Expression of Leptin and Visfatin in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Using Enzyme‐Linked Immunosorbent Assay and Real‐Time Polymerase Chain Reaction

Ghallab, Noha A.; Amr, Eman; Shaker, Olfat G.

doi:10.1902/jop.2015.140434

Cited by 21 publications

(23 citation statements)

References 55 publications

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“…In this study, it was found that saliva visfatin levels were higher in patients with periodontitis than in the healthy individuals, which decreased at 3 months and remained low until 6 months. In several studies, high levels of visfatin have been reported in saliva, GCF, and periodontal tissue in periodontitis 6,7,41‐43 . In contrast, visfatin GCF and saliva levels have been reported to decrease after NSPT 15–18 .…”

Section: Discussionmentioning

confidence: 99%

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Özcan¹,

Saygun²,

Serdar³

et al. 2016

Journal of Periodontology

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Section: Discussionmentioning

confidence: 99%

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Özcan¹,

Saygun²,

Serdar³

et al. 2016

Journal of Periodontology

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“…Adipokines are molecules with a protein structure, involved in various systemic events such as the regulation of glucose released from the adipose tissue, homeostasis, inflammation, and healing 34 . They play an important role in many diseases, especially diabetes and obesity 14 , 15 , 34 . The increased expression of some adipokines is known to be associated with BMI and age 16 .…”

Section: Discussionmentioning

confidence: 99%

“…In individuals with periodontitis, in the presence of systemic inflammatory diseases and conditions such as rheumatoid arthritis, diabetes, and obesity, inflammatory response of the tissue may vary, and the periodontal breakdown can be more prevalent 12 . Although the underlying mechanisms have not been determined precisely, it has been speculated that adipokines might represent an important pathophysiologic link between periodontitis and systemic diseases 13–15 . Recently, some adipokines are reported to play a role in immune regulation and the inflammatory process 16 …”

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confidence: 99%

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Porphyromonas gingivalis and Epstein‐Barr Virus Are Associated With Increased Levels of Visfatin in Gingival Crevicular Fluid

Ozcan¹,

Saygun²,

Serdar

et al. 2016

Journal of Periodontology

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“…Adipokines are thought to act via their impact on insulin sensitivity, which is why fluctuating levels of these hormones are linked to T2DM (29). Recently, Ogawa et 0.000* 0.000* 0.000* 0.000* 0.000* 0.000* 0.000* 0.000* 0.000* CTRL, systemically and periodontally healthy control group; DM-CTRL, type 2 diabetes with periodontally healthy group; CP, chronic periodontitis without type 2 diabetes group; DM-CP, chronic periodontitis with type 2 diabetes group; TNF-α, tumor necrosis factor-alpha; GI, gingival index; CAL, clinical attachment level; HbA1c, glycated haemoglobin A1c.…”

Section: Discussionmentioning

confidence: 99%

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

et al. 2016

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Abstract:The aims of the present study were to determine the levels of vaspin and omentin-1 in gingival crevicular fluid (GCF) in patients with chronic periodontitis (CP) with and without type 2 diabetes mellitus (T2DM), and to evaluate GCF vaspin and omentin-1 levels after non-surgical periodontal therapy. The study included 60 subjects: 15 systemically and periodontally healthy individuals, 15 periodontally healthy patients with T2DM, 15 systemically healthy patients with CP, and 15 patients with both CP and T2DM. GCF and clinical periodontal parameters were examined at the baseline and 6 weeks after periodontal therapy. Levels of vaspin, omentin-1 and tumor necrosis factor-alpha (TNF-α) were measured by ELISA, and their relative ratios were calculated. GCF vaspin and TNF-α levels were significantly higher in the CP groups than in the periodontally healthy groups (P < 0.008) and decreased after therapy in the former (P < 0.025). GCF omentin-1 levels were significantly lower in the CP groups than in the periodontally healthy groups (P < 0.008) and increased after therapy in the former (P < 0.05). Statistically significant positive correlations were found between the total amount of vaspin and TNF-α, glycated hemoglobin (HbA1c), clinical attachment level and gingival index, whereas the level of omentin-1 was negatively correlated with these parameters in all groups (P < 0.05). We found that non-surgical periodontal therapy influenced the GCF levels of both vaspin and omentin-1 in the CP groups. IntroductionChronic peridontitis (CP) is an infectious condition that degrades and deteriorates the vital periodontal tissues around the teeth (1). The deterioration of soft and hard tissues resulting from periodontitis is due to stimulation of the host immunoinflammatory reaction to pathogens in the mouth (2). The host response to these infectious pathogens leads to dispersal of inflammatory mediators, including the pro-inflammatory cytokines interleukin-1 (IL-1), IL-6, tumor necrosis factor alpha (TNF-α), and prostaglandins (PGE2), the latter exacerbating deterioration of the periodontium. The increased cytokine levels present in periodontitis are also likely to aggravate existing conditions, such as atherosclerosis, diabetes, and rheumatoid arthritis (3). A number of theories have been offered to explain the

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Expression of Leptin and Visfatin in Gingival Tissues of Chronic Periodontitis With and Without Type 2 Diabetes Mellitus: A Study Using Enzyme‐Linked Immunosorbent Assay and Real‐Time Polymerase Chain Reaction

Abstract: Expression of leptin and visfatin in the gingival tissues suggests a possible role for these adipokines in the pathogenesis of CP and T2DM.

Cited by 21 publications

References 55 publications

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Porphyromonas gingivalis and Epstein‐Barr Virus Are Associated With Increased Levels of Visfatin in Gingival Crevicular Fluid

Levels of vaspin and omentin-1 in gingival crevicular fluid as potential markers of inflammation in patients with chronic periodontitis and type 2 diabetes mellitus

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