Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation

Duan, Fujiao; Peng, Zhen; Yin, Jingjing; Yang, Zhongyu; Shang, Jia

doi:10.7150/jca.36469

Cited by 12 publications

(7 citation statements)

References 61 publications

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“…The MMP-14 gene plays a crucial role in many biological and pathological conditions and activation of proMMP2 [ 92 , 100 ]. The role of MMP-14 in angiogenesis and cancer invasion has been identified by previous investigations [ 101 , 102 , 103 ]. Cui et al, observed statistically significant associations between the overexpression of MMP-14 gene in CRC compared to normal mucosa.…”

Section: The Function Of Mmps In Colorectal Polyps and Cancermentioning

confidence: 93%

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian

Nobili

Peyravian

et al. 2021

Cancers

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Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis

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Section: The Function Of Mmps In Colorectal Polyps and Cancermentioning

confidence: 93%

Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer

Pezeshkian

Nobili

Peyravian

et al. 2021

Cancers

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“…Interestingly, MMP-14 and α5β1integrin have the common functions of activating MMP-2 [108][109][110][111] and stimulating tumor angiogenesis [112,113]. However, there is also a study in which no correlation was observed between MMP-14 expression and the prognosis of CRC [114]. Collectively, these studies suggest that MMP-14 may be a biomarker in CRC, but further studies are needed.…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

Extracellular Matrix Biomarkers in Colorectal Cancer

Kim

et al. 2021

IJMS

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The cellular microenvironment composition and changes therein play an extremely important role in cancer development. Changes in the extracellular matrix (ECM), which constitutes a majority of the tumor stroma, significantly contribute to the development of the tumor microenvironment. These alterations within the ECM and formation of the tumor microenvironment ultimately lead to tumor development, invasion, and metastasis. The ECM is composed of various molecules such as collagen, elastin, laminin, fibronectin, and the MMPs that cleave these protein fibers and play a central role in tissue remodeling. When healthy cells undergo an insult like DNA damage and become cancerous, if the ECM does not support these neoplastic cells, further development, invasion, and metastasis fail to occur. Therefore, ECM-related cancer research is indispensable, and ECM components can be useful biomarkers as well as therapeutic targets. Colorectal cancer specifically, is also affected by the ECM and many studies have been conducted to unravel the complex association between the two. Here we summarize the importance of several ECM components in colorectal cancer as well as their potential roles as biomarkers.

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“…[18] Duan et al performed a meta-analysis and databases validation to explore the prognostic value of MMP14 expression in digestive system carcinoma, and found that high MMP14 expression might predict poor prognosis in digestive system carcinoma, including GC. [19] Dong et al study showed that MMP14 expression was overexpressed in GC tissues compared to normal tissues, and high MMP14 expression was associated with unfavorable clinicopathological parameters, such as earlier lymph node metastasis and advanced clinical stage. [9] Similarly, Tian et al also found that high MMP14 expression was associated with earlier lymph node or distant metastasis, advanced clinical stage and shorter overall survival (OS) when compared to low MMP14 expression in GC.…”

Section: Introductionmentioning

confidence: 99%