Expression of Matrix Metalloproteinases (MMP‐8 and ‐9) in Chronic Periodontitis Patients With and Without Diabetes Mellitus

Muthusamy, Senthilkumar; Vamsi, Gelli; Sripriya, R.; Sehgal, Praveen Kumar

doi:10.1902/jop.2006.050293

Cited by 216 publications

(103 citation statements)

References 38 publications

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“…We found that MMP-8 increases in patients who are diabetic as compared to control which is in accordance with the study of Kumar et al (28) who reported a significant increase in gingival tissue MMP 8 level in diabetic patients having chronic periodontitis as compared to controls. Another study by Gupta et al (29) also reported a rise in salivary MMP-8 levels as compared to nondiabetic controls.…”

Section: Discussionsupporting

confidence: 92%

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Gupta

Garg

et al. 2016

J Oral Sci

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The present study was carried out to evaluate the effect of type 2 diabetes mellitus (DM) and smoking on periodontal parameters and on the levels of salivary matrix metalloproteinase (MMP-8). One hundred and twenty five subjects were divided into five groups: group 1, systemically and periodontally healthy subjects (n = 25); group 2, systemically healthy subjects but with chronic periodontitis (n = 25); group 3, subjects with type 2 DM and chronic periodontitis (n = 25); group 4, smokers with chronic periodontitis (n = 25); group 5, diabetic-smokers with chronic periodontitis (n = 25). MMP-8 level in saliva was estimated by enzyme linked immunosorbent assay (ELISA) using Quantikine human total MMP-8 immunoassay kit. The result showed that the clinical periodontal parameters and the mean levels of the salivary MMP-8 were significantly higher for diabetic-smokers than other study groups. A highly significant positive correlation (r) between MMP-8 and periodontal parameters was also observed in diabetic-smoker patients. The findings suggest that diabetic-smokers have increased periodontal breakdown and are associated with an increased extent and severity of periodontitis. (J Oral Sci 58, 1-6, 2016)

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Section: Discussionsupporting

confidence: 92%

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Gupta

Garg

et al. 2016

J Oral Sci

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“…In our study, nicotine administration caused a change in fibroblast activity due to the change of collagene fiber synthesis and decreased MMP2 expression. Several MMPs have been identified in the inflamed gingival tissues: MMP-1, -2, -3, -8, -9, -13, produced by the keratinocytes, macrophages, polymorphonuclear leukocytes [2,3,6,26,27]. Their activity could be different depending on the severity of disease and the needs for extracellular matrix digestion.…”

Section: Discussionmentioning

confidence: 99%

Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

et al. 2018

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Nicotine is associated with increased incidence of periodontal disease and poor response to therapy. This article aimed at identifying the expression of Matrix metalloproteinases-2 (MMP2) and Vascular endothelial growth factor (VEGF) proteins on extracellular matrix, fibrous distribution and angiogenetic development in periodontitis caused by nicotine effects on periodontal membrane. In this experimental study, the groups were divided into nicotine and control groups. While the nicotine groups in rats (n=6) were administered 2mg/kg Nicotine sulphate for 28 days, the control group in rats (n=6) were only administered 1,5 ml physiologic saline solution subcutaneously for 28 days. Histological sections were prepared and immunohistochemically stained for MMP2 and VEGF. The sections were stained with Trichrome-Masson were observed under light microscope. VEGF and MMP2 immunoreactivity of periodontal gingiva and dentin was assessed by immunohistochemical staining. In conclusion, nicotine effect reduces Matrix metalloproteinases production and disrupt collagen synthesis and causes periodontitis. We observed that nicotine increases periodontitis by disrupting periodontal membrane and prevent tooth to anchor in dental alveoli by disrupting epithelial structure.

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“…A study suggested that MMP-9 levels in the gingival crevicular fluid are higher in chronic periodontitis group than in patients with gingivitis and healthy subjects [23]. Similarly another study demonstrated an increased concentration of MMP-9 in the gingival tissue of diabetic chronic periodontitis patients suggests that the expression of these MMPs contributes to the failure of the healing process in the diabetic condition [24]. Prostaglandin E2 and MMP-9 both are well known pro-inflammatory markers for periodontal disease and BTC induces upregulation of both of these markers.…”

Section: Groupmentioning

confidence: 99%

Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study

Ugale

Kalburgi

Bilichodmath

et al. 2015

JCDR

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Expression of Matrix Metalloproteinases (MMP‐8 and ‐9) in Chronic Periodontitis Patients With and Without Diabetes Mellitus

Cited by 216 publications

References 38 publications

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels

Effects of nicotine administration in rats on MMP2 and VEGF levels in periodontal membrane

Betacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study

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