<i>Porphyromonas gingivalis</i> and Epstein‐Barr Virus Are Associated With Increased Levels of Visfatin in Gingival Crevicular Fluid

Ozcan, Erkan; Saygun, N. Isxõl; Serdar, Muhittin; Kubar, Ayhan; Bengi, V. Umut

doi:10.1902/jop.2015.150424

Cited by 20 publications

(27 citation statements)

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“…In contrast, visfatin GCF and saliva levels have been reported to decrease after NSPT 15–18 . In another study by the present authors’ research group, it was suggested that the microbiologic agents that colonize the subgingival region in periodontitis can increase visfatin expression 19 . In this respect, the results obtained from the present study are consistent with the literature.…”

Section: Discussionsupporting

confidence: 91%

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Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Özcan¹,

Saygun²,

Serdar³

et al. 2016

Journal of Periodontology

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Section: Discussionsupporting

confidence: 91%

“…Its role in periodontal inflammation has been demonstrated in several recent studies. Increased levels in saliva and gingival crevicular fluid (GCF) were found to decrease after non‐surgical periodontal therapy (NSPT) 15–19 . Chemerin is another proinflammatory adipokine with a different mechanism 20 .…”

mentioning

confidence: 99%

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Özcan¹,

Saygun²,

Serdar³

et al. 2016

Journal of Periodontology

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“…This reduction was smaller after 3 and 6 months. Özcan et al (40) showed that P. gingivalis infection in the periodontal pockets and EBV in plaque increase visfatin secretion. We evaluated the correlation between visfatin levels and periodontal pocket depth and found that these were positively correlated.…”

Section: Discussionmentioning

confidence: 99%

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

et al. 2016

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The purpose of this study was to evaluate visfatin levels at different stages of periodontal disease and in healthy tissues. In addition, the effect of non-surgical periodontal therapy on visfatin levels in gingival crevicular fluid and serum was investigated. Forty-five patients were divided into three groups based on clinical and radiographical findings. Group 1 comprised periodontally healthy individuals (n = 15); group 2 comprised patients with gingivitis (n = 15); and group 3 was composed of patients with generalized chronic periodontitis (n = 15). Gingival crevicular fluid and serum samples were collected before treatment and at 1, 3, and 6 months after treatment. Visfatin levels were measured by enzymelinked immunosorbent assays. Gingival crevicular fluid and serum visfatin levels were higher in patients with chronic periodontitis than those with gingivitis or healthy controls (P < 0.016). In addition, visfatin levels were higher in the gingivitis group than in healthy controls (P < 0.016). Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels.

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“…EBV-infected periodontium tends to harbor high levels of periodontopathic bacteria. Viral and bacterial co-existences were reported more frequently in deeper PD sites of CP patients [29,30]. We have previously reported that coexistence of EBV DNA and P. gingivalis was significantly higher in CP patients with deeper PD sites (> 5 mm; 40%) than in those with shallow PD sites (< 3 mm; 14%) or healthy controls (13%) [18].…”

Section: Discussionmentioning

confidence: 90%

“…Therefore, EBV could be involved in the etiology of several types of periodontitis [18,[27][28][29]. In this study, we examined whether higher prevalence of EBV DNA and P. gingivalis are associated with PS in Japanese CP patients and IPT could decrease the number of EBV and P. gingivalis in the subgingival plaque, because several studies suggest that EBV and P. gingivalis act synergistically to potentiate periodontal disease progression and tissue destruction [18,19,21,29,30]. In this study, EBV DNA and P. gingivalis coexist in the PS of CP patients at high frequency (70.6%).…”

Section: Discussionmentioning

confidence: 99%

Effects of initial periodontal therapy on the prevalence of Epstein-Barr virus DNA and Porphyromonas gingivalis in Japanese chronic periodontitis patients

Kato

Ikeda

Imai

et al. 2019

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Background Initial periodontal therapy (IPT) is cornerstone of periodontal therapy and the first step to control of periodontal risk factors. Scaling and root planing are used to treat root surface irregularities and remove virulent factors caused by periodontal pathogens. This procedure also incorporated into periodontal surgery. To elucidate the effects of IPT on prevalence of Epstein-Barr virus (EBV) DNA and Porphyromonas gingivalis , we used subgingival plaque samples from chronic periodontitis (CP) patients.Methods Seventeen CP patients were recruited and determined measured periodontal status clinical parameters such as by probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP) and an X-ray examination, and subgingival plaque samples were collected from two periodontal sites with PD of < 3 mm (healthy sites: HS) or > 5 mm (periodontitis sites: PS) at first visit and after IPT. Plaque samples were subjected to a real-time PCR to detect EBV DNA and P. gingivalis.Results EBV DNA and P. gingivalis were detected 9 (52.9%) and 14 (82.3%) sites within the subgingival samples from HS, and 13 (76.5%) and 14 (82.3%) sites within the PS at first visit. After IPT, number of detections of EBV DNA and P. gingivalis were decreased to 5 (29.4%) and 13 (76.5%) sites within the subgingival samples from HS, and 9 (52.9%) and 10 (58.8%) sites within the PS. Significant improvements in PD and BOP were observed after IPT in PS. Coexistence of EBV DNA and P. gingivalis in the subgingival samples from PS at first visit (12 sites; 70.6%) were significantly decreased after IPT (6 sites; 35.3%).Conclusion These results suggest that the IPT was effective in improvement of clinical parameters such as PD and BOP and reducing the coexistence of EBV and P. gingivalis in the subgingival plaque from PS. However, IPT could not eradicate the EBV and P. gingivalis . Further research would be necessary for improving the periodontal treatment strategy.

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Porphyromonas gingivalis and Epstein‐Barr Virus Are Associated With Increased Levels of Visfatin in Gingival Crevicular Fluid

Cited by 20 publications

References 50 publications

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Non‐Surgical Periodontal Therapy Reduces Saliva Adipokine and Matrix Metalloproteinase Levels in Periodontitis

Visfatin levels in gingival crevicular fluid and serum before and after non-surgical treatment for periodontal diseases

Effects of initial periodontal therapy on the prevalence of Epstein-Barr virus DNA and Porphyromonas gingivalis in Japanese chronic periodontitis patients

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