Expression of ICAM-1 on conjunctival epithelium and ECP in tears and serum from children with allergic conjunctivitis

Atopy and serum eosinophil cationic protein in 110 white children with vernal keratoconjunctivitis: differences between tarsal and limbal forms

“…In seasonal allergic conjunctivitis (SAC) mast cells but not eosinophils were recruited in ocular tissues [18], and s‐ECP levels were not higher than in controls [19], showing lack of serum markers of eosinophil involvement in SAC.…”

DS‐70, a novel and potent α4 integrin antagonist, is an effective treatment for experimental allergic conjunctivitis in guinea pigs

“…The early phase reaction leads to a late phase after 6–12 h that is sustained by T‐cell‐dependent processes through the production of cytokines and chemokines that mediate the recruitment and conjunctival infiltration of eosinophils and other immune cells (Choi and Bielory, ). This latter event requires the interaction between leukocyte surface‐adhesion receptors, such as integrins and selectins, and adhesion molecules expressed on the conjunctival endothelium, such as intercellular adhesion molecule‐1 (ICAM‐1) (Oh et al, ) and vascular cell adhesion molecule‐1 (VCAM‐1) (Baiula et al, ). Increased levels of cell adhesion molecules on the microvasculature and factors that regulate these molecules may perpetuate inflammation in allergic conjunctivitis (Okada et al, ).…”

Tear and Serum Eosinophil Cationic Protein Levels in Seasonal Allergic Conjunctivitis

“…Eosinophil cationic protein (ECP) is a highly cationic protein that comprises 30% of the eosinophil granule matrix (11). The degree of local involvement of eosinophils was evaluated by ECP measurements in various biologic fluids such as tears and nasal and bronchoalveolar lavage fluids and was reported to be increased in respective allergic diseases (12)(13)(14)(15). The presence of ECP in biological fluids and tissues is now considered as a specific marker for eosinophil activation (16)(17)(18)(19).…”