Expression of miR-320 and miR-204 in myocardial infarction and correlation with prognosis and degree of heart failure

Abstract

Myocardial infarction is a very dangerous cardiovascular disease with a high mortality rate under the modern developed medical technology. miRNA is a small molecule regulatory RNA discovered in recent years, which can play an important role in many cancers and other diseases. Medical data, machine learning and medical care strategies supporting the Internet of Things (IoMT) have certain applications in the treatment of myocardial infarction. However, the specific pathogenesis of myocardial infarction is still unclear. Therefore, this paper aimed to explore the expression of microRNA-320 and microRNA-204 in myocardial infarction and used the expression of microRNA-320 and microRNA-204 to predict the prognosis of patients with myocardial infarction. In order to discuss the expression of microRNA-320 and microRNA-204 in myocardial infarction in more detail. In this paper, 40 patients in the trial period were selected for clinical research, and 10 patients with normal cardiac function were selected in NHF group as control group. 10 patients with heart failure were selected as AMHF group. 10 patients with acute myocardial infarction were selected as AMNHF group. 10 patients with heart failure after old myocardial infarction were selected as OMHF group. AMHF group, AMNHF group and OMHF group were taken as the case group. This paper analyzed the difference of miR between different groups and determined that there were significant differences in the expression of miR-320 and miR-204 between different groups. Finally, the expression and prognosis of miR-320 and miR-204 in myocardial infarction were analyzed. The analysis results showed that the expression of microRNA-320 and microRNA-204 can inhibit the activity of myocardial cells. On the fifth day, the corresponding expression of microRNA-320 and microRNA-204 reduced the optical density of myocardial cells to 1.75 and 1.76, which was significantly lower than that on the first day. Moreover, excessive miR-320 expression and excessive miR-204 expression can increase the apoptosis rate of myocardial cells. The above results indicated that the high expression of microRNA-320 and microRNA-204 can be a bad prognostic factor in patients with myocardial infarction, showing that medical data, machine learning and medical care strategies supporting IoMT can play a role in the treatment of myocardial infarction. Therefore, it is urgent to understand the pathogenesis of heart failure after myocardial infarction and find new treatment schemes to improve the positive prognosis.

Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs

“…Human MI [217] Human 13 PAH [218] I/R injury in rats [219] SIRT1 [220] Enhanced antioxidant response via deacetylation of FOXO3a [107] miR-381 Human atherosclerosis [222] 14 HG treated 15 VSMCs [224] HMGB1 [224] Enhanced HMGB1-mediated NOX activation and subsequent ROS production [157,158] 16 COX-2 [222] Enhanced Nrf2 transcriptional activity by producing 17 EFOXs that can induce Keap1-Cul3 ubiquitination system [226,228] miR-708…”

“…Mir-204 is one of the miRNAs down-regulated in human MI [ 217 ] and PAH [ 218 ], and its down-regulation has also been reported in a rat model of myocardial I/R injury [ 219 ]. Additionally, the involvement of miR-204 in the regulation of oxidative stress has been demonstrated in a study that examined the role of miR-204 in endoplasmic reticulum (ER) stress-induced endothelial dysfunction [ 220 ].…”