Expression of HSP70 Heat-Shock Proteins under Oxidative Stress

Курашова, Н. А.; Мадаева, Ирина; Колесникова, Л. И.

doi:10.1134/s2079057020010099

Cited by 36 publications

(24 citation statements)

References 42 publications

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“…Eukaryotic and prokaryotic cells can produce heat shock proteins (HSPs) in response to different insults [71]. These proteins were discovered in 1962 by Ritossa [75], and may be present both inside the cell and on the cell membrane [76]. In general, HSPs exhibit different behaviors in different situations, and so some of these proteins can be produced constructively and effectively under natural conditions.…”

Section: Redox-sensitive Heat Shock Proteins (Hsps) Signaling Pathwaymentioning

confidence: 99%

“…However, when these proteins are overproduced under stressful conditions such as ischemia, exercise, oxidative stress, heat, hypoxia, high temperature, inflammation, free radicals and ROS, and acute or chronic diseases, they lead to denaturation of proteins. On the one hand, immune reactions and tumor formation play an important role in the development of OS associated with aging [75][76][77]. On the other hand, in such stressful situations, HSPs may protect the body's cells through various processes such as the initiation of protein folding, repair, refolding of misfolded peptides, and possible degradation of irreparable proteins.…”

Section: Redox-sensitive Heat Shock Proteins (Hsps) Signaling Pathwaymentioning

confidence: 99%

“…Insufficient or excessive antioxidants are one of the important factors that can modulate the activity and subsequent synthesis of HSPs. In fact, antioxidants known as ROS neutralizers are able to inhibit HSPs genes [76].…”

Section: Redox-sensitive Heat Shock Proteins (Hsps) Signaling Pathwaymentioning

confidence: 99%

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A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Taherkhani

Castell

2020

Antioxidants

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Excessive release of inflammatory cytokines and oxidative stress (OS) are triggering factors in the onset of chronic diseases. One of the factors that can ensure health in humans is regular physical activity. This type of activity can enhance immune function and dramatically prevent the spread of the cytokine response and OS. However, if physical activity is done intensely at irregular intervals, it is not only unhealthy but can also lead to muscle damage, OS, and inflammation. In this review, the response of cytokines and OS to exercise is described. In addition, it is focused predominantly on the role of reactive oxygen and nitrogen species (RONS) generated from muscle metabolism and damage during exercise and on the modulatory effects of antioxidant supplements. Furthermore, the influence of factors such as age, sex, and type of exercise protocol (volume, duration, and intensity of training) is analyzed. The effect of antioxidant supplements on improving OS and inflammatory cytokines is somewhat ambiguous. More research is needed to understand this issue, considering in greater detail factors such as level of training, health status, age, sex, disease, and type of exercise protocol.

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Section: Redox-sensitive Heat Shock Proteins (Hsps) Signaling Pathwaymentioning

confidence: 99%

Section: Redox-sensitive Heat Shock Proteins (Hsps) Signaling Pathwaymentioning

confidence: 99%

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A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Taherkhani

Castell

2020

Antioxidants

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“…При воздействии «стрессорного» фактора внутриклеточное содержание HSP70 (белок теплового шока с молекулярной массой 70 кДа) может увеличиваться в десятки раз и составлять до 5% от содержания всех клеточных белков [3]. Имеются данные о том, что к экспрессии HSP70 способен широкий спектр клеток, в том числе гепатоциты, лимфоциты и макрофаги [4]. Внутриклеточный HSP70 не только опосредует шаперон-цитопротекторные функции, но также может блокировать избыточный апоптоз [5].…”

Section: ââåäåíèåunclassified

Immunopathological mechanisms of toxic damage to the liver, thymus and spleen

Shafigullina¹,

Данилова²

2020

Immunopathol Allergol Infectol

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Objective: to establish the features of the immune response in the early stages of diffuse toxic damage. Materials and methods. Diffuse toxic liver damage of male Wistar rats was caused by a single intraperitoneal injection of an oil solution of carbon tetrachloride (CCl4) at a dose of 50 mg/100 g. Animals were carried out from the experiment on days 3, 7 and 14. The study included hematological and histological analysis, immunohistochemical (IHC) staining of liver, thymus and spleen tissues, quantitative evaluation of CD3+, CD45RA+ (T-and B-lymphocytes), F4/80+ (macrophages), and HSP70+-cells. Results. CCl4 administration has been shown to cause structural disorders of liver, thymus, and spleen tissue. In the early stages, there is an increase in CD3+-cells in the liver and spleen, while CD45RA+-cells predominating in the thymus. On the 3rd day after CCl4 administration, the number of F4/80+-cells in the liver increases by 56.7%, in the thymus and spleen by 21% and 19.3%, respectively, there is also an increase in the number of HSP70+-cells roughly 2 times in the liver and thymus, and by 7 times in the spleen. Conclusion. Hepatotropic poison CCl4 causes damage not only the liver but the organs of immunopoesis. In the early stages of exposure to the toxicant the predominant population is T-lymphocytes (CD3+-cells) in the liver and spleen, and B – lymphocytes (CD45RA+-cells) in the thymus. In all the studied organs, the number of macrophages increases on the 3rd day of the experiment, and significantly decreases at the later term. This fact indicates that macrophages act as a target of toxic effects. The increase in the number of HSP70+-cells in the liver, thymus, and spleen in response to toxic damage is likely aimed at triggering the repair or elimination of denatured proteins that are toxic to the cell.

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“…(2,4) Another factor affecting the decrease in male fertility is the hyperproduction of ROS. (11)(12)(13) ROS damage the sperm membrane, which leads to a decrease in sperm quality. (10,12) At the stationary level, lipid peroxidation processes are maintained due to the work of the AOS, which includes enzymatic and non-enzymatic links.…”

Section: Introductionmentioning

confidence: 99%

Sperm Quality and Oxidative-Antioxidant Profile in Men Living in Different Regions of Siberia

Курашова¹,

Dashiev²,

Колесникова³

2020

IJBM

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Background: The aim of this study was to assess the sperm quality and oxidative-antioxidant profile in men living in different regions of Siberia Materials and Methods: The study involved 125 men of reproductive age: 40 men (mean age of 24.8 years) living in Ulan-Ude, 35 men (mean age of 24.1 years) in Irkutsk, and 50 men (mean age of 24.6 years) in Novosibirsk. All men belonged to the Caucasian race and were physically healthy. Methods of standard clinical examination of fertile and infertile men included: an ultrasonic scan of scrotum and prostate, macroscopic and microscopic examination of ejaculate, and biochemical analysis. The semen analysis was performed in accordance with the WHO recommendations (2010). The study of sperm quality included measuring the volume and pH of the ejaculate, the concentration of spermatozoa, the proportion of motile sperm of categories A and B, and lipid peroxidation-antioxidant activity products. Of the participants in the study, the group of somatically healthy men living in Irkutsk had the highest sperm count (mln per ml): 1.5 times more than men in Novosibirsk and 1.3 times more than men in Ulan-Ude. At the same time, in the group of men in Irkutsk, a significant increase in the concentration of α-tocopherol was revealed: 1.6 times more than the men in Ulan-Ude and 1.8 times more than the men in Novosibirsk. Conclusion: The conducted studies of the quality of ejaculate and the characteristics of LPO processes in men from different cities of Siberia show that place of residence and ecological-geographical position are not the main reasons determining reproductive dysfunction, but can be important factors affecting the functioning of the reproductive system and determining the heterogeneity of male infertility in conditions of anthropogenic pressure.

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Expression of HSP70 Heat-Shock Proteins under Oxidative Stress

Cited by 36 publications

References 42 publications

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

A Short Overview of Changes in Inflammatory Cytokines and Oxidative Stress in Response to Physical Activity and Antioxidant Supplementation

Immunopathological mechanisms of toxic damage to the liver, thymus and spleen

Sperm Quality and Oxidative-Antioxidant Profile in Men Living in Different Regions of Siberia

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