Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma

Mazal, Peter R.; Exner, Markus; Haitel, Andrea; Krieger, Sigurd; Thomson, Robert K.; Aronson, Peter S.; Susani, Martin

doi:10.1016/j.humpath.2004.09.011

Cited by 93 publications

(67 citation statements)

References 24 publications

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“…[31][32][33] However a marker with sufficient specificity to differentiate between chromophobe renal cell carcinoma and oncocytomas has not yet been unequivocally established. 17 Kidney-specific cadherin was found in one study to be almost exclusively expressed in chromophobe renal cell carcinoma, 34 however this finding was not supported by the others who found it also expressed in oncocytomas. 35 Similarly, cytokeratin 7 does not appear to show the consistent immunoreactivity in chromophobe renal cell carcinomas as suggested by some, preventing its utility for positive diagnostic differentiation from oncocytomas.…”

Section: Discussionmentioning

confidence: 87%

“…[28][29][30][31][32][33][34][35][36][37][38] Renal cell carcinoma marker antibody, CD10, glutathione S-transferase-a and others have shown specificity for clear cell renal cell carcinoma, 28,29 a-Methylacyl CoA racemase is expressed in papillary renal cell carcinoma, 30 whereas parvalbumin, b-defensin 1 and most recently KIT are used as markers for chromophobe renal cell carcinoma and oncocytoma. [31][32][33] However a marker with sufficient specificity to differentiate between chromophobe renal cell carcinoma and oncocytomas has not yet been unequivocally established.…”

Section: Discussionmentioning

confidence: 99%

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The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

et al. 2008

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This study evaluated the expression patterns of claudins 1, 3, 4, 7, and 8 in human renal cell carcinomas and oncocytomas and correlated expression with patient prognosis. Tissue microarrays were created from paraffinembedded tissue samples from 141 patients with renal cell carcinomas or oncocytoma (90 clear cell, 22 papillary, 17 chromophobe renal cell carcinomas, and 12 oncocytomas). The staining pattern for claudins 3, 4, 7, and 8 was membranous and/or cytoplasmic, whereas claudin 1 was predominantly membranous in both nonneoplastic renal tissue and tumors. Negative to weak claudin 3 staining was predominantly detected in Fuhrman's grade 1 and 2 clear cell renal cell carcinomas (78%; P ¼ 0.016), suggesting that upregulation of claudin 3 potentially occurs concomitantly with increasing grade of clear cell renal cell carcinomas. In addition, Kaplan-Meier univariate analysis showed a significant inverse correlation between moderate to strong claudin 3 and 4 expression with overall survival in clear cell renal cell carcinomas (P ¼ 0.038 and P ¼ 0.031). Moderate to strong claudin 7 expression was significantly more common in chromophobe renal cell carcinomas (94%) than in oncocytomas (55%; P ¼ 0.041). Claudin 8 staining was moderate to strong in 92% of oncocytomas, which differentiated them from papillary and clear cell renal cell carcinomas (14 and 12%; both Po0.0001). Only negative to weak claudin 8 staining was detected in all chromophobe renal cell carcinomas, whereas there were no claudin 8 negative oncocytomas and 8% exhibited a weak staining pattern (Po0.0001). Due to their distinctive expression patterns, claudins 7 and 8 can be used as useful immunohistochemical markers for the separation of chromophobe renal cell carcinomas from oncocytomas, whereas claudins 3 and 4 may serve as indicators of prognosis in clear cell renal cell carcinomas.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

et al. 2008

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“…Thus, as in breast tumors, 19,20 Snail is likely to influence the progress and potential for recurrence of renal carcinoma and the reactivation of its expression probably accounts for the loss of E-Cadherin and Cadherin-16 during tumor evolution. [21][22][23][24] We observed large areas in the tumor where E-Cadherin and Cadherin-16 had been lost. To gain further insight into the changes that occur during tumor development, we analyzed the expression of these two Cadherins in the normal tissue adjacent to the tumor.…”

Section: Involvement Of Snail Genes In Human Renal Carcinomamentioning

confidence: 74%

Reactivation ofSnailGenes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis?

Boutet¹,

Esteban²,

Maxwell³

et al. 2007

Cell Cycle

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“…Histology, ultrastructural examination and staining with Hale's colloidal iron can be used for their differentiation in daily practice. In recent years, there have been attempts to find an immunohistochemical marker that could also help in diagnostics (1,5,(15)(16)(17)19). …”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma

Demirović

Džombeta

Tomas

et al. 2010

Pathology - Research and Practice

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Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma

Cited by 93 publications

References 24 publications

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

The diagnostic and prognostic utility of claudin expression in renal cell neoplasms

Reactivation ofSnailGenes in Renal Fibrosis and Carcinomas: A Process of Reversed Embryogenesis?

Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma

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