Expression of HSP70 in Mytilus californianus following exposure to caffeine

Rey, Zoe Rodriguez del; Granek, Elise F.; Buckley, Bradley A.

doi:10.1007/s10646-011-0649-6

Cited by 24 publications

(13 citation statements)

References 34 publications

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“…Recent studies using environmentally relevant concentrations have shown chronic caffeine exposure may be deleterious. Caffeine treatment leads to upregulation of Hsp-70 in the mussel Mytilus californianus [8] and to destabilization of lysosomal membranes in the clam Ruditapes philippinarum and the crab Carcinus maenas [9, 10], two indicators of cellular stress. Increasing our knowledge regarding how caffeine affects aquatic organisms, especially chronic exposure, is important for assessing the risks associated with caffeine contamination of the environment.…”

mentioning

confidence: 99%

The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms

Mustard

2013

Cell. Mol. Life Sci.

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A number of recent studies from as diverse fields as plant-pollinator interactions, analyses of caffeine as an environmental pollutant, and the ability of caffeine to provide protection against neurodegenerative diseases have generated interest in understanding the actions of caffeine in invertebrates. This review summarizes what is currently known about the effects of caffeine on behavior and its molecular mechanisms in invertebrates. Caffeine appears to have similar effects on locomotion and sleep in both invertebrates and mammals. Furthermore, as in mammals, caffeine appears to have complex effects on learning and memory. However, the underlying mechanisms for these effects may differ between invertebrates and vertebrates. While caffeine’s ability to cause release of intracellular calcium stores via ryanodine receptors and its actions as a phosphodiesterase inhibitor have been clearly established in invertebrates, its ability to interact with invertebrate adenosine receptors remains an important open question. Initial studies in insects and mollusks suggest an interaction between caffeine and the dopamine signaling pathway; more work needs to be done to understand the mechanisms by which caffeine influences signaling via biogenic amines. As of yet, little is known about whether other actions of caffeine in vertebrates, such as its effects on GABAA and glycine receptors, are conserved. Furthermore, the pharmacokinetics of caffeine remains to be elucidated. Overall behavioral responses to caffeine appear to be conserved amongst organisms; however, we are just beginning to understand the mechanisms underlying its effects across animal phyla.

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confidence: 99%

The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms

Mustard

2013

Cell. Mol. Life Sci.

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“…After 14 days of exposure to caffeine in the range of 0.1-50 µg/L, significant detrimental effects were observed in the clam Ruditapes philippinarum, with a dose-dependent reduction in hemocyte lysosomal membrane stability [51]. Values of biomarkers of oxidative stress and biotrasformation phase I and II were significantly higher in digestive glands, mostly at the highest caffeine concentrations tested.…”

Section: Discussionmentioning

confidence: 98%

“…Literature about caffeine toxicity in non-target aquatic organisms is limited. As for bivalves, the sub-lethal cellular toxicity of environmentally relevant concentrations of caffeine was investigated in the mussel Mytilus californianus [51]. In that study, Hsp70 concentrations in the gill and mantle tissues of mussels exposed to 0.05, 0.2, and 0.5 µg/L of caffeine for 10, 20, and 30 days were compared to basal levels of the control mussels.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Decreased pH and Caffeine Affects Hemocyte Parameters in the Mussel Mytilus galloprovincialis

Munari

Matozzo

Benetello

et al. 2020

JMSE

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Combined effects of reduced pH, as predicted under climate change scenarios, and the most popular and widely used stimulant caffeine were assessed in hemocyte parameters of the mussel Mytilus galloprovincialis, being hemocytes involved in immune defense. Bivalves were exposed for one week to natural pH (8.1) and two reduced pH values (pH −0.4 units and pH −0.7 units). Exposure continued for additional two weeks, both in the absence and in the presence of environmentally relevant concentrations of caffeine (0.05 and 0.5 µg/L). Hemocyte parameters (total hemocyte count, hemocyte volume and diameter, neutral red uptake and hemocyte proliferation) were measured after 7 days of exposure to pH only, and after 14 (T1) and 21 (T2) days of exposure to the various pH*caffeine combinations. At all sampling times, pH significantly affected all the biological variables considered, whereas caffeine exhibited a significant influence at T2 only. Among the various hemocyte parameters, caffeine caused a significant increase in total hemocyte count at T2, and in hemocyte volume and diameter at both T1 and T2, when a significant interaction between pH and caffeine was also found. Overall, results demonstrated that hemocyte functionality was strongly influenced by the experimental conditions tested. Further studies are needed to assess combined effects of climate changes and emerging contaminants on bivalve immune system when challenged with environmental pathogens.

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“…In addition to their role as indicators of human activity, PPCPs can also be toxicants, disrupting biological and ecological processes , with physiological, developmental, population, and ecosystem effects . In particular, antibiotics, such as ampicillin, erythromycin, and tetracycline, have been well documented to introduce antibiotic resistance following exposure.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 Once in the aquatic environment, PPCPs may sorb to organic matter, 18 degrade through physicochemical processes, 19 bioaccumulate and biomagnify within a food web, 20 or be metabolized by the organism itself. 21 In addition to their role as indicators of human activity, PPCPs can also be toxicants, disrupting biological and ecological processes 22,23 with physiological, 24 developmental, 25 population, 18 and ecosystem effects. 26 In particular, antibiotics, such as ampicillin, 27 erythromycin, 28 and tetracycline, 29 have been well documented to introduce antibiotic resistance following exposure.…”

Section: Introductionmentioning

confidence: 99%

An Evidence Synthesis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environment: Imbalances among Compounds, Sewage Treatment Techniques, and Ecosystem Types

Meyer

Powers

Hampton

2019

Environ. Sci. Technol.

160

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Pharmaceuticals and personal care products (PPCPs) garner increasing attention globally for both their usefulness as indicators of human waste and their potency as emerging organic toxicants. Three decades of rapid increase in PPCP study combined with an increasing number of PPCPs on the global market have created an opportunity (1) to review trends in diversity of compounds, sewage treatment techniques (STTs), and ecosystems investigated as well as (2) to identify knowledge gaps in the literature. We conducted a quantitative evidence synthesis of 6517 abstracts from primary articles in the environmental PPCP literature by examining relative abundance of specific PPCP classes, STTs, and ecosystem types. Our results demonstrate that non-prescription drugs and antibiotics dominated PPCP abstracts, appearing in 51% and 39% of reviewed abstracts, respectively, in comparison to hormones (18%), prescription drugs (18%), fragrances (0.3%), and antioxidants (0.0%), which can all elicit physiological and ecological responses even at low concentrations. References to centralized STTs (e.g., activated sludge, 37%) were more frequent than decentralized STTs (e.g., septic, 2%), despite decentralized STTs being common and frequently high impact sources of sewage pollution worldwide. Freshwater lotic systems (63%) were more prevalent than freshwater lentic (24%) and terrestrial (20%) systems. This discrepancy is notable because the longer residence times of lentic and terrestrial systems may enable PPCPs to concentrate and thus increase risk of biological consequences. These results highlight distinct opportunities to address knowledge gaps in the environmental PPCP literature, including underrepresented compounds (e.g., fragrances), sewage treatment techniques (e.g., septic systems), and ecosystem types (e.g., lakes).

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Expression of HSP70 in Mytilus californianus following exposure to caffeine

Cited by 24 publications

References 34 publications

The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms

The buzz on caffeine in invertebrates: effects on behavior and molecular mechanisms

Exposure to Decreased pH and Caffeine Affects Hemocyte Parameters in the Mussel Mytilus galloprovincialis

An Evidence Synthesis of Pharmaceuticals and Personal Care Products (PPCPs) in the Environment: Imbalances among Compounds, Sewage Treatment Techniques, and Ecosystem Types

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