Expression of human ABCB5 confers resistance to taxanes and anthracyclines

Kawanobe, Takaaki; Kogure, Sosuke; Nakamura, Sachiyo; Sato, Mai; Katayama, Kazuhiro; Mitsuhashi, Junko; Noguchi, Kohji; Sugimoto, Yoshikazu

doi:10.1016/j.bbrc.2012.01.090

Cited by 52 publications

(44 citation statements)

References 22 publications

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“…This transporter also participates in ATP-dependent transmembrane transport of structurally diverse molecules (Chen et al, 2005) and confers resistance to taxanes and anthracyclines (Frank et al, 2005;Kawanobe et al, 2012). T. foenum-graecum and A. maritima inhibited growth of ABCB5-transfected and non-transfected cells with similar efficacy.…”

Section: Discussionmentioning

confidence: 87%

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Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

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Abdelgadir

Sugimoto

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 87%

“…Cells were provided by Professor Y. Sugimoto (Division of Chemotherapy, Faculty of Pharmacy, Keio University, Tokyo, Japan). The generation and maintenance of HEK293 cells transfected with a cDNA for ABCB5 has been reported (Kawanobe et al, 2012). All cell lines have been tested to be mycoplasma-free.…”

Section: Human Multidrug Resistance Cancer Cell Linesmentioning

confidence: 99%

Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

Saeed

Abdelgadir

Sugimoto

et al. 2015

Journal of Ethnopharmacology

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“…Later studies revealed additional ABCB transporters as MDR proteins. Besides xenobiotic extrusion (ABCB1, 5, 8) [72]–[74], ABCB members are also known in human biology for the translocation, for example, of phosphatidylcholine (ABCB4) [75], bile acids (ABCB11) [76], peptides (TAP1:TAP2 (antigen processing in the adaptive immune system), TAPL, mitochondrial ABCB10) [77], metabolites of the heme synthetic pathway (ABCB6) [78], or iron (mitochondrial ABCB7 and 8) [79]–[82]. In insects, several examples suggest the involvement of P-glycoproteins in the resistance to insecticides used for crop protection [23], [24], [83]–[91].…”

Section: Resultsmentioning

confidence: 99%

Tissue-Specific Transcript Profiling for ABC Transporters in the Sequestering Larvae of the Phytophagous Leaf Beetle Chrysomela populi

et al. 2014

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BackgroundInsects evolved ingenious adaptations to use extraordinary food sources. Particularly, the diet of herbivores enriched with noxious plant secondary metabolites requires detoxification mechanisms. Sequestration, which involves the uptake, transfer, and concentration of occasionally modified phytochemicals into specialized tissues or hemolymph, is one of the most successful detoxification strategies found in most insect orders. Due to the ability of ATP-binding cassette (ABC) carriers to transport a wide range of molecules including phytochemicals and xenobiotics, it is highly likely that they play a role in this sequestration process. To shed light on the role of ABC proteins in sequestration, we describe an inventory of putative ABC transporters in various tissues in the sequestering juvenile poplar leaf beetle, Chrysomela populi.ResultsIn the transcriptome of C. populi, we predicted 65 ABC transporters. To link the proteins with a possible function, we performed comparative phylogenetic analyses with ABC transporters of other insects and of humans. While tissue-specific profiling of each ABC transporter subfamily suggests that ABCB, C and G influence the plant metabolite absorption in the gut, ABCC with 14 members is the preferred subfamily responsible for the excretion of these metabolites via Malpighian tubules. Moreover, salicin, which is sequestered from poplar plants, is translocated into the defensive glands for further deterrent production. In these glands and among all identified ABC transporters, an exceptionally high transcript level was observed only for Cpabc35 (Cpmrp). RNAi revealed the deficiency of other ABC pumps to compensate the function of CpABC35, demonstrating its key role during sequestration.ConclusionWe provide the first comprehensive phylogenetic study of the ABC family in a phytophagous beetle species. RNA-seq data from different larval tissues propose the importance of ABC pumps to achieve a homeostasis of plant-derived compounds and offer a basis for future analyses of their physiological function in sequestration processes.

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“…As a multi-drug resistance transporter, ABCB5 has the ability to regulate passage of drugs into the cell, and it induces resistance to melanoma treatment by the direct efflux of multiple chemotherapy agents. [86][87][88] Chemoresistance inferred by ABCB5 has been identified in other cancers, namely liver cancer and hepatocellular cancer. [89][90][91] A possible role has also been proposed in oral SCC and leukaemia, and it is overexpressed in almost a third of sporadic oesophageal cancer.…”

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confidence: 99%

“…There may also be a link with chronic lymphocytic leukaemia (CLL), which has somatic mutations in POT1 at relatively high frequency, the majority of which affect the OB folds, a finding that is in keeping with alterations detected in the recent melanoma studies. 38,39,87,88 One POT1 mutation carrier had a history of both melanoma and CLL, and it is possible that a variant exists that could affect a portion of the OB fold domain that is relevant to the development of both melanoma and CLL. 38 Additionally, POT1 has recently been implicated in the development of glioma.…”

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confidence: 99%

Familial melanoma risk genes in Queensland

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Melanoma 'risk' is multifaceted, with genetic, phenotypic, and environmental factors all contributing to melanoma predisposition. Although the majority of melanoma is attributable to random acquired mutations in melanocytes, a positive family history is associated with an increased risk of developing the disease, and the presence of heritable germline variants is an important component of melanoma susceptibility for some families. Mutation in one of the known high penetrance melanoma predisposition genes, comprising CDKN2A, CDK4, BAP1, POT1, ACD, TERF2IP, and TERT, underpins melanoma risk for approximately half of all high-density familial clustering of melanoma. However, the underlying genetic basis of disease remains unexplained for many families.It is likely that a polygenic component to melanoma predisposition accounts for the remainder of families, where overall susceptibility is influenced by combinations of low to moderate risk polymorphisms, rare high penetrance germline mutations, and modulation of risk by environmental and genetic factors. Although no single presently known germline alteration guarantees disease development, the main impact of predisposition genes is the elevation of baseline melanoma risk.For an individual with existing genetic susceptibility, it is likely that fewer sporadic mutations are required to accumulate before a critical level for oncogenesis is reached. Beyond conferring risk of cutaneous melanoma, some 'melanoma' predisposition genes have been linked to diverse cancer phenotypes. Familial risk has been proposed as a shared feature of many cancers, and clustering of additional cancers in melanoma families has been observed at rates greater than expected by chance.In a cohort of 178 'intermediate risk' melanoma families, cancer development was assessed over a 33 year period, and identified significantly more than expected bladder cancer, lymphoid leukaemia, and myeloma. Further to population level cancer risk, it is proposed that some cancer dense families carry known and possibly as-yet-unidentified melanoma predisposition genes.Eight families with high melanoma case density and eleven individuals with three or more invasive cancer types including melanoma were selected for further follow up with whole exome or whole genome sequencing. Multiple damaging variants in cancer-associated genes were identified, supporting a polygenic basis for melanoma susceptibility. Given the diversity of genetic variants and other cancer types in the cohort, it is possible that some cancer-associated genes identified here also have pleiotropic effects in predisposing to melanoma.iii

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Expression of human ABCB5 confers resistance to taxanes and anthracyclines

Cited by 52 publications

References 22 publications

Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells

Tissue-Specific Transcript Profiling for ABC Transporters in the Sequestering Larvae of the Phytophagous Leaf Beetle Chrysomela populi

Familial melanoma risk genes in Queensland

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