2008
DOI: 10.1042/bst0360590
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Expression of human snRNA genes from beginning to end

Abstract: In addition to protein-coding genes, mammalian pol II (RNA polymerase II) transcribes independent genes for some non-coding RNAs, including the spliceosomal U1 and U2 snRNAs (small nuclear RNAs). snRNA genes differ from protein-coding genes in several key respects and some of the mechanisms involved in expression are gene-type-specific. For example, snRNA gene promoters contain an essential PSE (proximal sequence element) unique to these genes, the RNA-encoding regions contain no introns, elongation of transcr… Show more

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Cited by 98 publications
(101 citation statements)
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“…Other major RNAPII transcribed genes producing transcripts <500 nt are snRNA loci (U1, U2, U4, U5, U11, U12, and U4atac) (Montzka and Steitz 1988;Jawdekar and Henry 2008) and loci producing the independently transcribed and capped snoRNAs (U3, U8, and U13). These genes also have specialized 39 end processing/ transcription termination systems (Kim et al 2006;Egloff et al 2008).…”
Section: Short Genes Use Pa Site-independent Terminatorsmentioning
confidence: 99%
“…Other major RNAPII transcribed genes producing transcripts <500 nt are snRNA loci (U1, U2, U4, U5, U11, U12, and U4atac) (Montzka and Steitz 1988;Jawdekar and Henry 2008) and loci producing the independently transcribed and capped snoRNAs (U3, U8, and U13). These genes also have specialized 39 end processing/ transcription termination systems (Kim et al 2006;Egloff et al 2008).…”
Section: Short Genes Use Pa Site-independent Terminatorsmentioning
confidence: 99%
“…We therefore constructed a reporter gene that relies on a promoter derived from the Drosophila U7 snRNA gene. snRNA genes associate with a distinct set of transcriptional factors, and primary transcripts generated from these genes (pre-snRNAs) are cleaved at the 3 ′ end by a distinct machinery termed Integrator that shares no common components with the two types of 3 ′ -end processing machineries operating on premRNAs (Baillat et al 2005;Egloff et al 2008;Ezzeddine et al 2011).…”
Section: Components Of the Hcc Essential Formentioning
confidence: 99%
“…These include the multisubunit transcription factor PTF/PBP/SNAPc (PSEbinding transcription factor/PSE-binding protein/snRNA-activating protein complex), which recognizes the PSE element located ;50 bp upstream of the transcription start site, and pol II phosphorylated on serine 7 (Ser7) of the carboxy-terminal domain (CTD) heptapeptide (Egloff et al 2008). In addition, we used antibodies to pol II and acetylated H3 core histone proteins, which are primarily associated with promoter regions of actively transcribing genes (Shahbazian and Grunstein 2007).…”
Section: U1 Snrna Class I Pseudogenes Are Transcriptionally Active Inmentioning
confidence: 99%