be a candidate tumor suppressor gene [23]. In contrast, the homeobox genes GBX1 and GBX2 have been found to be overexpressed in prostate cancer cell lines, and reduction of GBX 2 expression results in decreased clonogenic ability in vitro and tumorigenicity in vivo [6]. Together these data suggest that both gain and loss of function of certain homeobox genes may play a role in prostate cancer progression.…”

Section: Hoxb-13 Expression In Prostatementioning

confidence: 94%

“…Although their roles in pattern formation during early embryonic development have been studied extensively, their roles in later developmental events and tissue maintenance have received comparatively little attention. The importance of understanding their functions in differen-tiated cells is underscored by the recognition that deregulated expression of Hox and other classes of homeobox-containing genes have been implicated in oncogenic transformation of cultured cells and in tumors [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…Several members of the Hox family of homeobox genes have been found to be expressed in human prostate cell lines [6] and in mouse embryos in the region of the urogenital sinus that gives rise to pros- tate glands [10,11]. hoxd-13 has been shown to be expressed in the urogenital sinus during late gestation and in early postnatal mouse prostate glands, but is repressed at maturity [10].…”

Section: Introductionmentioning

confidence: 99%

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Androgen-independent expression ofhoxb-13 in the mouse prostate

et al. 1999

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BACKGROUND Hox genes encode transcriptional regulatory proteins that are largely responsible for establishing the body plan of all metazoan organisms. A subset of Hox genes is expressed during the period of organogenesis and into adulthood. hoxb‐13 is a recently‐described member of the Hox gene family that is expressed in the spinal cord, hindgut, and urogenital sinus during embryogenesis. METHODS Northern blot and in situ hybridization analyses of hoxb‐13 expression in adult mouse tissues were performed. RESULTS hoxb‐13 mRNA is restricted to the prostate gland and distal colon in adult animals. In situ hybridization of mouse prostate tissue demonstrated that hoxb‐13 is expressed in the epithelial cells of the ventral, dorsal, lateral, and anterior prostate lobes. Accumulation of hoxb‐13 mRNA is not diminished following castration. CONCLUSIONS These data demonstrate that hoxb‐13 expression is androgen‐independent in mouse prostate glands. The identification of hoxb‐13 as an androgen‐independent gene expressed in adult mouse prostate epithelial cells provides a new potential target for developing therapeutics to treat advanced prostate cancer. Prostate 41:203–207, 1999. © 1999 Wiley‐Liss, Inc.

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Section: Hoxb-13 Expression In Prostatementioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Androgen-independent expression ofhoxb-13 in the mouse prostate

et al. 1999

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“…Furthermore, nkx3.1 maps to a prostate cancer hot spot [18]. GBX2, another non-class I homeobox gene, may be involved in determining the aggressive ability of human prostate cancer cells [19], and its overexpression is an important requirement for the clonogenic ability and tumorigenicity of human prostate cancer cell lines [20]. More recently, hoxb-13 has been identi®ed as an androgen-independent gene expressed in adult mouse epithelial cell [21].…”

Section: Introductionmentioning

confidence: 99%