Expression of human leukocyte antigen‐G and its correlation with interleukin‐10 expression in cervical carcinoma

Abstract

HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.

Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix

“…18 Several studies have demonstrated that cervical cancer tissue expressed HLA-G and that its expression correlates with tumor progression. [5][6][7][8]10 In this report, the wildtype HLA-G*01:01:01 allele conferred protection against invasive cancer, whereas variant HLA-G*01:01:02, -G*01:06 and -G*3 0 UTR 14-bp insertion alleles increased cervical cancer risk. The HLA-G*01:01:02 and -G*01:06 alleles both have a synonymous substitution (Proline) at codon 57.…”

“…3,4 However, the link between HLA-G and cervical cancer has been inconsistent and contradictory in the published reports. For instance, HLA-G expression in cervical cancer tissue has been found to be increased, [5][6][7] reduced, 8 or absent. 9,10 HLA-G expression has correlated positively, 6,7 negatively, 5,10 or not at all 11 with cervical disease progression.…”

The paradox of IL-10-mediated modulation in cervical cancer

“…Results of a previous study demonstrated that human leukocyte antigen-G (HLA-G) and IL-10 mRNA and protein expression in cervical cancer tissues were significantly increased (45), suggesting that HLA-G and IL-10 may play an important role in cervical cancer progression. IL-10 contributes to the impairment of the anti-tumor immune response, either by downregulating human leukocyte antigen Class I expression or by increasing HLA-G expression in human trophoblasts and monocytes (46,47) and certain cancer models, such as lung cancer (48).…”

“…HLA-G is known to inhibit the cytotoxic activity of T lymphocytes and natural killer (NK) cells (49,50), which is associated with cancer development and immune tolerance. High HLA-G mRNA expression may be correlated with early carcinogenesis, since it was associated with early-stage cervical cancer (45). It was demonstrated that HLA-G expression was progressively higher in patients with CIN 1 to CIN 2/3 and was the highest in patients with cervical cancer, suggesting that HLA-G expression in cervical lesions may be associated with carcinogenesis, HPV infection and host immune response (51).…”

In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity

“…For example, IL-10 can contribute by increasing HLA-G expression on HLA class Ideficient cells to escape from NK-mediated lysis through interactions with killer inhibitory receptors on NK cells [48,49]. In CeCa lesions, the expression of both HLA-G and IL-10 associated with HPV infection might play an important role in CeCa progression [50,51]. In fact, it has been recently reported that in tissue samples from biopsies derived from patients with CeCa and with loss or downregulation of HLA class I expression, most of the HLA-G-positive cases (87.5%) exhibited upregulation of the IL-10 [52].…”