Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells

Zhang, Jing; Li, Yang; Chen, Jieli; Yang, Maozhou; Katakowski, Mark; Lü, Mei; Chopp, Michael

doi:10.1016/j.brainres.2004.09.061

Cited by 153 publications

(118 citation statements)

References 46 publications

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“…39,44 Although various growth factors are released from ischemic tissue, the factor responsible for promoting neuroblast differentiation appears to be unknown. Previous studies have shown that IGF-I is upregulated following ischemic injury, 45,46 and exogenous infusion of IGF-I enhances neural progenitor cell proliferation. 11 In contrast, other studies have shown that IGF-I induces the differentiation of neural progenitor cells 26 and, more specifically, instructs the differentiation of oligodendrocytes.…”

Section: Role Of Neural Stem Cellsmentioning

confidence: 97%

Growth factors, stem cells, and stroke

Kalluri

Dempsey

2008

FOC

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✓ Postischemic neurogenesis has been identified as a compensatory mechanism to repair the damaged brain after stroke. Several factors are released by the ischemic tissue that are responsible for proliferation, differentiation, and migration of neural stem cells. An understanding of their roles may allow future therapies based on treatment with such factors. Although damaged cells release a variety of factors, some of them are stimulatory whereas some are inhibitory for neurogenesis. It is interesting to note that factors like insulin-like growth factor–I can induce proliferation in the presence of fibroblast growth factor–2 (FGF-2), and promote differentiation in the absence of FGF-2. Meanwhile, factors like transforming growth factor–β can induce the differentiation of neurons while inhibiting the proliferation of neural stem cells. Therefore, understanding the role of each factor in the process of neurogenesis will help physicians to enhance the endogenous response and improve the clinical outcome after stroke. In this article the authors discuss the role of growth factors and stem cells following stroke.

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Section: Role Of Neural Stem Cellsmentioning

confidence: 97%

Growth factors, stem cells, and stroke

Kalluri

Dempsey

2008

FOC

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“…63 Several reports have focused on the role of neurotrophic factors such as an increase in insulin growth factor-1 (IGF1) and its receptor which may play a role in neuronal differentiation. Others have suggested that transplanted MSCs facilitate recovery from brain and spinal cord lesions by releasing brain natriuretic peptide (BNP) and other vasoactive factors to reduce edema, decrease intracranial pressure and improve cerebral perfusion.…”

Section: Human Mscsmentioning

confidence: 99%

Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury

Parr

Tator

Keating

2007

Bone Marrow Transplant

410

316

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“…24 h Produced many trophic factors; monocyte chemoattractant protein-1 [26,27] levels signifi cantly increased from 6 h, peaked at 48 h after MCAO, and enhanced BMSC migration and tissue repair Transient MCAO (2 h)/ i.v. 24 h hMSCs expressed bFGF and VEGF, promoted expression of insulin- [28][29][30] Permanent MCAO like growth factor 1 and receptor, which contributed to improved recovery and increased neurogenesis Transient MCAO (2 h) i.v. 24 h Cell-free MSC-generated exosomes survived, enhanced neurite [31,32] remodeling and angiogenesis, and improved functional recovery;…”

Section: Ischemic Strokementioning

confidence: 99%

Bone marrow stromal cells as a therapeutic treatment for ischemic stroke

Yang

Zhu

et al. 2014

Neurosci. Bull.

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Cerebral ischemia remains the most frequent cause of death and quality-of-life impairments due to neurological deficits, and accounts for the majority of total healthcare costs. However, treatments for cerebral ischemia are limited. Over the last decade, bone marrow stromal cell (BMSC) therapy has emerged as a particularly appealing option, as it is possible to help patients even when initiated days or even weeks after the ischemic insult. BMSCs are a class of multipotent, self-renewing cells that give rise to differentiated progeny when implanted into appropriate tissues. Therapeutic effects of BMSC treatment for ischemic stroke, including sensory and motor recovery, have been reported in pre-clinical studies and clinical trials. In this article, we review the recent progress in BMSC-based therapy for ischemic stroke, focusing on the route of delivery and pre-processing of BMSCs. Selecting an optimal delivery route is of particular importance. The ideal approach, as well as the least risky, for translational applications still requires further identification. Appropriate preprocessing of BMSCs or combination therapy has the benefi t of achieving the maximum possible restoration. Further pre-clinical studies are required to determine the time-window for transplantation and the appropriate dosage of cells.

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Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells

Cited by 153 publications

References 46 publications

Growth factors, stem cells, and stroke

Growth factors, stem cells, and stroke

Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury

Bone marrow stromal cells as a therapeutic treatment for ischemic stroke

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