Expression of islet neogenesis-associated protein in islets of normal hamsters

Flores, Luis; García, María Elisa; Borelli, María Inés; Zotto, H Del; Alzugaray, María Eugenia; Maiztegui, Bárbara; Gagliardino, Juan José

doi:10.1677/joe.0.1770243

Cited by 32 publications

(16 citation statements)

References 11 publications

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“…The fact that sucrose administration only induced an increase in INGAP cell mass when islet neogenesis occurred , together with our recent report of its transcription at islet level (Flores et al 2003) would reinforce this assumption.…”

Section: Discussionsupporting

confidence: 63%

Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors

Gagliardino

Zotto²,

Massa³

et al. 2003

Journal of Endocrinology

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The aim of this work was to study the possible relationship between pancreatic duodenal homeobox-1 (Pdx-1) and islet neogenesis-associated protein (INGAP) during induced islet neogenesis. Pregnant hamsters were fed with (S) and without (C) sucrose, and glycemia, insulin secretion in vitro, and pancreas immunomorphometric parameters were measured in their 7-day-old offspring. S offspring had significantly lower glycemic levels than C animals. Insulin release in response to increasing glucose concentrations in the incubation medium (2-16 mM glucose) did not increase in pancreata from either C or S offspring. However, pancreata from S offspring released more insulin than those from C animals. In S offspring, -cell mass, -cell replication rate and islet neogenesis increased significantly, with a simultaneous decrease in

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Section: Discussionsupporting

confidence: 63%

Pancreatic duodenal homeobox-1 and islet neogenesis-associated protein: a possible combined marker of activateable pancreatic cell precursors

Gagliardino

Zotto²,

Massa³

et al. 2003

Journal of Endocrinology

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“…In the mouse pancreas, Reg3δ is detected in exocrine cells and endocrine non-β-cells predominantly located at the islet periphery (18, 50, 51). When human, rat and hamster genomes were subjected to Southern blot hybridization with the mouse reg3 δ gene probe, bands appeared with sizes different than those of other Reg family members leading to the discovery of Reg3δ orthologs in these species.…”

Section: Reg Proteins In the Pancreasmentioning

confidence: 99%

Regenerating proteins and their expression, regulation, and signaling

Parikh

Stephan

Tzanakakis³

2012

BioMolecular Concepts

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The regenerating (Reg) protein family comprises C-type lectin-like proteins discovered independently during pancreatitis and pancreatic islet regeneration. However, an increasing number of studies provide evidence of participation of Reg proteins in the proliferation and differentiation of diverse cell types. Moreover, Reg family members are associated with various pathologies, including diabetes and forms of gastrointestinal cancer. These findings have led to the emergence of key roles for Reg proteins as anti-inflammatory, antiapoptotic and mitogenic agents in multiple physiologic and disease contexts. Yet, there are significant gaps in our knowledge regarding the regulation of expression of different Reg genes. In addition, the pathways relaying Reg-triggered signals, their targets and potential cross-talk with other cascades are still largely unknown. In this review, the expression patterns of different Reg members in the pancreas and extrapancreatic tissues are described. Moreover, factors known to modulate Reg levels in different cell types are discussed. Several signaling pathways, which have been implicated in conferring the effects of Reg ligands to date, are also delineated. Further efforts are necessary for elucidating the biological processes underlying the action of Reg proteins and their involvement in various maladies. Better understanding of the function of Reg genes and proteins will be beneficial in the design and development of therapies utilizing or targeting this protein group.

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“…INGAP gene encodes a 19,940 Da transcript [3], only produced in different subsectors of the pancreas (islets, duct and exocrine cells) [5]. A synthetic pentadecapeptide having the 104-118 aminoacids sequence of INGAP (INGAP-PP), reproduces the stimulatory effect of the intact molecule upon thymidine incorporation into pancreatic duct cells and duct-cell lines [3].…”

Section: Introductionmentioning

confidence: 99%