Expression of MMP-8 and MMP-13 in the development of periradicular lesions

Abstract

These findings indicate that MMP-8 and MMP-13 were related to the development of periradicular lesions. It is suggested that MMP-13 increased from an early stage during their development and that MMP-8 is involved in the progression of tissue destruction including bone resorption.

Expression of Interleukin-1β and Matrix Metalloproteinase-8 in Cytolytic and Noncytolytic Enterococcus faecalis–induced Persistent Apical Periodontitis: A Comparative Study in the Rat

“…The results of our study showed a continuous increase in MMP-8 expression after E. faecalis inoculation. This finding is consistent with the observation by Matsui et al (20). Their research revealed that MMP-8 gene expression increased gradually from 2 to 4 weeks followed by a slight decrease at 6 weeks in experimentally induced AP.…”

“…However, in our study, until the end of the observation period (6 weeks), no decrease in MMP-8 expression was observed. Because MMP-8 is involved in the progression of tissue destruction including bone resorption (20), it is likely that E. faecalis-infected persistent AP may cause more severe periradicular tissue degradation compared with commensal bacteriainfected primary AP.…”

“…Matrix metalloproteinase-8 (MMP-8) is expressed in both humans and rats and belongs to 1 of the subgroups of matrix metalloproteinases (MMPs), namely, collagenases, which are capable of degrading native type I, II, and III fibrillar collagens (18). Previous studies have shown that MMP-8 is closely related to the inflammation and development of periradicular lesions, implying the involvement of MMP-8 in tissue extracellular matrix degradation including bone resorption (19,20). Furthermore, IL-1b and MMP-8 are predominantly secreted by macrophages (21) and pleomorphic nuclear neutrophils (PMNs), respectively (22), which are both primary target cells of Cyl (23).…”

Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone

“…MMP-9 is expressed in giant cell tumor of bone and because normal cells such as fibroblasts do not synthesize MMP-9, the production of MMP-9 may be important for the migration of cells into the blood stream, lymphatic vessels or adjacent normal tissues 74. MMP-13 has been reported to accelerate bone remodeling and promotes proliferation while inhibiting apoptosis in human osteoblast-like cells, and its expression is upregulated in giant cell tumor of bone 75-77. Our study observed, for the first time, the overexpression of the MMP14 gene in multinucleated giant cells, stromal cells and monocytic cells of GCTB.…”

Collagenase-3 expression in periapical lesions: an immunohistochemical study

“…Some cytokines have been described as participating in the pathogenesis, but collagenase-3, which has been detected recently in periapical lesions, seems to play a major role in bone resorption (Khasigov et al 2001). It also has been suggested, however, that in rat periradicular lesions, collagenase-3 increased from an early stage during their development and that MMP-8 also was involved in tissue destruction including bone resorption (Matsui et al 2011).…”