Expression of leukaemia inhibitory factor (LIF) during the window of implantation in copper T380A intrauterine device users

Güney, Mehmet; Oral, Baha; Karahan, Nermin; Mungan, Tamer

doi:10.1080/13625180701441261

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…These data suggest that some of these factors may also be regulating FAAH expression in the uterus. The main controlling factors discovered so far for the control of FAAH expression are progesterone (Maccarrone et al 2003), leptin (Gasperi et al 2005), and leukaemia inhibitory factor (LIF; (Deutsch et al 2002)) which are all elevated during this phase of the menstrual cycle , 2009cGuney et al 2007;Ludwig et al 2000). Although relatively little is known about the factors that regulate NAPE-PLD expression, some have speculated that the tight reciprocal regulation between FAAH and NAPE-PLD in the rodent implantation site (Guo et al 2005;Paria et al 1996;2001;Ueda et al 2000Ueda et al , 2005 is suggestive of a similar but inverted regulatory pathway for NAPE-PLD and FAAH expression.…”

Section: Discussionmentioning

confidence: 98%

Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle

Taylor

Abbas

Habiba

et al. 2010

Histochem Cell Biol

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Plasma anandamide (AEA) levels fluctuate throughout the menstrual cycle and in early pregnancy in a pattern suggesting its involvement in implantation and early pregnancy maintenance through mechanisms that might involve its binding to cannabinoid receptors CB1 and CB2. Plasma AEA levels are maintained by the actions of the enzymes fatty acid amide hydrolase (FAAH) and N-acylphosphatidylethanolamine-phospholipase D (NAPE-PLD). All of these component parts of the 'endocannabinoid system' have been demonstrated in rodent but not in human uteri. This study aimed to demonstrate the presence of the endocannabinoid system in the human uterus and catalogue its modulation. Immunohistochemical techniques were employed to localise and determine the distribution of immunoreactive CB1, CB2, FAAH, and NAPE-PLD in well-characterised menstrual cycle biopsy samples. Immunoreactive CB1 and CB2 were widely distributed throughout the uterine tissue. In the myometrium and endometrium, smooth muscle cells were immunoreactive, although the vascular smooth muscle cells in both tissues were more so. In the endometrium, CB1 and CB2 immunoreactivity was primarily restricted to the glandular epithelium and expression was unrelated to the phase of the cycle. FAAH immunoreactivity in the endometrium was highest in the mid-proliferative gland and mid-secretory stroma, whilst NAPE-PLD immunoreactivity was down-regulated in the secretory epithelial gland compared to the proliferative epithelial gland and unaffected in the stroma. These data indicate that elements of the 'endocannabinoid system' coexist in many cell types within the uterus and may provide insight into the sites of action of endogenous and exogenous cannabinoids during endometrial transformation.

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Section: Discussionmentioning

confidence: 98%

Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle

Taylor

Abbas

Habiba

et al. 2010

Histochem Cell Biol

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“…LIF is a pleiotropic cytokine of IL-6 family that is considered as one of the cytokines essential for the successful completion of human pregnancy 13 , 14 . It was initially identified as a cytokine having the ability to inhibit proliferation of mouse myeloid leukemic cells and induce their differentiation into macrophages 15 .…”

Section: Leukemia Inhibitory Factormentioning

confidence: 99%

LIF-STAT signaling and trophoblast biology

2013

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Leukemia inhibitory factor (LIF) is a pleiotropic growth factor that regulates several biological functions. This review focuses on the LIF-dependent STAT activation and its impact on modulation of trophoblast functions during embryo implantation. LIF is mainly produced by the maternal endometrium at the time of implantation while its receptors are present both on the endometrium and trophoblasts. It might influence blastocyst attachment through STAT3 activation and expression of integrins. After attachment of the blastocyst, trophoblasts undergo proliferation and differentiation into invasive EVTs and non-invasive STBs. Under in vitro conditions, LIF regulates all these processes through activation of STAT- and MAPK-dependent signaling pathways. The observations that LIF and STAT3 knockout mice are infertile further strengthen the notion about the critical involvement of LIF-mediated signaling during embryo implantation. Hence, a better understanding of LIF-STAT signaling would help in improving fertility as use of LIF in in vitro blastocyst culture improves the implanting ability of blastocyst after IVF.

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“…In humans, LIF regulates various functions and is produced by several types of cells, such as fibroblasts, osteoblasts, hepatocytes, monocytes, macrophages and T cells (Mathieu et al, 2012;Metcalf, 2003). It plays a critical role in the reproductive process and is considered essential to successful pregnancy in humans (Franasiak et al, 2014;Fritz et al, 2014;Güney et al, 2007;Kimber, 2005). A higher concentration of LIF in the follicular fluid is correlated with embryo quality, which suggests that LIF has an important role in the physiology of ovulation and early embryonic development (Arici et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Association between leukaemia inhibitory factor gene polymorphism and pregnancy outcomes after assisted reproduction techniques

Oliveira

Vagnini

Petersen

et al. 2016

Reproductive BioMedicine Online

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Certain gene polymorphisms are associated with implantation failure and pregnancy loss. Studies of leukaemia inhibitory factor (LIF) gene polymorphisms are scarce. The LIF single nucleotide polymorphism (SNP) thymine (T)/guanine (G) (rs929271) was studied in women to determine whether an association existed with pregnancy outcomes after intracytoplasmic sperm injection (ICSI); 411 women who underwent ICSI were recruited. DNA was extracted from the peripheral blood, and the LIF gene SNP T/G (rs929271) was genotyped using real-time polymerase chain reaction. Participants were divided into three groups according to their LIF genotype: T/T (n = 168), T/G (n = 202) and G/G (n = 41). All IVF and ICSI procedures were carried out under the same clinical and laboratory conditions. The ICSI cumulative results (from fresh plus frozen cycles) of each genotype group were analysed. The G/G genotype in women was associated with a higher implantation rate (T/T: 15.9%, T/G: 16.2%, G/G: 27.0%; P < 0.05), ongoing pregnancy rate/patient (T/T: 31.5%, T/G: 36.1%, G/G: 53.7%; P < 0.05) and ongoing pregnancy rate/transfer (T/T: 18.5%, T/G: 20.2%, G/G: 36.7%; P < 0.05). LIF SNP T/G (rs929271) seems to be a susceptibility biomarker capable of predicting implantation efficiency and pregnancy outcomes.

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Expression of leukaemia inhibitory factor (LIF) during the window of implantation in copper T380A intrauterine device users

Abstract: Copper IUDs can inhibit expression of LIF and they may cause inhibition of the implantation stage, which is crucial for pregnancy.

Cited by 9 publications

References 19 publications

Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle

Histomorphometric evaluation of cannabinoid receptor and anandamide modulating enzyme expression in the human endometrium through the menstrual cycle

LIF-STAT signaling and trophoblast biology

Association between leukaemia inhibitory factor gene polymorphism and pregnancy outcomes after assisted reproduction techniques

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