Expression of inflammatory biomarkers from cultured sebocytes was influenced by treatment with vitamin D

Lee, Weon Ju; Choi, Yoon Hyuk; Sohn, Mi Yeung; Lee, Seok Jong; Kim, Do Won

doi:10.4103/0019-5154.113959

Cited by 50 publications

(46 citation statements)

References 21 publications

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“…Isotretinoin acts on all mentioned processes in acne pathogenesis. It inhibits the development of Th17 cells and IL‐17 production, providing a therapeutic application of isotretinoin for the treatment of acne and other Th17‐mediated skin disease …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has antioxidant and anticomedogenic properties. So, a vitamin D deficiency may contribute in the pathogenesis of acne vulgaris …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has anticomedogenic and antioxidant effect. So, a vitamin D deficiency may facilitate the pathogenesis of acne …”

Section: Introductionmentioning

confidence: 99%

“…So, a vitamin D deficiency may facilitate the pathogenesis of acne. 15 In vitro studies identified vitamin D receptors in human sebocytes. 16 Vitamin D has been found to modulate lipid and cytokine production which suggest its possible role in acne pathophysiology.…”

mentioning

confidence: 99%

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Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

El‐Hamd

Taieb

Ibrahim³

et al. 2018

J of Cosmetic Dermatology

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Section: Discussionmentioning

confidence: 99%

“…Moreover, it has antioxidant and anticomedogenic properties. So, a vitamin D deficiency may contribute in the pathogenesis of acne vulgaris …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has anticomedogenic and antioxidant effect. So, a vitamin D deficiency may facilitate the pathogenesis of acne …”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

El‐Hamd

Taieb

Ibrahim³

et al. 2018

J of Cosmetic Dermatology

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“…Recently it has been shown in various studies that vitamin D does influence the expression of these cytokines thus proving beneficial in acne. 22 …”

Section: Vitamin D Uses In Dermatological Conditionsmentioning

confidence: 99%

Vitamin D and Its Role in Dermatology: A Review of Literature

Sharma¹,

Abrol²,

Badgal³

et al. 2015

jemds

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Vitamin D is a fat-soluble steroid hormone that is crucial for human health. Since long the role of epidermal keratinocytes in the UVB-induced photochemical conversion of 7-dehydrocholesterol to vitamin D3 is known, and also for the enzymatically controlled hydroxylation of the photolysis product. This whole process results in the formation of the biologically active final product 1, 25-(OH)2 D3 (Calcitriol). Moreover recently various research articles have shown benefits of calcitriol and various other vitamin D analogues having a therapeutic role in various dermatologic conditions like psoriasis, atopic dermatitis, acne, vitiligo owing to its anti-inflammatory, antiproliferative action. The present review shows a summary of role of vitamin D in dermatologic perspective. KEYWORDS: Vitamin D, calcitriol, anti-inflammatory, anti-proliferative. INTRODUCTION:Vitamin D is a fat-soluble prohormone and was identified after the discovery of the anti-rachitic effect of cod liver oil somewhere in the early part of the 20 th century. This vitamin which was found in cod liver oil was assigned as "vitamin D" following Vitamin A, B and C. 1 Vitamin D has two major biologically inert precursors, vitamin D3 (Cholecalciferol) and vitamin D2 (Ergocalciferol). 2,3 Out of these precursors, vitamin D3 is formed from 7-dehydrocholesterol present in the skin, which following exposure to solar ultraviolet B (UVB, 290-320 nm), is converted to previtamin D3. Previtamin D3 is immediately converted to vitamin D in a heat dependent process. Moreover excess of UVB rays also transform previtamin D3 into biologically inactive metabolites, tachysterol and lumisterol. On the other hand, the other precursor vitamin D2 is plant derived and its source is through diet. 1 Vitamin D has both endocrine and autocrine functions. The endocrine role of vitamin D is mainly in serum calcium homeostasis.The autocrine effects of vitamin D depend mainly on genetic transcription specific to the various types of cells expressing nuclear vitamin D receptors. These functions lead to inhibition of cell proliferation, promotion of cell differentiation and apoptosis. Thus vitamin D has an important role in modulation of calcium homeostasis, cardiovascular dynamics, musculoskeletal health and genetic expression. 4,5,6 In Dermatology, topical vitamin D and its analogues are being used since time immemorial in various conditions like vitiligo, psoriasis in the form calcitriol, calcipotriol, etc. Recently vitamin D deficiency and its reduced levels in serum has been seen in various skin diseases.

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Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

Shields,

Ly,

Wafae

et al. 2023

JAMA Dermatol

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ImportancePatients with acne are interested in nutraceuticals as a potential treatment option. However, there is uncertainty regarding the efficacy and safety of these products.ObjectiveTo evaluate the evidence for oral nutraceuticals in the treatment of acne.Evidence ReviewThe PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science databases were searched from inception through January 30, 2023, to identify randomized clinical trials evaluating oral nutraceutical interventions (ie, vitamins and minerals, botanical extracts, prebiotics, and probiotics) in individuals with acne. Clinician-reported outcomes (eg, investigator global assessment, lesion counts), patient-reported outcomes (eg, quality of life), and adverse events were extracted from the included studies. The quality of evidence was assessed using the Cochrane Risk of Bias checklist tool for randomized clinical trials. Based on the Risk of Bias tool, articles were converted to Agency for Healthcare Research and Quality standards of good, fair, or poor quality.FindingsA total of 2582 abstracts were identified in the database search, 42 of which met inclusion criteria (a total of 3346 participants). Studies of fair or good quality showed the potential benefit of vitamins B5 and D, botanical extracts (green tea), probiotics, and ω-3 fatty acids in the treatment of acne. These interventions were most frequently associated with decreased lesion counts or improved investigator global assessment scores. Adverse effects were rare for most of the therapies evaluated, but gastrointestinal tract adverse effects were reported for zinc therapy.Conclusions and RelevanceThis systematic review suggests a possible role for nutraceutical supplements in the treatment of acne. Physicians should be prepared to discuss the evidence regarding the potential role of nutraceuticals with patients. Many studies were of small size, and future research should focus on larger randomized clinical trials to assess the utility of nutraceuticals in the treatment of acne.

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Expression of inflammatory biomarkers from cultured sebocytes was influenced by treatment with vitamin D

Cited by 50 publications

References 21 publications

Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

Vitamin D levels in acne vulgaris patients treated with oral isotretinoin

Vitamin D and Its Role in Dermatology: A Review of Literature

Safety and Effectiveness of Oral Nutraceuticals for Treating Acne

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