Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance

Zhang, Hongkai; Zhang, Qiumin; Zhao, Tong; Li, Yuanyuan; Yi, Yongxiang

doi:10.3748/wjg.v10.i20.3044

Cited by 41 publications

(43 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Their functions are to form a mucous gel covering the surfaces of epithelial tissues in order to lubricate and protect them (1)(2)(3)(4)(5)(6)(7)(8). Their genes are clustered on chromosome 11p15.5 (4).…”

Section: Introductionmentioning

confidence: 99%

“…MUC2 is the main mucin of the intestinal mucosa and respiratory system, and does not show any staining in normal gastric epithelium; however, de novo expressions appear in the areas of intestinal metaplasia (IM) and in malignancies (1)(2)(3)(4)(5)(6)(7)(8)(13)(14)(15)(16)(17)(18)(19)(20). The expression of MUC2 is very common in mucinous carcinomas of different organs such as breast, colon and prostate (21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

“…MUC5AC, a gastric-type mucin of the cardia and corpus of the stomach, is widely expressed in normal gastric epithelium (3,4,(6)(7)(8)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

“…These changes, playing a great role in cellular growth and adhesion and also in immune system regulation, affect the invasion and metastatic capacity of the tumor. In many studies, decreases in the expression rates of MUC1 and MUC5AC and de novo MUC2 expression in gastric carcinomas have been shown to be correlated with the prognosis (1)(2)(3)(4)(5)(6)(7)(8)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma

İlhan

Han²,

Önal³

et al. 2010

Turk J Gastroenterol

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…MUC5AC, a gastric-type mucin of the cardia and corpus of the stomach, is widely expressed in normal gastric epithelium (3,4,(6)(7)(8)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma

İlhan

Han²,

Önal³

et al. 2010

Turk J Gastroenterol

View full text Add to dashboard Cite

“…Reduction/loss of E-cadherin has been associated with the development and progression of human carcinomas, by contributing to tumour invasion and metastases (Charalabopoulos et al, 2002;Hirohashi and Kanai, 2003). Abnormal E-cadherin expression (heterogeneous, cytoplasmic, or absent) has been detected immunohistochemically in a variety of poorly differentiated, invasive and metastatic carcinomas, such as gastric adenocarcinoma, lobular breast carcinoma, colorectal tumours, prostate adenocarcinoma, pancreatic, and bladder cancer (Charalabopoulos et al, 2002(Charalabopoulos et al, , 2004Chang et al, 2002;Hirohashi and Kanai, 2003;Zhang et al, 2004;Massarelli et al, 2005). Regarding testicular neoplasms, there are less than a handful of studies, with conflicting results (Heidenreich et al, 1998;Saito et al, 2000;Honecker et al, 2004).…”

mentioning

confidence: 99%

Involvement of dysadherin and E-cadherin in the development of testicular tumours

et al. 2005

View full text Add to dashboard Cite

Testicular neoplasms are comprised of a variety of histologically different forms, and their pathogenesis has not been elucidated. Dysadherin is a recently described cell membrane glycoprotein, which has an anticell -cell adhesion function and downregulates E-cadherin. In this study, we examined immunohistochemically the expression of E-cadherin and dysadherin in 120 testicular neoplasms (37 seminomas-26 classic, five spermatocytic and six anaplastic-, 45 embryonal carcinomas, 10 mixed germ cell tumours, two yolk sac tumours, 10 mature and eight immature teratomas and eight non-Hodgkin B-cell lymphomas), clinical stage I. The intensity, the expression pattern and the percentage of neoplastic cell staining was recorded and correlated with the histologic type and vascular/lymphatic invasion. Dysadherin was not expressed in non-neoplastic germ cells, neither in CIS/ITGCNU, but it was highly expressed in all types of germ cell tumours, that demonstrated either embryonic phenotype or somatic differentiation, in most terminally differentiated neoplasms, and in all lymphomas. Dysadherin expression did not correlate with vascular invasion. Increased dysadherin expression was correlated with aberrant E-cadherin expression in most tumours. In 17% of embryonal carcinomas colocalisation of dysadherin and membranous E-cadherin staining was noted. This is the first report on dysadherin expression and its association with E-cadherin in testicular tumours. Since dysadherin is not normally expressed in non-neoplastic testis, it is conceivable that it plays a role in the neoplastic transformation of germ cells. In testicular tumours, as in other neoplasms, dysadherin downregulates E-cadherin expression, at least in part.

show abstract

MT1‐MMP and TIMP‐2 are first expressed in the colon glands after a single dose of azoxymethane (AOM)

da Silva,

Freitas,

do Carmo

et al. 2023

The Anatomical Record

View full text Add to dashboard Cite

Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) and membrane‐type 1‐matrix metalloproteinase (MT1‐MMP) are always expressed during the cancer process. The aim was to identify which regions of the colon mucosa MT1‐MMP and TIMP‐2 begin to express themselves, as well as to establish their expression in relation to cell proliferation and mucin production. After intraperitoneal injection of 15 mg/kg of azoxymethane (AOM) at 4, 12, and 20 weeks, histological sections of the middle segment of the rat colon mucosa were evaluated by immunohistochemistry for cell proliferation and expression of MT1‐MMP and TIMP‐2 and histochemistry for mucin. As a result, a single dose of AOM initially increased the intensity of MT1‐MMP and TIMP‐2 expression in the conjunctive cells and glands, concurrently with alterations in the distribution of the mucin produced in the gland of the large intestine mucosa and cell proliferation. As a result, at 4 and 12 weeks, a single dose of AOM initially stimulated the expression of MT1‐MMP and TIMP‐2 in the conjunctive cells and glands with greater intensity. Changes in the cell proliferation and distribution of the mucin produced in the large intestine mucosa gland were observed. We conclude that MT1‐MMP and TIMP‐2 were first and strongly expressed in all cells of the colon glands, concurrently with an increase in cell proliferation and a diffuse dispersion of mucin, indicating the onset of the dysplasia process following a single dosage of AOM.

show abstract

Expression of mucins and E-cadherin in gastric carcinoma and their clinical significance

Cited by 41 publications

References 22 publications

Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma

Prognostic significance of MUC1, MUC2 and MUC5AC expressions in gastric carcinoma

Involvement of dysadherin and E-cadherin in the development of testicular tumours

MT1‐MMP and TIMP‐2 are first expressed in the colon glands after a single dose of azoxymethane (AOM)

Contact Info

Product

Resources

About