Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours

Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion

“…Our own studies have demonstrated an increased expression in cancers of the ovary, breast, colon, stomach, lung, and bladder (McGuckin et al, 1990(McGuckin et al, , 1991(McGuckin et al, , 1995bWalsh et al, 1994;Dong et al, 1997). This increase in expression has been shown to be caused by a gene dosage effect in some tumours, but more often by an increase in MUC1 transcription (Bieche and Lidereau, 1997).…”

“…This increase in expression has been shown to be caused by a gene dosage effect in some tumours, but more often by an increase in MUC1 transcription (Bieche and Lidereau, 1997). A high cytoplasmic expression of MUC1 has been associated with poorer prognosis in breast and ovarian cancers (McGuckin et al, 1995b;Dong et al, 1997), although a mechanism by which MUC1 itself contributes to tumour aggressiveness has not been clearly demonstrated.…”

The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas

“…High levels of cytoplasmic MUC1 have been reported to be associated with more aggressive tumor phenotype and have prognostic significance in a variety of tumor types including breast [30], ovarian [31], and colorectal cancers [32]. Because high cytoplasmic expression of MUC13 was seen in colorectal cancers, we sought to investigate the relationship between both the extent and intensity of cytoplasmic MUC13 staining and clinicopathological parameters (Table 4).…”

Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

“…However, malignant transformation usually alters this. [131][132][133][134][135][136][137][138][139][140][141][142][143][144][145][146] Alterations in expression of mucin carbohydrate or peptide antigens or both are progressively described in carcinomas developed from various tissues such as breast, [147,148] endometrium, [149] ovary, [150,151] pharynx and larynx, [152] lung, [153] stomach, [154,155] liver, [156] gall bladder, [157,158] pancreas, [159,160] and small and large intestine. [161][162][163] Some mucins are rarely expressed in normal tissues, but are anomalously expressed in tumoural tissues.…”