Expression of MMP‐2 is associated with progression and lymph node metastasis of gastric carcinoma

Mönig, Stefan P.; Baldus, Stephan; Hennecken, J. K.; Spiecker, D B; Grass, Guido; Schneider, Paul M.; Thiele, Jüergen; Dienes, Hans‐Peter; Hölscher, A. H.

doi:10.1046/j.1365-2559.2001.01306.x

Cited by 89 publications

(62 citation statements)

References 16 publications

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“…Matrix metalloproteinase-2 has been associated with tumor progression, metastasis, and poor prognosis in various different cancers, including those of pancreatic, liver, lung, renal, bladder, gastric, ovarian, and mucosal squamous cell carcinoma origins. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] Matrix metalloproteinase-2 appears to play a role in the degradation of extracellular matrix components, including type IV collagen. [1][2][3] Compromise of the basement membrane, of which type IV collagen is a key component, is a vital step in invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…4,6 Matrix metalloproteinase-2 overexpression has been correlated with tumor invasiveness and metas-tasis in a wide variety of cancer types, [6][7][8][9][10][11][12][13][14][15] including squamous cell carcinoma arising on mucous membranes. [16][17][18][19] A significant increase in matrix metalloproteinase-2 expression has been observed in invasive and metastatic oral squamous cell carcinoma 6,17,19 and has been associated with a shorter disease-free survival. 4,20 However, correlation between matrix metalloproteinase-2 overexpression and the spread and prognosis of cutaneous squamous cell carcinoma has not been characterized in the literature at present.…”

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confidence: 99%

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Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas

2004

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Matrix metalloproteinases compose a family of enzymes involved in degradation of the extracellular matrix. Tumor cells must penetrate the basement membrane and traverse the extracellular matrix in order to invade surrounding structures and metastasize to distant sites. Gelatinases, particularly gelatinase A (matrix metalloproteinase-2), demonstrate degradative activity against components of the basement membrane and may be involved in the progression of in situ squamous cell carcinoma lesions. Matrix metalloproteinase-2 overexpression has been correlated with tumor invasiveness and metastasis in a wide variety of cancer types, including squamous cell carcinoma arising on mucous membranes. However, correlation between matrix metalloproteinase-2 overexpression and the spread and prognosis of cutaneous squamous cell carcinoma has not been characterized in the literature at present. In this study, we used immunohistochemical techniques to examine the expression of matrix metalloproteinase-2 in 10 actinic keratosis, 15 in situ, 13 invasive, 13 primary (with documented metastatic disease), 11 metastatic, and 8 recurrent squamous cell carcinoma cases. We found that while the average staining intensity (scale 0-3 þ , 3 þ being strongest) of actinic keratosis and in situ lesions was not statistically significant (0.87-1.3 and 0.75-1.4, respectively), the average staining intensity of invasive squamous cell carcinomas (1.6-2.5) was significantly greater than that of actinic keratosis and in situ lesions. Likewise, while the average staining intensity of primary squamous cell carcinomas and metastatic squamous cell carcinomas was not found to be statistically significant (3.1-3.5 and 3.1-3.8, respectively), the average staining intensity of these lesions was significantly higher than that of invasive lesions. We also found that the intensity of matrix metalloproteinase-2 staining correlates with cellular atypia, inflammation, neovascularization, and the invasive tumor front, as well as tumor aggressiveness, and may play a role in the pathogenesis, invasion, and metastasis of cutaneous squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas

2004

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“…The role of MMP-2 and MMP-9 has been confirmed in colorectal cancer (3)(4)(5) and gastric cancer (6)(7)(8). Increased levels of MMP-2 and MMP-9 in patients with colorectal and gastric cancer were detected in serum (9,10), plasma (3,9), and tissue (3,11,12).…”

Section: Introductionmentioning

confidence: 88%

Serum levels of matrix metalloproteinase-2 and -9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers

Emara

Cheung

Grabowski

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Background: Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9, play an important role in tumor invasion and metastasis. This study aimed to determine the serum levels of MMP-2, MMP-9, 130-and 225-kDa gelatinolytic bands and conventional tumor markers, carcinoembryonic antigen (CEA) and cancer antigen (CA) 19-9, in patients with gastrointestinal cancers. The relationship between these parameters and clinicopathological factors was also studied. Methods: Sera from controls (ns19), and patients with colorectal (ns47) and gastric (ns34) cancer were collected prospectively. The gelatinolytic activities of MMP-2, MMP-9, 130-and 225-kDa bands were determined using gelatin zymography. CEA and CA 19-9 were determined using immunoradiometric assay (IRMA). Results: Serum levels of MMP-9, 130-and 225-kDa gelatinolytic bands, CEA, and CA 19-9, but not MMP-2, in colorectal and gastric cancer were significantly higher than that of controls. No significant correlation was found between histological grade or clinical stage and levels of MMP-9, 130-and 225-kDa gelatinolytic bands, which were correlated (rs0.61-0.89, p-0.005). Conclusions: Our findings suggest that zymographic determination of

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“…Moreover, MMP-2 has been shown to be a prognostic factor in different malignancies such as ovarian cancer, gastric carcinoma and stage I non-small cell lung carcinoma [87][88][89]. In the next paragraphs, we will highlight the role of MMPs in cancer progression.…”

Section: The Role Of Mmps In Cancermentioning

confidence: 99%

The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia

Klein

Vellenga

Fraaije

et al. 2004

Critical Reviews in Oncology/Hematology

311

170

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Expression of MMP‐2 is associated with progression and lymph node metastasis of gastric carcinoma

Abstract: Expression of MMP-2 is strongly associated with tumour progression and lymph node metastasis in gastric cancer. Therefore MMP-2 staining may be clinically useful as predictor of tumour progression, especially for lymph node metastasis.

Cited by 89 publications

References 16 publications

Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas

Metalloproteinase-2 expression correlates with aggressiveness of cutaneous squamous cell carcinomas

Serum levels of matrix metalloproteinase-2 and -9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers

The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia

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