Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia

Yıldırım, Nesligül; Tekin, İshak Özel; Dogan, Sait Mesut; Aydın, Mustafa; Gürsürer, Metin; Cam, Fatih; Gungorduk, Alper; Akoz, Ayla

doi:10.1097/mca.0b013e32801104d4

Cited by 18 publications

(18 citation statements)

References 19 publications

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“…Compared to patients with CAD, higher levels of Creactive protein (CRP) (9), adhesion molecules (27,28), leukocytes (29), metalloproteinase-3 (MMP-3) (30), plasminogen activator inhibitor-1 (31) and phospholipase A2 (32) have been reported in patients with CAE. Studies using epicardial fat, obtained during coronary artery bypass surgery, revealed a significantly higher expression of interleukin-1, interleukin-6, and tumor necrosis factor in epicardial fat than those in leg subcutaneous adipose tissue (16,33).…”

Section: Discussionmentioning

confidence: 99%

Increased Epicardial Adipose Tissue in Patients with Isolated Coronary Artery Ectasia

Çetin¹,

Kocaman²,

Çanğa³

et al. 2012

Intern. Med.

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Background Epicardial adipose tissue (EAT), localized beneath the visceral pericardium, is a metabolically active endocrine and paracrine organ with possible interactions within the heart. Coronary artery ectasia (CAE) is a clinical entity characterized with localized or diffuse dilatation, of the coronary arteries, with a diameter of greater than 1.5 times that of adjacent segments. Although the etiopathogenesis is not clearly understood, some studies have revealed that CAE may be a form of atherosclerosis that has greater inflammatory properties than atherosclerosis. The goal of this study was to investigate whether EAT and the level of C-reactive protein (CRP) are increased in patients with isolated CAE compared to normal subjects. Methods Thirty-three patients with isolated CAE (mean age: 57±9 years) and 32 age-and gender-matched control participants with NCA, but without CAE (mean age: 56±10 years), were included in the study. The relationship between EAT thickness, CRP levels and the presence of CAE was investigated. Results Epicardial adipose tissue thickness was significantly higher in CAE group compared to NCA group (7.2±3.2 vs. 4.7±2.1 mm, p<0.001). Body mass index (BMI, p=0.013), CRP (p=0.047), and the percentage of isolated CAE (p=0.012) were significantly higher in patients with an increased EAT thickness. While CRP correlated with increased EAT, it was not related to CAE. However, CRP levels were higher in patients with diffuse coronary ectatic involvement than the focal lesions (0.58±0.32 vs. 0.31±0.11 mg/dL, p=0.046). When we performed multiple logistic regression analysis, only increased EAT thickness was related to CAE independent of CRP and BMI (OR: 1.442, 95%CI: 1.066-1.951, p=0.018). Conclusion This is the first study, displaying a significantly higher EAT-thickness in patients with isolated CAE. We believe that further studies are needed to clarify the role of adipose tissue in patients with isolated CAE.

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Section: Discussionmentioning

confidence: 99%

Increased Epicardial Adipose Tissue in Patients with Isolated Coronary Artery Ectasia

Çetin¹,

Kocaman²,

Çanğa³

et al. 2012

Intern. Med.

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“…Recent studies showed that the expressions of cellular adhesion molecules including monocytes in patients with CAE are higher than controls [24, 25]. …”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Blood Monocyte Count and Coronary Artery Ectasia

Demir

Keçeoğlu

2014

Cardiol Res

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BackgroundThe pathophysiology of coronary artery ectasia (CAE) has not been clearly identified, although multiple abnormalities including arteritis, endothelial dysfunction, and atherothrombosis have been reported. It is known that monocytes play an important role in inflammation, atherosclerosis and cardiovascular disease. We aimed to compare the numbers of monocyte counts of the CAE patients versus controls.MethodThis study included 84 CAE patients (40 male, mean age 55.4 ± 9.7 years) and 30 controls (10 male, mean age 57.86 ± 11.6 years). Concurrent routine biochemical tests and neutrophil, lymphocyte, monocyte count and mean platelet volume (MPV) on whole blood count were performed for these participants. These parameters were compared between groups.ResultsBaseline characteristics of the study groups were comparable. CAE patients had a higher MPV value and monocyte count than controls (8.8 ± 0.2 vs. 6.2 ± 1.6 fL and 732 ± 88 vs. 321 ± 75 cell/μL; both P < 0.001, respectively).ConclusionAs a result, our study revealed a relationship between monocyte count and MPV in patients with CAE.

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“…57 Elevated cellular adhesion molecule levels in CAE patients may be an indicator of endothelial activation and inflammatory processes. 27 The neutrophil-lymphocyte ratio was significantly higher in the CAE group compared with control, and this ratio was also positively correlated with the number of ectatic segments. 58,59 Furthermore, CAE patients had higher mean platelet and eosinophil volumes.…”

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confidence: 87%

“…). Additionally, there were 5 articles that studied expression of activation markers in peripheral blood 13,26,27 and expression of ACE genotypes. 28,29 Where methods used to test for plasma biomarkers were reported, enzyme-linked immunosorbent assay was used in 20 groups of patients (71.4%), immunonephelometry in 4 (14.3%), florescence polarization immunoassay (FPIA) in 2 (7.1%) and particle enhanced turbidimetric assay (for hsCRP) and sequential immunometric assay (for IL-6) were each used in 1 (3.6%) patient group (c 2 =59.196, p<0.0001).…”

Section: Methodsmentioning

confidence: 99%

“…The search yielded 22 potentially relevant nonrandomized and retrospective studies published from 2000 to 2013. [6][7][8][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Exclusion criteria described in the articles selected included the following: recent or current myocardial infarction, acute coronary syndromes, left ventricular dysfunction, left ventricular hypertrophy, cardiomyopathies, congenital heart disease, valvular heart disease, inflammatory arrhythmias or immunologic diseases, active infection, hepatic, renal or thyroid functional abnormalities, immunosuppressive therapy and statin use.…”

Section: Methodsmentioning

confidence: 99%

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Inflammatory mediators of coronary artery ectasia

Yuan

2014

J. vasc. bras.

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The exact mechanisms underlying coronary artery ectasia (CAE) remain uncertain. This study aims to investigate whether and how inflammatory mediators play a role in the pathogenesis of CAE. The data sources of this study were located by literature searches on MEDLINE, Highwire Press and Google search engine for the year range 2000-2013. The most sensitive of the four types of plasma inflammatory mediators were cell adhesion molecules and systemic inflammatory markers followed by cytokines, while proteolytic substances were the least sensitive indicators of CAE. Hypersensitive C-reaction protein, homocysteine, intercellular adhesion molecule 1, vascular cell adhesion molecule 1, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-2, vascular endothelial growth factor and neopterin levels were significantly higher in CAE and coronary artery disease (CAD) patients than in controls without CAE. The percentage of granulocytes was higher in CAE, in comparison with individuals with normal coronary arteries. Polymerase chain reaction determination of angiotensin converting enzyme genotypes showed that the DD genotype was more prevalent in CAE patients than in CAD patients, while prevalence of the I allele was higher in CAD than in CAE patients. CAE is more a result of inflammatory processes than of extracellular matrix degradation, as demonstrated by investigations of plasma inflammatory mediators, activation markers and angiotensin converting enzyme genotypes. Contemporary theories are unable to explain CAE' s predilection for the right coronary artery or the occurrence of multi-vessel and multi-segment involvement.Keywords: coronary aneurysm; extracellular matrix; inflammation mediators. ResumoOs mecanismos exatos da ectasia de artérias coronárias (EAC) não são completamente compreendidos. Este estudo busca verificar, em detalhes, se e como os mediadores inflamatórios funcionam na pathogenesis de EAC. A fonte de dados do presente estudo veio da recuperação de literatura das investigações relevantes em MEDLINE, na Prensa de Highwire e na ativação de pesquisa do Google, do ano 2000 para 2013. Dos quatro tipos de mediadores inflamatórios do plasma, as moléculas de adesão de célula e os marcadores inflamatórios sistêmicos foram os mais sensíveis, sendo que cytokines foram mais sensíveis e substâncias de protease foram menos sensíveis na indicação da presença de EAC. A proteína C reativa hipersensível, o homocysteine, a molécula de adesão intercelular 1, a molécula de adesão de célula vascular 1, a matriz metalloproteinase-9, o nervo inibidor de tecido de metalloproteinase-2, o fator de crescimento endothelial vascular e os níveis de neopterin foram mais altos nos pacientes com EAC do que nos controles sem EAC. A porcentagem de granulocytes foi mais alta no grupo EAC, comparando-se com os indivíduos com a artéria coronária normal. A determinação de genótipo de enzima do angiotensin-conversão utilizando-se a técnica de reação em cadeia da polimerase revelou que o genótipo DD foi prevalecente na EAC, ma...

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Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia

Abstract: Increased levels of cellular adhesion molecules in patients with coronary artery ectasia may be an indicator of endothelial activation and inflammation and are likely to be in the causal pathway leading to coronary artery ectasia.

Cited by 18 publications

References 19 publications

Increased Epicardial Adipose Tissue in Patients with Isolated Coronary Artery Ectasia

Increased Epicardial Adipose Tissue in Patients with Isolated Coronary Artery Ectasia

The Relationship Between Blood Monocyte Count and Coronary Artery Ectasia

Inflammatory mediators of coronary artery ectasia

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