Expression of insulin‐like growth factor II mRNA‐binding protein 3 in squamous cell carcinomas of the head and neck

Clauditz, Till S.; Wang, C.-J.; Gontarewicz, Artur; Blessmann, Marco; Tennstedt, Pierre; Borgmann, Kerstin; Tribius, Silke; Sauter, Guido; Dalchow, Carsten V.; Knecht, Rainald; Münscher, Adrian; Wilczak, Waldemar

doi:10.1111/j.1600-0714.2012.01178.x

Cited by 34 publications

(44 citation statements)

References 42 publications

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“…The 53 studies involved 8,937 patients with different cancer types, including 6 studies of RCC,8,25–29 6 lung cancer,9,30–34 4 oral cancer,10,35–37 4 urothelial carcinoma,38–41 4 ovarian cancer,16,17,42,43 3 hepatocellular carcinoma (HCC),44–46 4 colorectal cancer,12,47–49 3 prostate cancer,14,15,50 3 pancreatic cancer,51–53 2 gastric cancer,11,54 2 intrahepatic cholangiocarcinoma (ICC),55,56 and one study each of tongue cancer,57 thyroid carcinoma,58 sacral chordoma,59 pilocytic astrocytoma and pilomyxoid astrocytoma (PA/PMA),60 neuroblastoma,61 meningioma,62 melanoma,63 breast cancer,64 giant cell tumor,65 bile duct carcinoma,66 esophageal carcinoma,67 and cervical cancer 13. A total of 25 studies involved Caucasians and 28 involved Asians.…”

Section: Resultsmentioning

confidence: 99%

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

Chen¹,

Xie²,

Li³

et al. 2017

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BackgroundAccumulated studies have investigated the prognostic role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) in various cancers, but inconsistent and controversial results were obtained. Therefore, we performed a systematic review and meta-analysis to investigate the potential value of IMP3 in the prognostic prediction of human solid tumors.Materials and methodsA systematic literature search in the electronic databases PubMed, Embase, Web of Science, and Cochrane library (updated to April 2016) was conducted to identify eligible studies. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for survival outcomes were calculated and gathered using STATA 12.0 software.ResultsA total of 53 studies containing 8,937 patients with solid tumors were included in this meta-analysis. High IMP3 expression was significantly associated with worse overall survival (OS) of solid tumors (HR =2.08, 95% CI: 1.80–2.42, P<0.001). Similar results were observed in cancer-specific survival (CSS), disease-free survival (DFS), recurrence-free survival (RFS), progression-free survival (PFS), and metastasis-free survival (MFS). Further subgroup analysis stratified by tumor type showed that elevated IMP3 expression was associated with poor OS in renal cell carcinoma (RCC), lung cancer, oral cancer, urothelial carcinoma, hepatocellular carcinoma (HCC), colorectal cancer, pancreatic cancer, gastric cancer, and intrahepatic cholangiocarcinoma (ICC).ConclusionThe current evidence suggests that high IMP3 expression is associated with poor prognosis in most solid tumors. IMP3 is a potential valuable prognostic factor and might serve as a promising biomarker to guide clinical decisions in human solid tumors.

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Section: Resultsmentioning

confidence: 99%

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

Chen¹,

Xie²,

Li³

et al. 2017

OTT

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“…IMP3 overexpression in SCC of the oral cavity was shown to be an independent predictive marker for an advanced clinical stage, lymph node metastasis and as a prognostic indicator (29)(30)(31). Furthermore, it has been reported to be an indicator of a poor prognosis and a marker of enhanced malignancy in SCC of the tongue and larynx (32)(33)(34)(35). In addition, it has been shown to be expressed in certain malignant salivary gland tumors (36).…”

Section: Discussionmentioning

confidence: 98%

“…However, only a few studies have previously investigated the expression of IMP3 in head and neck SCC from specific sites (29)(30)(31)(32)(33)(34). In particular, the pattern of IMP3 expression in HNSCC with regards to the HPV status has not previously been investigated.…”

Section: Introductionmentioning

confidence: 99%

IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis

et al. 2017

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Abstract. Expression of p16 has been established as a good surrogate marker for high-risk human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) patients, and it has been associated with an improved prognosis, irrespective of the actual HPV status. Conversely, the human insulin-like growth factor II mRNA binding protein 3 (IMP3) has been related to aggressiveness in several types of tumors. The aim of the present study was to investigate and compare p16 and IMP3 as markers of favorable and unfavorable behavior, respectively, in head and neck SCC (HNSCC), with particular reference to the HPV status. Both markers were analyzed by immunohistochemical analysis of 156 HNSCC samples originating from the oropharynx (n=81), oral cavity (n=44), larynx (n=15), hypopharynx (n=10) and nasopharynx (n=6). The HPV status was examined in a randomly selected representative subcohort (n=38) using polymerase chain reaction. Of the 156 HNSCC samples, 81 (51.9%) and 54 (34.6%) were positive for IMP3 and p16, respectively. IMP3 expression (P=0.022), p16 expression (P<0.001) and the combination of these markers (P<0.001) were significantly associated with tumor site. In particular, 69/81 (85%) OPSCC samples were positive for either one or both markers compared with 36/75 (48%) SCC samples from other sites. p16 expression was significantly associated with HPV infection (P= 0.017) and a trend towards a negative association between IMP3 expression and HPV infection was observed (P=0.053). The results of the present study suggested that IMP3 and p16 are more frequently expressed in OPSCC compared with other HNSCCs. The prognostic impact of IMP3 on OPSCC remains to be investigated in a larger series with an extended follow-up period. IntroductionSquamous cell carcinoma (SCC) is the leading cancer type affecting the head and neck region (HNSCC) representing >90% of malignant neoplasms of the oral cavity and oropharynx and 5 and 2% of all cancers in men and women, respectively (1). Tobacco smoking and alcohol consumption are the two major etiological factors of HNSCC and they work in a synergistic manner to initiate SCC (1). Approximately 75% of HNSCC cases in western countries are related to these two major risk factors, while the remainder is predominantly associated with viral infection, in particular infection with high-risk human papillomavirus (HPV) (1). HPV has been detected in a small fraction of oral cavity SCCs, and in 40-50% of oropharyngeal (mainly tonsillar) SCC (OPSCC) (1). While HPV-associated HNSCC may occur at any site, including the sinonasal tract, the majority of HPV-related SCCs originate in the lymphoid tissue bearing the oropharynx, mainly the palatine tonsil and the base of the tongue (1). Expression of p16 as a consequence of oncogenic HPV infection has been increasingly used as a surrogate marker for high-risk HPV infection, particularly in the female genital tract and the oropharynx (2,3). The sensitivity and specificity of p16 immunostaining for detecting high-risk HPV in OPSCC patie...

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“…IGF2BP3 was first identified due to its high abundance in pancreatic carcinoma [6]. After its initial identification, IGF2BP3 has soon been explicated to be a mainly over-expressed member among the family in various tumor types, such as squamous cell carcinoma [7], lung cancer [8], melanoma [9], colon cancer [10], liver cancer [11]. And the aberrant upregulation implicated its potential oncogenic role in tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

et al. 2017

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BackgroundGastric cancer (GC) is one of the frequent causes of cancer-related death in eastern Asian population. IGF2BP2 lists in the top rank up-regulated genes in GC, but its functional role is unclear.MethodThe expression of IGF2BP3 in GC cell lines and primary samples was examined by qRT-PCR and Western blot. The biological role of IGF2BP3 was revealed by a series of functional in vitro studies. Its regulation by microRNAs (miRNAs) was predicted by TargetScan and confirmed by luciferase assays and rescue experiments.ResultsIGF2BP3 ranked the No.1 of the up-regulated genes by expression microarray analysis in GC cell lines. The expression level of IGF2BP3 was observed in GC tissues comparing with non-tumorous gastric epitheliums. The up-regulated IGF2BP3 expression was associated with poor disease specific survival. IGF2BP3 knockdown significantly inhibited cell proliferation and invasion. Apart from copy number gain, IGF2BP3 has been confirmed to be negatively regulated by tumor-suppressive miRNA, namely miR-34a. The expression of miR-34a showed negative correlation with IGF2BP3 mRNA expression in primary GC samples and more importantly, re-overexpression of IGF2BP3 rescued the inhibitory effect of miR-34a.ConclusionWe compressively revealed the oncogenic role of IGF2BP3 in gastric tumorigenesis and confirmed its activation is partly due to the silence of miR-34a. Our findings identified useful prognostic biomarker and provided clinical translational potential.Electronic supplementary materialThe online version of this article (doi:10.1186/s12943-017-0647-2) contains supplementary material, which is available to authorized users.

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Expression of insulin‐like growth factor II mRNA‐binding protein 3 in squamous cell carcinomas of the head and neck

Abstract: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression might be used as an independent prognostic factor in the subgroup of OSCC.

Cited by 34 publications

References 42 publications

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

Prognostic value of high IMP3 expression in solid tumors: a meta-analysis

IMP3 and p16 expression in squamous cell carcinoma of the head and neck: A comparative immunohistochemical analysis

IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

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