Expression of leptin and its receptor in corpus luteum during estrous cycle in buffalo (Bubalus bubalis)

Kumar, Lalit; Panda, Rudra Prasanna; Hyder, Iqbal; Yadav, V.P.; Sastry, K.V.H.; Sharma, G. Taru; Mahapatra, R. K.; Bag, Sadhan; Bhure, S K; Das, G.; Mitra, Abhijit; Sarkar, Mihir

doi:10.1016/j.anireprosci.2012.08.030

Cited by 34 publications

(25 citation statements)

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“…The present findings agrees with the earlier observation in rat ovarian theca-interstitial cells [63,64], porcine granulosa-luteal cells [18,56,65], and bovine luteal cells [38] in which the IGF-1 treatment up-regulated the STARD1 mRNA, and STARD1 is believed to play an essential role in steroidogenesis [25]. The mRNA expression of key steroidogenic factors (STARD1, CYP11A1, and HSD3B) in buffalo was reported to be highest in mid-luteal phase [66]. Our findings of STARD1, CYP11A1, and HSD3B mRNA expression on IGF-1 treatment in cultured luteal cells of MLP also corroborates with the earlier findings in bovine luteal cells [38] and buffaloes [66].…”

Section: Discussionsupporting

confidence: 92%

“…The mRNA expression of key steroidogenic factors (STARD1, CYP11A1, and HSD3B) in buffalo was reported to be highest in mid-luteal phase [66]. Our findings of STARD1, CYP11A1, and HSD3B mRNA expression on IGF-1 treatment in cultured luteal cells of MLP also corroborates with the earlier findings in bovine luteal cells [38] and buffaloes [66]. The plasma progesterone profile in buffalo was found to follow similar pattern during estrous cycle [42], justifying our assumption that the enhanced expression of the above three factors in response to IGF-1 stimulation might boost up the steroidogenesis in CL.…”

Section: Discussionmentioning

confidence: 99%

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Stimulatory effect of luteinizing hormone, insulin-like growth factor-1, and epidermal growth factor on progesterone secretion and viability of cultured bubaline luteal cells

et al. 2014

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Stimulatory effect of luteinizing hormone, insulin-like growth factor-1, and epidermal growth factor on progesterone secretion and viability of cultured bubaline luteal cells

et al. 2014

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“…The CL was categorized into early luteal, mid luteal, late luteal and regressed stages with 10 CL at each stage. Further, luteal sample was frozen in liquid nitrogen and stored at -80 o C until RNA and protein extraction (Kumar et al, 2012).…”

Section: Collection Of Corpus Luteummentioning

confidence: 99%

“…The aspirated follicular fluid was stored at -20 o C for estimation of progesterone (P4). Normal follicles are having relatively constant levels of P4, so follicles having P4 concentration less than 100 ng/mL were utilized in the present study (Kumar et al, 2012). Follicles were frozen with the help of liquid nitrogen and stored at -80 o C.…”

Section: Follicles Collectionmentioning

confidence: 99%

“…According to FAOSTAT (2012), there are 194.2 million heads of buffalo in the world, of which 115.4 million is in India (59.4% of total world population). High milk yield with more fat content, good feed conversion efficiencies, comparatively higher disease resistant than the bovines are the peculiarities of the buffaloes (Kumar et al, 2012). Owing to the versatility of buffaloes, they are called "black gold" by the farmers (Bilal et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Expression and localization of bone morphogenetic protein6 (BMP6) in the corpus luteum during different stages of estrous cycle in the buffalo (Bubalus bubalis)

Rajesh¹,

Paul²,

Jaya³

et al. 2016

JEBAS

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Emerging evidence suggests that Bone Morphogenetic Proteins (BMPs), which belong to the Transforming Growth Factor-β (TGF-β) super-family, are known to be involved in the follicular growth and steroid production in different species. This study describes BMP6 bearing in corpus luteum over various stages of estrous cycle. The bubaline CL was classified into four stages according to the morphology and progesterone (P4) concentration. The real time PCR and immunoblot studies revealed that BMP6 was significantly (P<0.05) unregulated during the mid stage of CL that was consistent with immunohistochemical localization in the luteal cells. The transcriptional and translational expressions of BMP6 in the early and late CL were comparable and significantly (P<0.05) lower than that of mid CL. In conclusion, BMP6 expression is dependent on the stage of CL in the buffalo.

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Circulating leptin and NF‐κB activation in peripheral blood mononuclear cells across the menstrual cycle

et al. 2016

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Using the menstrual cycle as a model, this study focused on longitudinal changes and associations within a physiological network known to play a role in female fertility, including, as biologically active nodes, NF-jB, leptin and adiponectin, bcarotene, adipose tissue, and progesterone. In 28 women, leptin, adiponectin, b-carotene, and progesterone concentrations, NF-jB p65 and p50 activation in peripheral blood mononuclear cells (known to possess estrogen, progesterone and leptin receptors), total body fat (TBF) and subcutaneous adipose tissue (SAT) mass were determined at early (T1) and late follicular (T2) and mid (T3) and late (T4) luteal phase. Leptin and adiponectin concentrations were higher, while NF-jB p65 activation was lower at T3 compared with T1. NF-jB p65 activation was inversely related to leptin concentrations at T1, T3, and T4. b-Carotene was inversely related to leptin (T1,T2,T4) and SAT (T1,T3,T4). NF-jB p50 activation was inversely related to TBF (T4) and SAT (T3,T4), and leptin was positively related to TBF and SAT (T1-T4). Progesterone was inversely related to leptin (T2,T3), adiponectin (T3), TBF (T3,T4), and SAT (T2,T3,T4). By providing evidence of luteal phase-specific reduced NF-jB p65 activation in women under physiological conditions, this study bridges the gap between existing evidence of a Th1-Th2 immune response shift induced by reduced NF-jB p65 activation and a Th1-Th2 shift previously observed at luteal phase. For the first time, inverse regressions suggest inhibitory effects of leptin on NF-jB p65 activation at luteal phase, along with inhibitory effects of

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Expression of leptin and its receptor in corpus luteum during estrous cycle in buffalo (Bubalus bubalis)

Cited by 34 publications

References 50 publications

Stimulatory effect of luteinizing hormone, insulin-like growth factor-1, and epidermal growth factor on progesterone secretion and viability of cultured bubaline luteal cells

Stimulatory effect of luteinizing hormone, insulin-like growth factor-1, and epidermal growth factor on progesterone secretion and viability of cultured bubaline luteal cells

Expression and localization of bone morphogenetic protein6 (BMP6) in the corpus luteum during different stages of estrous cycle in the buffalo (Bubalus bubalis)

Circulating leptin and NF‐κB activation in peripheral blood mononuclear cells across the menstrual cycle

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